World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
61
Citations
18686
World Ranking
11155
National Ranking
4828

Overview

Jen-Tsan Chi is affiliated with Duke University in the United States and has contributed extensively to the fields of biochemistry, genetics, and molecular biology, with a particular focus within medicine. Their research portfolio includes a broad exploration of molecular mechanisms underlying disease processes, with notable emphasis on cancer, ferroptosis, and metabolic regulation.

Chi's recent published papers demonstrate a consistent focus on ferroptosis, a regulated form of cell death linked to cancer and metabolic diseases. These works include:

  • "A guideline on the molecular ecosystem regulating ferroptosis" (2024) published in Nature Cell Biology
  • "MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis" (2020) published in Nature Metabolism
  • "The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling" (2021) published in Nature Communications
  • "International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis" (2024) published in Autophagy
  • "Zinc transporter ZIP7 is a novel determinant of ferroptosis" (2021) published in Cell Death and Disease

Their frequent coauthors include Chao-Chieh Lin, Jianli Wu, Stephen J. Freedland, Po-Han Chen, and Yasaman Setayeshpour, reflecting a collaborative research approach.

Jen-Tsan Chi publishes regularly in a number of scientific venues, with multiple publications appearing in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Death and Disease
  • UNC Libraries
  • Cancers
  • Nature Communications

Their main fields of study are biochemistry, genetics, and molecular biology along with medicine. Subfields of interest include molecular biology, pulmonary and respiratory medicine, cancer research, cell biology, and physiology.

Chi's primary research topics cover:

  • Ferroptosis and cancer prognosis
  • RNA modifications and cancer
  • Epigenetics and DNA methylation
  • Hippo pathway signaling and YAP/TAZ
  • Diet and metabolism studies
  • Cancer, hypoxia, and metabolism
  • Autophagy in disease and therapy

Best Publications

  • Retraction Note: Lysyl oxidase is essential for hypoxia-induced metastasis

    Janine T. Erler;Kevin L. Bennewith;Monica Nicolau;Nadja Dornhöfer

  • Diversity, topographic differentiation, and positional memory in human fibroblasts

    Howard Y. Chang;Jen-Tsan Chi;Sandrine Dudoit;Chanda Bondre

  • Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities between Tumors and Wounds

    Howard Y. Chang;Julie B Sneddon;Ash A. Alizadeh;Ruchira Sood

  • Endothelial cell diversity revealed by global expression profiling

    Jen-Tsan Chi;Howard Y. Chang;Guttorm Haraldsen;Frode L. Jahnsen

  • Gene Expression Programs in Response to Hypoxia: Cell Type Specificity and Prognostic Significance in Human Cancers

    Jen Tsan Chi;Jen Tsan Chi;Zhen Wang;Dimitry S.A. Nuyten;Edwin H. Rodriguez

  • A viral microRNA functions as an orthologue of cellular miR-155

    Eva Gottwein;Neelanjan Mukherjee;Christoph Sachse;Corina Frenzel

  • Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality

    Denise A. Chan;Patrick D. Sutphin;Phuong Nguyen;Sandra Turcotte

  • Systemic and cell type-specific gene expression patterns in scleroderma skin.

    Michael L. Whitfield;Deborah R. Finlay;John Isaac Murray;Olga G. Troyanskaya

  • Genomewide view of gene silencing by small interfering RNAs

    Jen-Tsan Chi;Howard Y. Chang;Nancy N. Wang;Dustin S. Chang

  • microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease.

    Carolyn Sangokoya;Marilyn J. Telen;Jen-Tsan Chi

  • The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma.

    Wen-Hsuan Yang;Chien-Kuang Cornelia Ding;Tianai Sun;Gabrielle Rupprecht

  • Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells

    Heather A Himburg;Garrett G Muramoto;Pamela Daher;Sarah K Meadows

  • Translocation of Sickle Cell Erythrocyte MicroRNAs into Plasmodium falciparum Inhibits Parasite Translation and Contributes to Malaria Resistance

    Gregory LaMonte;Nisha Philip;Joseph Reardon;Joshua R. Lacsina

  • Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia.

    Hsiu-Ni Kung;Jeffrey R. Marks;Jen-Tsan Chi

  • Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment.

    Denise A. Chan;Tiara L A Kawahara;Patrick D. Sutphin;Howard Y. Chang

  • The genomic analysis of lactic acidosis and acidosis response in human cancers.

    Julia Ling-Yu Chen;Joseph E. Lucas;Thies Schroeder;Seiichi Mori

  • The genomic analysis of erythrocyte microRNA expression in sickle cell diseases.

    Shao-Yin Chen;Yulei Wang;Marilyn J. Telen;Jen-Tsan Chi

  • A TAZ-ANGPTL4-NOX2 Axis Regulates Ferroptotic Cell Death and Chemoresistance in Epithelial Ovarian Cancer

    Wen-Hsuan Yang;Zhiqing Huang;Jianli Wu;Chien-Kuang C. Ding

  • Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism

    Po-Han Chen;Jianli Wu;Chien-Kuang Cornelia Ding;Chao-Chieh Lin

  • A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation

    Christopher G Duncan;Benjamin G Barwick;Genglin Jin;Carlo Rago

Frequent Co-Authors

Stephen J. Freedland
Stephen J. Freedland Cedars-Sinai Medical Center
Mark W. Dewhirst
Mark W. Dewhirst Duke University
Patrick O. Brown
Patrick O. Brown Stanford University
Amato J. Giaccia
Amato J. Giaccia Stanford University
Howard Y. Chang
Howard Y. Chang Amgen (United States)
Thomas L. Ortel
Thomas L. Ortel Duke University
Jeffrey R. Marks
Jeffrey R. Marks Duke University
Tso-Pang Yao
Tso-Pang Yao Duke University
Geoffrey S. Ginsburg
Geoffrey S. Ginsburg Duke University
Mike West
Mike West Duke University

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