His main research concerns Virology, Virus, Genetic enhancement, Molecular biology and Viral vector. His Virology study combines topics from a wide range of disciplines, such as Microvesicles, Plasmid and Transduction. His work deals with themes such as Neuroscience research, Blood–brain barrier and Gene delivery, which intersect with Virus.
His Genetic enhancement research includes themes of Vector and Bioinformatics. His Molecular biology study incorporates themes from Transgene, Gene silencing and Thymidine kinase, Herpes simplex virus. His research integrates issues of Cancer research and Precursor cell in his study of Viral vector.
Genetic enhancement, Molecular biology, Virology, Gene delivery and Virus are his primary areas of study. His Genetic enhancement research is multidisciplinary, incorporating perspectives in Cancer research, Vector, Adeno-associated virus, Pathology and Viral vector. His Molecular biology study also includes fields such as
His Cell biology study combines topics from a wide range of disciplines, such as Gene silencing, Gene expression and Huntingtin. His Virology research includes themes of Plasmid, Transfection, Transduction and Recombinant DNA. His studies examine the connections between Gene delivery and genetics, as well as such issues in Central nervous system, with regards to Sandhoff disease and Immunology.
His primary areas of study are Recombinant DNA, Virus, Genetic enhancement, Molecular biology and Virology. His Virus research is multidisciplinary, relying on both Vector and Cell culture. His Genetic enhancement research integrates issues from Systemic administration, Central nervous system, Ganglioside and Cell biology.
The Cell biology study which covers Transduction that intersects with Genetically modified mouse. His work deals with themes such as Dopaminergic and Real-time polymerase chain reaction, which intersect with Molecular biology. His research investigates the connection between Gene delivery and topics such as Spinal cord that intersect with problems in Lysosomal storage disease.
Miguel Sena-Esteves focuses on Genetic enhancement, Virus, Cell biology, Central nervous system and Recombinant DNA. His Genetic enhancement research is mostly focused on the topic Gene delivery. He combines subjects such as Plasmid, Glycogen storage disease type II, Glycogen, Vector and Genetically modified mouse with his study of Virus.
The concepts of his Cell biology study are interwoven with issues in Transgene, Gene silencing, Gene expression and Transduction. His study in Central nervous system is interdisciplinary in nature, drawing from both Huntingtin, Messenger RNA and Small interfering RNA. The Recombinant DNA study combines topics in areas such as Suspension culture, Transient transfection, Transfection, Virology and HEK 293 cells.
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Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
Skog J;Würdinger T;van Rijn S;Meijer Dh.
Nature Cell Biology (2008)
Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits
Marian DiFiglia;Miguel Sena-Esteves;Kathryn O. Chase;Ellen Sapp.
Proceedings of the National Academy of Sciences of the United States of America (2007)
Selective Deletion of Bdnf in the Ventromedial and Dorsomedial Hypothalamus of Adult Mice Results in Hyperphagic Behavior and Obesity
Thaddeus J Unger;German A Calderon;Leila C Bradley;Miguel Sena-Esteves.
The Journal of Neuroscience (2007)
Depletion of GGA3 Stabilizes BACE and Enhances β-Secretase Activity
Giuseppina Tesco;Young Ho Koh;Eugene L. Kang;Andrew N. Cameron.
Optimized large-scale production of high titer lentivirus vector pseudotypes.
Miguel Sena-Esteves;Jessica C. Tebbets;Sabine Steffens;Timothy Crombleholme.
Journal of Virological Methods (2004)
Adeno-associated virus vectors serotyped with AAV8 capsid are more efficient than AAV-1 or -2 serotypes for widespread gene delivery to the neonatal mouse brain.
M.L.D. Broekman;L.A. Comer;B.T. Hyman;M. Sena-Esteves.
Several rAAV Vectors Efficiently Cross the Blood–brain Barrier and Transduce Neurons and Astrocytes in the Neonatal Mouse Central Nervous System
Hongwei Zhang;Bin Yang;Xin Mu;Xin Mu;Seemin Seher Ahmed.
Molecular Therapy (2011)
Long-term survival of rats harboring brain neoplasms treated with ganciclovir and a herpes simplex virus vector that retains an intact thymidine kinase gene.
Efstathios J. Boviatsis;John S. Park;Miguel Sena-Esteves;Christof M. Kramm.
Cancer Research (1994)
Microvesicle-associated AAV vector as a novel gene delivery system.
Casey A. Maguire;Leonora Balaj;Sarada Sivaraman;Matheus H. W. Crommentuijn.
Molecular Therapy (2012)
Therapeutic Efficiency and Safety of a Second-Generation Replication-Conditional HSV1 Vector for Brain Tumor Gene Therapy
C. M. Kramm;M. Chase;U. Herrlinger;A. Jacobs.
Human Gene Therapy (1997)
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