World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
83
Citations
31101
World Ranking
3444
National Ranking
1734

Overview

Neil Aronin is affiliated with the University of Massachusetts Chan Medical School in the United States. Their research primarily focuses on Biochemistry, Genetics, and Molecular Biology, with additional work in Neuroscience. The subfields covered include Molecular Biology, Cellular and Molecular Neuroscience, Genetics, Cancer Research, and Neurology.

Aronin's research topics span several areas with a concentration on Genetic Neurodegenerative Diseases and RNA-related mechanisms. Key themes in their work include:

  • Genetic Neurodegenerative Diseases
  • RNA Interference and Gene Delivery
  • RNA Research and Splicing
  • Advanced biosensing and bioanalysis techniques
  • Mitochondrial Function and Pathology
  • Muscle Physiology and Disorders
  • CRISPR and Genetic Engineering

The scientist's recent publications illustrate a focus on RNA interference techniques and Huntington's disease. Notable papers include:

  • "Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington's disease," 2023, published in Molecular Therapy
  • "Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington's disease models," 2022, published in Nature Communications
  • "Large Animal Models of Huntington's Disease: What We Have Learned and Where We Need to Go Next," 2020, Journal of Huntington's Disease
  • "Enhancing siRNA efficacy in vivo with extended nucleic acid backbones," 2024, Nature Biotechnology
  • "Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep," 2021, JCI Insight

Frequent coauthors include Ellen Sapp, Marian DiFiglia, Anastasia Khvorova, Rachael Miller, and Dimas Echeverria.

The scientist has published extensively in several academic venues, with multiple papers featured in bioRxiv (Cold Spring Harbor Laboratory), Molecular Therapy, Nucleic Acids Research, Journal of Huntington's Disease, and Brain Communications.

Best Publications

  • Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

    Marian DiFiglia;Ellen Sapp;Kathryn O. Chase;Stephen W. Davies

  • Asymmetry in the assembly of the RNAi enzyme complex.

    Dianne S. Schwarz;György Hutvágner;Tingting Du;Zuoshang Xu

  • Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons.

    Marian DiFiglia;Ellen Sapp;Kathryn Chase;Cordula Schwarz

  • Von Hippel–Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma

    B. R. Seizinger;G. A. Rouleau;L. J. Ozelius;A. H. Lane

  • High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources.

    Reka A. Haraszti;Marie-Cecile Didiot;Ellen Sapp;John D. Leszyk

  • Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy.

    Kimberly B. Kegel;Manho Kim;Ellen Sapp;Charmian McIntyre

  • Early and progressive accumulation of reactive microglia in the Huntington disease brain.

    E. Sapp;K. B. Kegel;N. Aronin;T. Hashikawa

  • Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis

    Yun J. Kim;Yong Yi;Ellen Sapp;Yumei Wang

  • Exosomes Produced from 3D Cultures of MSCs by Tangential Flow Filtration Show Higher Yield and Improved Activity

    Reka Agnes Haraszti;Rachael Miller;Matteo Stoppato;Yves Y. Sere

  • Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits

    Marian DiFiglia;Miguel Sena-Esteves;Kathryn O. Chase;Ellen Sapp

  • Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing

    Marie-Cécile Didiot;Lauren M Hall;Andrew H Coles;Reka A Haraszti

  • Environmental iodine intake and thyroid dysfunction during chronic amiodarone therapy

    E Martino;M Safran;F Aghini-Lombardi;R Rajatanavin

  • Germline mutations in TMEM127 confer susceptibility to pheochromocytoma

    Yuejuan Qin;Li Qin Yao;Elizabeth E. King;Kalyan Buddavarapu

  • Huntingtin localization in brains of normal and Huntington's disease patients.

    E. Sapp;C. Schwarz;K. Chase;P. G. Bhide

  • Wild-Type and Mutant Huntingtins Function in Vesicle Trafficking in the Secretory and Endocytic Pathways

    James Velier;Manho Kim;Cordula Schwarz;Tae Wan Kim

  • Light regulates expression of a Fos-related protein in rat suprachiasmatic nuclei.

    Neil Aronin;Stephen M. Sagar;Frank R. Sharp;William J. Schwartz

  • Five siRNAs targeting three SNPs may provide therapy for three-quarters of Huntington's disease patients.

    Edith L. Pfister;Lori A. Kennington;Juerg R. Straubhaar;Sujata Wagh

  • Immunohistochemical localization of the D1 dopamine receptor in rat brain reveals its axonal transport, pre- and postsynaptic localization, and prevalence in the basal ganglia, limbic system, and thalamic reticular nucleus.

    Qin Huang;Dan Zhou;Kathy Chase;James F. Gusella

  • Huntingtin Is Present in the Nucleus, Interacts with the Transcriptional Corepressor C-terminal Binding Protein, and Represses Transcription

    Kimberly B. Kegel;Alison R. Meloni;Yong Yi;Yun J. Kim

  • Designing siRNA that distinguish between genes that differ by a single nucleotide.

    Dianne S. Schwarz;Hongliu Ding;Lori A. Kennington;Jessica T. Moore

Frequent Co-Authors

Marian DiFiglia
Marian DiFiglia Harvard University
Anastasia Khvorova
Anastasia Khvorova University of Massachusetts Chan Medical School
Miguel Sena-Esteves
Miguel Sena-Esteves University of Massachusetts Chan Medical School
Phillip D. Zamore
Phillip D. Zamore University of Massachusetts Chan Medical School
Susan E. Leeman
Susan E. Leeman Boston University
William J. Schwartz
William J. Schwartz The University of Texas at Austin
Manho Kim
Manho Kim Seoul National University Hospital
Christian Mueller
Christian Mueller University of Massachusetts Chan Medical School
Anne B. Young
Anne B. Young Harvard University
Guangping Gao
Guangping Gao University of Massachusetts Chan Medical School

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