Alexander Sorkin spends much of his time researching Cell biology, Endocytosis, Endosome, Endocytic cycle and Clathrin. His work carried out in the field of Cell biology brings together such families of science as Epidermal growth factor and Clathrin adaptor complex. His biological study spans a wide range of topics, including Internalization and Receptor tyrosine kinase, Signal transduction, Signal transducing adaptor protein.
His research in Internalization tackles topics such as Transferrin receptor which are related to areas like Dynamin. His work in Endosome covers topics such as Förster resonance energy transfer which are related to areas like Dopamine transporter, Dopamine Plasma Membrane Transport Proteins, Biophysics, HEK 293 cells and Endoplasmic reticulum. As part of one scientific family, Alexander Sorkin deals mainly with the area of Clathrin, narrowing it down to issues related to the Coated vesicle, and often Immunoelectron microscopy, Budding and Transmembrane protein.
Cell biology, Endocytosis, Endosome, Internalization and Epidermal growth factor are his primary areas of study. His research in Cell biology intersects with topics in Receptor, Biochemistry and Clathrin. His Endocytosis research is multidisciplinary, incorporating elements of Dopamine transporter and Signal transducing adaptor protein.
His Endosome study combines topics in areas such as Transport protein, Protein kinase A, Yellow fluorescent protein, GRB2 and Förster resonance energy transfer. His Internalization research incorporates themes from Molecular biology and Protein kinase C, Phosphorylation, Kinase activity. The various areas that Alexander Sorkin examines in his Epidermal growth factor study include GRB2 Adaptor Protein, Growth factor receptor and ERBB3, Epidermal growth factor receptor.
His primary scientific interests are in Cell biology, Endocytosis, Dopamine transporter, Endocytic cycle and Internalization. His work on Endosome and Intracellular as part of his general Cell biology study is frequently connected to Biogenesis and Microvesicles, thereby bridging the divide between different branches of science. His work in Endosome tackles topics such as Endogeny which are related to areas like Phosphatase, Receptor-mediated endocytosis and High-throughput screening.
His Endocytosis research incorporates elements of Phosphorylation and Receptor signaling. His Dopamine transporter research incorporates themes from Biophysics and Small molecule. The study incorporates disciplines such as Pinocytosis, Clathrin and Transmembrane protein in addition to Endocytic cycle.
His primary areas of investigation include Endocytosis, Dopamine transporter, Biophysics, Cell biology and Endocytic cycle. Alexander Sorkin interconnects Internalization and Cancer research in the investigation of issues within Endocytosis. His studies deal with areas such as Plasma protein binding, Biochemistry, Intracellular and Dopaminergic, Dopamine as well as Biophysics.
His study in Endosome and Protein kinase C is carried out as part of his Cell biology studies. His Endosome research incorporates elements of Dynamin, Pinocytosis and Clathrin. The concepts of his Endocytic cycle study are interwoven with issues in Allosteric regulation, Adenosine and Actin cytoskeleton.
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Endocytosis and signalling: intertwining molecular networks
Alexander Sorkin;Mark von Zastrow.
Nature Reviews Molecular Cell Biology (2009)
Signal transduction and endocytosis: close encounters of many kinds.
Alexander Sorkin;Mark von Zastrow.
Nature Reviews Molecular Cell Biology (2002)
Endocytosis and intracellular trafficking of ErbBs.
Alexander Sorkin;Lai Kuan Goh.
Experimental Cell Research (2009)
Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain.
Fangtian Huang;Donald Kirkpatrick;Xuejun Jiang;Steven Gygi.
Molecular Cell (2006)
Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference.
Fangtian Huang;Anastasia Khvorova;William Marshall;Alexander Sorkin.
Journal of Biological Chemistry (2004)
Interaction of EGF receptor and Grb2 in living cells visualized by fluorescence resonance energy transfer (FRET) microscopy
Alexander Sorkin;Maria McClure;Fangtian Huang;Royston Carter.
Current Biology (2000)
Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic.
Francesc Tebar;Stefan K. Bohlander;Alexander Sorkin.
Molecular Biology of the Cell (1999)
Endocytosis of Receptor Tyrosine Kinases
Lai Kuan Goh;Alexander Sorkin.
Cold Spring Harbor Perspectives in Biology (2013)
Grb2 Regulates Internalization of EGF Receptors through Clathrin-coated Pits
Xuejun Jiang;Fangtian Huang;Andriy Marusyk;Alexander Sorkin.
Molecular Biology of the Cell (2003)
Eps15 Is a Component of Clathrin-coated Pits and Vesicles and Is Located at the Rim of Coated Pits
Francesc Tebar;Tatiana Sorkina;Alexander Sorkin;Maria Ericsson.
Journal of Biological Chemistry (1996)
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