World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
65
Citations
39721
World Ranking
1638
National Ranking
828

Overview

Anastasia Khvorova is affiliated with the University of Massachusetts Chan Medical School in the United States. Their research primarily falls within the domain of Biochemistry, Genetics and Molecular Biology, with a significant focus on Molecular Biology, Cellular and Molecular Neuroscience, Cancer Research, Genetics, and Immunology.

The scientist's work covers a range of main topics including RNA Interference and Gene Delivery, Advanced biosensing and bioanalysis techniques, MicroRNA in disease regulation, Genetic Neurodegenerative Diseases, RNA Research and Splicing, CRISPR and Genetic Engineering, and Muscle Physiology and Disorders.

Khvorova has published extensively, with frequent contributions appearing in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nucleic Acids Research, Molecular Therapy - Nucleic Acids, Molecular Therapy, and Nucleic Acid Therapeutics.

Some of their recent papers include:

  • RNAi-based drug design: considerations and future directions (2024, Nature Reviews Drug Discovery)
  • The NIH Somatic Cell Genome Editing program (2021, Nature)
  • The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy (2020, Nucleic Acids Research)
  • AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma (2021, The Journal of Experimental Medicine)
  • Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles (2020, Molecular Therapy)

Khvorova frequently collaborates with several co-authors, including Dimas Echeverria, Nicholas McHugh, Neil Aronin, Julia F. Alterman, and Ken Yamada, with collaborative counts ranging from 19 to 43 joint publications.

Best Publications

  • Minimal information for studies of extracellular vesicles 2018 (MISEV2018) : a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

    Clotilde Théry;Kenneth W. Witwer;Elena Aikawa;Maria Jose Alcaraz

  • Functional siRNAs and miRNAs Exhibit Strand Bias

    Anastasia Khvorova;Angela Reynolds;Angela Reynolds;Sumedha D. Jayasena

  • Rational siRNA design for RNA interference

    Angela Reynolds;Devin Leake;Queta Boese;Stephen Scaringe

  • FUNCTIONAL siRNA, AND SUPER FUNCTIONAL siRNA

    Khvorova Anastasia;Reynolds Angela;Leake Devin;Marshall William

  • 3' UTR SEED MATCHES, BUT NOT OVERALL IDENTITY, ARE ASSOCIATED WITH RNAI OFF-TARGETS

    Amanda Birmingham;Emily M Anderson;Angela Reynolds;Diane Ilsley-Tyree

  • Position-specific chemical modification of siRNAs reduces “off-target” transcript silencing

    Aimee L. Jackson;Julja Burchard;Devin Leake;Angela Reynolds

  • The chemical evolution of oligonucleotide therapies of clinical utility.

    Anastasia Khvorova;Jonathan K Watts

  • Identification of the gene for vitamin K epoxide reductase

    Tao Li;Chun Yun Chang;Da Yun Jin;Pen Jen Lin

  • High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources.

    Reka A. Haraszti;Marie-Cecile Didiot;Ellen Sapp;John D. Leszyk

  • Off-target effects by siRNA can induce toxic phenotype.

    Yuriy Fedorov;Emily M. Anderson;Amanda Birmingham;Angela Reynolds

  • Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference

    Fangtian Huang;Anastasia Khvorova;William Marshall;Alexander Sorkin

  • Sequence elements outside the hammerhead ribozyme catalytic core enable intracellular activity.

    Anastasia Khvorova;Aurélie Lescoute;Eric Westhof;Sumedha D Jayasena

  • Exosomes Produced from 3D Cultures of MSCs by Tangential Flow Filtration Show Higher Yield and Improved Activity

    Reka Agnes Haraszti;Rachael Miller;Matteo Stoppato;Yves Y. Sere

  • Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing

    Marie-Cécile Didiot;Lauren M Hall;Andrew H Coles;Reka A Haraszti

  • Identification of genes that regulate epithelial cell migration using an siRNA screening approach.

    Kaylene J. Simpson;Laura M. Selfors;James Bui;Angela Reynolds

  • RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells

    Joyce A. Wilson;Sumedha Jayasena;Anastasia Khvorova;Sarah Sabatinos

  • Methods and compositions for selecting siRNA of improved functionality

    Anastasia Khvorova;Angela Reynolds;Devin Leake;William Marshall

  • Induction of the interferon response by siRNA is cell type- and duplex length-dependent.

    Angela Reynolds;Emily M. Anderson;Annaleen Vermeulen;Yuriy Fedorov

  • The contributions of dsRNA structure to Dicer specificity and efficiency.

    Annaleen Vermeulen;Linda Behlen;Angela Reynolds;Alexey Wolfson

  • A library of siRNA duplexes targeting the phosphoinositide 3‐kinase pathway: determinants of gene silencing for use in cell‐based screens

    Andrew C. Hsieh;Ronghai Bo;Judith Manola;Francisca Vazquez

Frequent Co-Authors

Neil Aronin
Neil Aronin University of Massachusetts Chan Medical School
Marian DiFiglia
Marian DiFiglia Harvard University
Juan Sanchez-Ramos
Juan Sanchez-Ramos University of South Florida
Paul S. Miller
Paul S. Miller Johns Hopkins University
S. Ananth Karumanchi
S. Ananth Karumanchi Cedars-Sinai Medical Center
Michael Yarus
Michael Yarus University of Colorado Boulder
Melissa J. Moore
Melissa J. Moore University of Massachusetts Chan Medical School
Eric Westhof
Eric Westhof University of Strasbourg
David R. Liu
David R. Liu Broad Institute
Erik J. Sontheimer
Erik J. Sontheimer University of Massachusetts Chan Medical School

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Pursuing a degree in Molecular Biology opens doors to many interdisciplinary and healthcare career pathways. For students considering a shift into healthcare, various online programs now offer flexible, accelerated tracks. For instance, those interested in communication sciences can explore slp bridge programs, designed to help non-SLP majors transition smoothly into Speech-Language Pathology graduate studies.

Another popular route is nursing. Individuals without a nursing background can fast-track their careers through online bsn programs for non nurses. These programs allow graduates of diverse fields—including Molecular Biology—to pivot into nursing and gain essential clinical skills.

As you plan your transition, understanding earning potential and licensure requirements is crucial. For example, Psychiatric-Mental Health Nurse Practitioners (PMHNPs) remain in high demand, with compensation that varies across the country; you can explore pmhnp salary by state. Wondering about the fastest path to a rewarding healthcare role? Discover how to become nurse practitioner in the shortest time possible.

Best Scientists Citing Anastasia Khvorova

Trending Scientists

Recently Published Articles