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Biology and Biochemistry

D-Index
71
Citations
19783
World Ranking
6584
National Ranking
3067

Overview

Alexander Sorkin is affiliated with the University of Pittsburgh in the United States and has a research focus spanning biochemistry, genetics, molecular biology, and medicine. Their research contributions primarily lie within molecular biology, cell biology, cellular and molecular neuroscience, obstetrics and gynecology, and radiology, nuclear medicine, and imaging. The scientist's work often intersects with topics related to receptor mechanisms and signaling, cellular transport and secretion, monoclonal and polyclonal antibodies research, neurotransmitter receptor influence on behavior, pregnancy and preeclampsia studies, reproductive system and pregnancy, and neuroscience and neuropharmacology research.

Sorkin's recent publications reflect a focus on cellular signaling pathways and placental biology. Notable papers include:

  • Mechanisms for Regulating and Organizing Receptor Signaling by Endocytosis, 2021, Annual Review of Biochemistry
  • Term Human Placental Trophoblasts Express SARS-CoV-2 Entry Factors ACE2, TMPRSS2, and Furin, 2021, mSphere
  • Placental response to maternal SARS-CoV-2 infection, 2021, Scientific Reports
  • Placental small extracellular vesicles: Current questions and investigative opportunities, 2020, Placenta
  • Endocytosis: A Turnover Mechanism Controlling Ion Channel Function, 2020, Cells

Their frequent co-authors include:

  • Yingshi Ouyang
  • Tarique Rajasaheb Bagalkot
  • Yoel Sadovsky
  • Simon C. Watkins
  • Elena Sadovsky

Sorkin's research is frequently published in venues such as bioRxiv (Cold Spring Harbor Laboratory), Cell Reports, The Journal of Cell Biology, Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature, and Annual Review of Biochemistry.

The scientist contributes extensively to understanding receptor signaling mechanisms and the cellular processes governing molecular transport and secretion. Their work on placental biology has addressed critical questions about the expression of viral entry factors in placental cells and vesicle-mediated communication relevant to pregnancy and maternal-fetal interactions.

Best Publications

  • Endocytosis and signalling: intertwining molecular networks

    Alexander Sorkin;Mark von Zastrow

  • Endocytosis and intracellular trafficking of ErbBs.

    Alexander Sorkin;Lai Kuan Goh

  • Signal transduction and endocytosis: close encounters of many kinds.

    Alexander Sorkin;Mark von Zastrow

  • Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain.

    Fangtian Huang;Donald Kirkpatrick;Xuejun Jiang;Steven Gygi

  • Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference

    Fangtian Huang;Anastasia Khvorova;William Marshall;Alexander Sorkin

  • Endocytosis of Receptor Tyrosine Kinases

    Lai Kuan Goh;Alexander Sorkin

  • Clathrin Assembly Lymphoid Myeloid Leukemia (CALM) Protein: Localization in Endocytic-coated Pits, Interactions with Clathrin, and the Impact of Overexpression on Clathrin-mediated Traffic

    Francesc Tebar;Stefan K. Bohlander;Alexander Sorkin

  • Interaction of EGF receptor and Grb2 in living cells visualized by fluorescence resonance energy transfer (FRET) microscopy

    Alexander Sorkin;Maria McClure;Fangtian Huang;Royston Carter

  • Grb2 Regulates Internalization of EGF Receptors through Clathrin-coated Pits

    Xuejun Jiang;Fangtian Huang;Andriy Marusyk;Alexander Sorkin

  • Endocytosis of growth factor receptors

    Alexander Sorkin;Christopher M. Waters

  • Signaling on the endocytic pathway.

    Mark von Zastrow;Alexander Sorkin

  • Eps15 Is a Component of Clathrin-coated Pits and Vesicles and Is Located at the Rim of Coated Pits

    Francesc Tebar;Tatiana Sorkina;Alexander Sorkin;Maria Ericsson

  • Interaction of activated EGF receptors with coated pit adaptins.

    Alexander Sorkin;Graham Carpenter

  • Endocytosis of Functional Epidermal Growth Factor Receptor-Green Fluorescent Protein Chimera

    Royston E. Carter;Alexander Sorkin

  • Inhibition of the receptor‐binding function of clathrin adaptor protein AP‐2 by dominant‐negative mutant μ2 subunit and its effects on endocytosis

    Alexandre Nesterov;Royston E. Carter;Tatiana Sorkina;Gordon N. Gill

  • Cargo recognition during clathrin-mediated endocytosis: a team effort

    Alexander Sorkin

  • Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptor

    Lai Kuan Goh;Fangtian Huang;Woong Kim;Steven P. Gygi

  • Oligomerization of Dopamine Transporters Visualized in Living Cells by Fluorescence Resonance Energy Transfer Microscopy

    Tatiana Sorkina;Suzanne Doolen;Emilia Galperin;Nancy R. Zahniser

  • Regulation of receptors and transporters by ubiquitination: new insights into surprisingly similar mechanisms.

    Manuel Miranda;Alexander Sorkin

  • Coordinated Traffic of Grb2 and Ras during Epidermal Growth Factor Receptor Endocytosis Visualized in Living Cells

    Xuejun Jiang;Alexander Sorkin

Frequent Co-Authors

Simon C. Watkins
Simon C. Watkins University of Pittsburgh
Nancy R. Zahniser
Nancy R. Zahniser University of Colorado Denver
Graham Carpenter
Graham Carpenter Vanderbilt University
Ivet Bahar
Ivet Bahar University of Pittsburgh
Yoel Sadovsky
Yoel Sadovsky University of Pittsburgh
Xuejun Jiang
Xuejun Jiang Memorial Sloan Kettering Cancer Center
Steven P. Gygi
Steven P. Gygi Harvard University
Christopher M. Waters
Christopher M. Waters Michigan State University
Pier Paolo Di Fiore
Pier Paolo Di Fiore University of Milan
Mark von Zastrow
Mark von Zastrow University of California, San Francisco

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