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Biology and Biochemistry

D-Index
59
Citations
16930
World Ranking
12336
National Ranking
5282

Overview

Miguel Sena-Esteves is affiliated with the University of Massachusetts Chan Medical School in the United States. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine, with a particular focus on gene therapy and neurogenetic disorders.

The main fields of study in their work include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Their research covers subfields such as:

  • Molecular Biology
  • Genetics
  • Physiology
  • Neurology
  • Epidemiology

Key research topics addressed by their publications are:

  • Virus-based gene therapy research
  • Lysosomal Storage Disorders Research
  • Neurogenetic and Muscular Disorders Research
  • Viral Infectious Diseases and Gene Expression in Insects
  • RNA Interference and Gene Delivery
  • Viral gastroenteritis research and epidemiology
  • Amyotrophic Lateral Sclerosis Research

They have published frequently in the following venues:

  • Cold Spring Harbor Protocols
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Human Gene Therapy
  • Molecular Genetics and Metabolism
  • Molecular Therapy - Methods & Clinical Development

Frequent co-authors who have collaborated with Miguel Sena-Esteves include:

  • Heather Gray-Edwards
  • Douglas R. Martin
  • Ana Rita Batista
  • Guangping Gao
  • Terence R. Flotte

Among recent papers, notable publications authored or co-authored by Sena-Esteves are:

  • "AAV gene therapy for Tay-Sachs disease" (2022, Nature Medicine)
  • "Introducing Genes into Mammalian Cells: Viral Vectors" (2020, Cold Spring Harbor Protocols)
  • "Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons" (2022, Neuron)
  • "Redosing Adeno-Associated Virus Gene Therapy to the Central Nervous System" (2022, Human Gene Therapy)
  • "Pronounced Therapeutic Benefit of a Single Bidirectional AAV Vector Administered Systemically in Sandhoff Mice" (2020, Molecular Therapy)

Best Publications

  • Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

    Skog J;Würdinger T;van Rijn S;Meijer Dh

  • Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits

    Marian DiFiglia;Miguel Sena-Esteves;Kathryn O. Chase;Ellen Sapp

  • Selective Deletion of Bdnf in the Ventromedial and Dorsomedial Hypothalamus of Adult Mice Results in Hyperphagic Behavior and Obesity

    Thaddeus J Unger;German A Calderon;Leila C Bradley;Miguel Sena-Esteves

  • Depletion of GGA3 Stabilizes BACE and Enhances β-Secretase Activity

    Giuseppina Tesco;Young Ho Koh;Eugene L. Kang;Andrew N. Cameron

  • Optimized large-scale production of high titer lentivirus vector pseudotypes.

    Miguel Sena-Esteves;Jessica C. Tebbets;Sabine Steffens;Timothy Crombleholme

  • Several rAAV Vectors Efficiently Cross the Blood–brain Barrier and Transduce Neurons and Astrocytes in the Neonatal Mouse Central Nervous System

    Hongwei Zhang;Bin Yang;Xin Mu;Xin Mu;Seemin Seher Ahmed

  • Microvesicle-associated AAV vector as a novel gene delivery system.

    Casey A. Maguire;Leonora Balaj;Sarada Sivaraman;Matheus H. W. Crommentuijn

  • Adeno-associated virus vectors serotyped with AAV8 capsid are more efficient than AAV-1 or -2 serotypes for widespread gene delivery to the neonatal mouse brain.

    M.L.D. Broekman;L.A. Comer;B.T. Hyman;M. Sena-Esteves

  • Long-term survival of rats harboring brain neoplasms treated with ganciclovir and a herpes simplex virus vector that retains an intact thymidine kinase gene.

    Efstathios J. Boviatsis;John S. Park;Miguel Sena-Esteves;Christof M. Kramm

  • Neural Precursor Cells for Delivery of Replication-Conditional HSV-1 Vectors to Intracerebral Gliomas

    Ulrich Herrlinger;Ulrich Herrlinger;Christian Woiciechowski;Christian Woiciechowski;Miguel Sena-Esteves;Karen S. Aboody

  • Therapeutic Efficiency and Safety of a Second-Generation Replication-Conditional HSV1 Vector for Brain Tumor Gene Therapy

    C. M. Kramm;M. Chase;U. Herrlinger;A. Jacobs

  • Viral vectors for therapy of neurologic diseases.

    Sourav R. Choudhury;Eloise Hudry;Casey A. Maguire;Miguel Sena-Esteves

  • Brain-Derived Neurotrophic Factor Regulates Hedonic Feeding by Acting on the Mesolimbic Dopamine System

    Joshua W. Cordeira;Lauren Frank;Miguel Sena-Esteves;Emmanuel N. Pothos

  • Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice

    Fernando J Bustos;Estibaliz Ampuero;Nur Jury;Rodrigo Aguilar

  • Association of a missense change in the D2 dopamine receptor with myoclonus dystonia

    Christine Klein;Mitchell F. Brin;Patricia Kramer;Miguel Sena-Esteves

  • A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system

    Julia F. Alterman;Bruno M. D. C. Godinho;Matthew R. Hassler;Chantal M. Ferguson

  • Spinal projections of the A5, A6 (locus coeruleus), and A7 noradrenergic cell groups in rats.

    Eveline Bruinstroop;Georgina Cano;Veronique G.J.M. Vanderhorst;Judney C. Cavalcante

  • Induced Pluripotent Stem Cell Models of Progranulin-Deficient Frontotemporal Dementia Uncover Specific Reversible Neuronal Defects

    Sandra Almeida;Zhijun Zhang;Giovanni Coppola;Wenjie Mao

  • Gene transfer into the mammalian inner ear using HSV-1 and vaccinia virus vectors.

    Michael L Derby;Miguel Sena-Esteves;Xandra O Breakefield;David P Corey;David P Corey

  • Functional Coexpression of HSV-1 Thymidine Kinase and Green Fluorescent Protein: Implications for Noninvasive Imaging of Transgene Expression

    Andreas Jacobs;Michael Dubrovin;Jeff Hewett;Miguel Sena-Esteves

Frequent Co-Authors

Xandra O. Breakefield
Xandra O. Breakefield Harvard University
Guangping Gao
Guangping Gao University of Massachusetts Chan Medical School
Neil Aronin
Neil Aronin University of Massachusetts Chan Medical School
Bakhos A. Tannous
Bakhos A. Tannous Harvard University
Marian DiFiglia
Marian DiFiglia Harvard University
Thomas N. Seyfried
Thomas N. Seyfried Boston College
Christian Mueller
Christian Mueller University of Massachusetts Chan Medical School
E. Antonio Chiocca
E. Antonio Chiocca Brigham and Women's Hospital
James M. Wilson
James M. Wilson University of Pennsylvania
David J. Kwiatkowski
David J. Kwiatkowski Brigham and Women's Hospital

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