World's Best Scientists 2026 revealed!
Xandra O. Breakefield

Xandra O. Breakefield

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Best Female Scientists
2025
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Molecular Biology
USA
2023

D-Index & Metrics

Best Female Scientists

D-Index
146
Citations
89401
World Ranking
176
National Ranking
107

Medicine

D-Index
146
Citations
96016
World Ranking
1321
National Ranking
762

Xandra O. Breakefield publication distribution in Medicine in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Medicine in 2026. The highlighted bar marks where Xandra O. Breakefield sits on this spectrum.

101–120 publications: 5 scientists 121–140 publications: 26 scientists 141–160 publications: 73 scientists 161–180 publications: 155 scientists 181–200 publications: 230 scientists 201–220 publications: 363 scientists 221–240 publications: 487 scientists 241–260 publications: 545 scientists 261–280 publications: 722 scientists 281–300 publications: 768 scientists 301–320 publications: 834 scientists 321–340 publications: 895 scientists 341–360 publications: 922 scientists 361–380 publications: 838 scientists 381–400 publications: 861 scientists 401–420 publications: 918 scientists 421–440 publications: 806 scientists 441–460 publications: 771 scientists 461–480 publications: 751 scientists 481–500 publications: 713 scientists 501–520 publications: 617 scientists 521–540 publications: 611 scientists 541–560 publications: 537 scientists 561–580 publications: 504 scientists 581–600 publications: 509 scientists 601–620 publications: 396 scientists 621–640 publications: 386 scientists 641–660 publications: 371 scientists 661–680 publications: 340 scientists 681–700 publications: 336 scientists 701–720 publications: 307 scientists 721–740 publications: 259 scientists 741–760 publications: 230 scientists 761–780 publications: 228 scientists 781–800 publications: 217 scientists 801–820 publications: 204 scientists 821–840 publications: 186 scientists 841–860 publications: 177 scientists 861–880 publications: 155 scientists 881–900 publications: 139 scientists 901–920 publications: 145 scientists 921–940 publications: 116 scientists 941–960 publications: 133 scientists 961–980 publications: 91 scientists 981–1,000 publications: 96 scientists 1,001–1,020 publications: 77 scientists 1,021–1,040 publications: 70 scientists 1,041–1,060 publications: 63 scientists 1,061–1,080 publications: 77 scientists 1,081–1,100 publications: 49 scientists 1,101–1,120 publications: 54 scientists 1,121–1,140 publications: 49 scientists 1,141–1,160 publications: 51 scientists 1,161–1,180 publications: 35 scientists 1,181–1,200 publications: 39 scientists 1,201–1,220 publications: 26 scientists 1,221–1,240 publications: 37 scientists 1,241–1,260 publications: 36 scientists 1,261–1,280 publications: 27 scientists 1,281–1,300 publications: 32 scientists 1,301–1,320 publications: 28 scientists 1,321–1,340 publications: 17 scientists 1,341–1,360 publications: 30 scientists 1,361–1,380 publications: 28 scientists 1,381–1,400 publications: 17 scientists 1,401–1,420 publications: 21 scientists 1,421–1,440 publications: 15 scientists 1,441–1,460 publications: 12 scientists 1,461–1,480 publications: 12 scientists 1,481–1,500 publications: 18 scientists 1,501–1,520 publications: 14 scientists 1,521–1,540 publications: 17 scientists 1,541–1,560 publications: 15 scientists 1,561–1,580 publications: 6 scientists 1,581–1,600 publications: 2 scientists 1,601–1,620 publications: 12 scientists 1,621–1,640 publications: 11 scientists 1,641–1,660 publications: 8 scientists 1,661–1,680 publications: 5 scientists 1,681–1,700 publications: 5 scientists 1,701–1,720 publications: 10 scientists 1,721–1,740 publications: 12 scientists 1,741–1,760 publications: 14 scientists 1,761–1,780 publications: 6 scientists 1,781–1,795 publications: 5 scientists 1,796+ publications: 100 scientists
101 publications 1,796+

This scientist: 607 publications — 73rd percentile

73% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,796 publications or more.

Xandra O. Breakefield D-index placement in Medicine in 2026

The chart shows the D-index (discipline H-index) distribution of Medicine scientists ranked by Research.com in 2026. The highlighted bar marks where Xandra O. Breakefield sits on this spectrum.

70–71 D-Index: 226 scientists 72–73 D-Index: 391 scientists 74–75 D-Index: 574 scientists 76–77 D-Index: 730 scientists 78–79 D-Index: 891 scientists 80–81 D-Index: 972 scientists 82–83 D-Index: 1,027 scientists 84–85 D-Index: 1,003 scientists 86–87 D-Index: 960 scientists 88–89 D-Index: 970 scientists 90–91 D-Index: 922 scientists 92–93 D-Index: 839 scientists 94–95 D-Index: 808 scientists 96–97 D-Index: 779 scientists 98–99 D-Index: 668 scientists 100–101 D-Index: 611 scientists 102–103 D-Index: 630 scientists 104–105 D-Index: 513 scientists 106–107 D-Index: 541 scientists 108–109 D-Index: 445 scientists 110–111 D-Index: 429 scientists 112–113 D-Index: 400 scientists 114–115 D-Index: 393 scientists 116–117 D-Index: 318 scientists 118–119 D-Index: 302 scientists 120–121 D-Index: 287 scientists 122–123 D-Index: 255 scientists 124–125 D-Index: 256 scientists 126–127 D-Index: 252 scientists 128–129 D-Index: 230 scientists 130–131 D-Index: 179 scientists 132–133 D-Index: 168 scientists 134–135 D-Index: 163 scientists 136–137 D-Index: 159 scientists 138–139 D-Index: 134 scientists 140–141 D-Index: 134 scientists 142–143 D-Index: 118 scientists 144–145 D-Index: 109 scientists 146–147 D-Index: 106 scientists 148–149 D-Index: 74 scientists 150–151 D-Index: 79 scientists 152–153 D-Index: 80 scientists 154–155 D-Index: 87 scientists 156–157 D-Index: 57 scientists 158–159 D-Index: 74 scientists 160–161 D-Index: 69 scientists 162–163 D-Index: 60 scientists 164–165 D-Index: 53 scientists 166–167 D-Index: 39 scientists 168–169 D-Index: 42 scientists 170–171 D-Index: 32 scientists 172–173 D-Index: 39 scientists 174–175 D-Index: 40 scientists 176–177 D-Index: 28 scientists 178–179 D-Index: 19 scientists 180–181 D-Index: 23 scientists 182–183 D-Index: 31 scientists 184–185 D-Index: 18 scientists 186–187 D-Index: 20 scientists 188–189 D-Index: 22 scientists 190–191 D-Index: 13 scientists 192–193 D-Index: 21 scientists 194–195 D-Index: 12 scientists 196–197 D-Index: 12 scientists 198–199 D-Index: 14 scientists 200–201 D-Index: 15 scientists 202–203 D-Index: 13 scientists 204–205 D-Index: 10 scientists 206–207 D-Index: 8 scientists 208–209 D-Index: 4 scientists 210–211 D-Index: 12 scientists 212–213 D-Index: 11 scientists 214–215 D-Index: 10 scientists 216 D-Index: 4 scientists 217+ D-Index: 98 scientists
70 D-Index 217+

This scientist: 146 D-Index — 94th percentile

94% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 217 D-Index or more.

Research.com Recognitions

  • 2025 - Research.com Best Female Scientists Award
  • 2023 - Research.com Molecular Biology in United States Leader Award
  • 2013 - Fellow of the American Academy of Arts and Sciences

Overview

Xandra O. Breakefield is affiliated with Harvard University in the United States. Their research primarily falls under the broad field of Biochemistry, Genetics and Molecular Biology, with a focus on specific subfields including Molecular Biology, Cancer Research, Pulmonary and Respiratory Medicine, Immunology, and Genetics.

The scientist's work extensively covers topics related to extracellular vesicles in disease, RNA interference and gene delivery, and microRNA in disease regulation. Other notable research interests include ferroptosis and cancer prognosis, glycosylation and glycoproteins research, immunotherapy and immune responses, as well as immune cells in cancer.

Key recent publications by Xandra O. Breakefield include the following:

  • Glioblastomas exploit truncated O - linked glycans for local and distant immune modulation via the macrophage galactose-type lectin, 2020, Proceedings of the National Academy of Sciences
  • Extracellular Vesicle-Mediated Bilateral Communication between Glioblastoma and Astrocytes, 2020, Trends in Neurosciences
  • Engineered EVs designed to target diseases of the CNS, 2023, Journal of Controlled Release
  • TAF1 Transcripts and Neurofilament Light Chain as Biomarkers for X-linked Dystonia-Parkinsonism, 2020, Movement Disorders
  • Versatile Role of Rab27a in Glioma: Effects on Release of Extracellular Vesicles, Cell Viability, and Tumor Progression, 2020, Frontiers in Molecular Biosciences

Frequent publication venues where their work appears include Neuro-Oncology Advances and Neurology, each featuring two publications, as well as the Proceedings of the National Academy of Sciences, Trends in Neurosciences, and Journal of Controlled Release.

Collaborations have been a significant aspect of their research, with frequent co-authors including Marike L. D. Broekman, Erik R. Abels, Lisa Nieland, Koen Breyne, and Thomas S. van Solinge.

Xandra O. Breakefield has been recognized as a Fellow of the American Academy of Arts and Sciences since 2013.

Best Publications

  • Minimal information for studies of extracellular vesicles 2018 (MISEV2018) : a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

    Clotilde Théry;Kenneth W. Witwer;Elena Aikawa;Maria Jose Alcaraz

  • Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

    Skog J;Würdinger T;van Rijn S;Meijer Dh

  • Extracellular vesicles: biology and emerging therapeutic opportunities

    Samir El Andaloussi;Imre Mäger;Imre Mäger;Xandra O. Breakefield;Matthew J. A. Wood

  • Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A

    H. G. Brunner;M. Nelen;X. O. Breakefield;H. H. Ropers

  • Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas.

    Karen S. Aboody;Alice Brown;Nikolai G. Rainov;Kate A. Bower

  • New Technologies for Analysis of Extracellular Vesicles

    Huilin Shao;Hyungsoon Im;Cesar M. Castro;Xandra Breakefield

  • Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake

    Erik R. Abels;Erik R. Abels;Xandra O. Breakefield

  • Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation

    Hina Kalra;Richard J. Simpson;Hong Ji;Elena Aikawa

  • RNA delivery by extracellular vesicles in mammalian cells and its applications.

    Killian P. O’Brien;Koen Breyne;Stefano Ughetto;Stefano Ughetto;Louise C. Laurent

  • Extracellular Vesicles: Unique Intercellular Delivery Vehicles.

    Sybren L.N. Maas;Xandra O. Breakefield;Alissa M. Weaver

  • Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences

    Leonora Balaj;Ryan Lessard;Lixin Dai;Yoon Jae Cho

  • The early-onset torsion dystonia gene (DYT1) encodes an ATP-binding protein

    Laurie J. Ozelius;Jeffrey W. Hewett;Curtis E. Page;Susan B. Bressman

  • Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study

    MikoŁaj P. Zaborowski;Leonora Balaj;Xandra O. Breakefield;Charles P. Lai

  • Advances in therapeutic applications of extracellular vesicles

    Oscar P. B. Wiklander;Meadhbh Á. Brennan;Meadhbh Á. Brennan;Jan Lötvall;Xandra O. Breakefield

  • Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer

    Jonas Nilsson;Johan Skog;Annika Nordstrand;Vladimir Baranov

  • Codon-optimized Gaussia luciferase cDNA for mammalian gene expression in culture and in vivo.

    Bakhos A. Tannous;Dong-Eog Kim;Juliet L. Fernandez;Ralph Weissleder

  • Dynamic biodistribution of extracellular vesicles in vivo using a multimodal imaging reporter.

    Charles P. Lai;Osama Mardini;Maria Ericsson;Shilpa Prabhakar

  • Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy

    Huilin Shao;Jaehoon Chung;Leonora Balaj;Alain Charest

  • Immunocytochemical demonstration of monoamine oxidase B in brain astrocytes and serotonergic neurons

    Pat Levitt;John E. Pintar;Xandra O. Breakefield

  • Microfluidic isolation and transcriptome analysis of serum microvesicles

    Chihchen Chen;Johan Skog;Chia-Hsien Hsu;Ryan T. Lessard

Frequent Co-Authors

Laurie J. Ozelius
Laurie J. Ozelius Harvard University
Miguel Sena-Esteves
Miguel Sena-Esteves University of Massachusetts Chan Medical School
Ralph Weissleder
Ralph Weissleder Harvard University
James F. Gusella
James F. Gusella Harvard University
Patricia L. Kramer
Patricia L. Kramer Oregon Health & Science University
Bakhos A. Tannous
Bakhos A. Tannous Harvard University
E. Antonio Chiocca
E. Antonio Chiocca Brigham and Women's Hospital
Christine Klein
Christine Klein University of Lübeck
Mitchell F. Brin
Mitchell F. Brin Allergan (Ireland)
Bob S. Carter
Bob S. Carter Harvard University

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