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Neuroscience

D-Index
91
Citations
28223
World Ranking
1073
National Ranking
561

Research.com Recognitions

  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2012 - Fellow, National Academy of Inventors

Overview

Howard J. Federoff is affiliated with the University of California, Irvine in the United States. Their research spans multiple disciplines within medicine and neuroscience, focusing on molecular biology, neurology, and cellular and molecular neuroscience.

The scientist's work addresses several main topics including:

  • Alzheimer's disease research and treatments
  • Parkinson's Disease Mechanisms and Treatments
  • Nerve injury and regeneration
  • Metabolomics and Mass Spectrometry Studies
  • Autism Spectrum Disorder Research
  • Neurological disorders and treatments
  • Pluripotent Stem Cells Research

Frequent publication venues for their research include:

  • Journal of Parkinson s Disease
  • Alzheimer s Research & Therapy
  • Journal of Alzheimer s Disease
  • Brain
  • npj Regenerative Medicine

Selected recent papers authored or co-authored by Howard J. Federoff illustrate the focus on neurodegenerative disorders:

  • "GDNF and Parkinson's Disease: Where Next? A Summary from a Recent Workshop," 2020, Journal of Parkinson s Disease
  • "Nigrostriatal tau pathology in parkinsonism and Parkinson's disease," 2023, Brain
  • "Optimizing maturity and dose of iPSC-derived dopamine progenitor cell therapy for Parkinson's disease," 2022, npj Regenerative Medicine
  • "Association of plasma YKL-40 with brain amyloid-β levels, memory performance, and sex in subjective memory complainers," 2020, Neurobiology of Aging
  • "A retrotransposon storm marks clinical phenoconversion to late-onset Alzheimer's disease," 2022, GeroScience

Howard J. Federoff has collaborated frequently with several researchers, including:

  • Massimo S. Fiandaca
  • Mark Mapstone
  • Patrizia A. Chiesa
  • Harald Hampel
  • Andrea Vergallo

Throughout their career, Howard J. Federoff has been recognized as a Fellow of the American Association for the Advancement of Science (AAAS) and as a Fellow of the National Academy of Inventors, both awarded in 2012.

Best Publications

  • Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor.

    Seong Woon Yu;Hongmin Wang;Marc F. Poitras;Carmen Coombs

  • Plasma phospholipids identify antecedent memory impairment in older adults

    Mark Mapstone;Amrita K Cheema;Massimo S Fiandaca;Xiaogang Zhong

  • Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

    Massimo S. Fiandaca;Dimitrios Kapogiannis;Mark Mapstone;Adam Boxer

  • PGC-1α, A Potential Therapeutic Target for Early Intervention in Parkinson’s Disease

    Bin Zheng;Zhixiang Liao;Joseph J. Locascio;Kristen A. Lesniak

  • Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss.

    A.I Brooks;C.A Chadwick;H.A Gelbard;D.A Cory-Slechta

  • Synuclein activates microglia in a model of Parkinson’s Disease

    Xiaomin Su;Kathleen A. Maguire-Zeiss;Rita Giuliano;Landa Prifti

  • Regulation of neuronal traits by a novel transcriptional complex.

    Nurit Ballas;Elena Battaglioli;Fouad Atouf;Maria E. Andres

  • Expression of bcl-2 From a Defective Herpes Simplex Virus–1 Vector Limits Neuronal Death in Focal Cerebral Ischemia

    Matthew D. Linnik;Peter Zahos;Michael D. Geschwind;Howard J. Federoff

  • Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

    Byoung Dae Lee;Joo Ho Shin;Jackalina Vankampen;Leonard Petrucelli

  • Regulated release and polarized localization of brain-derived neurotrophic factor in hippocampal neurons.

    Laurie J. Goodman;Janet Valverde;Filip Lim;Michael D. Geschwind

  • A focus on the synapse for neuroprotection in Alzheimer disease and other dementias

    Paul Coleman;Howard Federoff;Roger Kurlan

  • Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death.

    Hongmin Wang;Seong Woon Yu;David W. Koh;Jasmine Lew

  • Nerve growth factor administration protects against experimental diabetic sensory neuropathy

    Stuart C. Apfel;Joseph C. Arezzo;Michael Brownlee;Howard Federoff

  • Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice.

    Michelle C Janelsins;Michael A Mastrangelo;Salvatore Oddo;Frank M LaFerla

  • Behavioral and neurochemical effects of wild-type and mutated human α-synuclein in transgenic mice

    Eric K. Richfield;Mona J. Thiruchelvam;Deborah A. Cory-Slechta;Charles Wuertzer

  • Nerve Growth Factor Prevents Both Neuroretinal Programmed Cell Death and Capillary Pathology in Experimental Diabetes

    Hans-Peter Hammes;Howard J. Federoff;Michael Brownlee

  • Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson’s Disease

    Sudhakar R. Subramaniam;Howard J. Federoff

  • Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins

    Mandy Jackson;Wei Song;Mu Ya Liu;Lin Jin

  • Hypoxia-Inducible Factor-1α Mediates Hypoxia-Induced Delayed Neuronal Death That Involves p53

    Marc W. Halterman;Craig C. Miller;Howard J. Federoff

  • GAP-43 gene expression during development: persistence in a distinctive set of neurons in the mature central nervous system.

    Suzanne M. De la Monte;Howard J. Federoff;Howard J. Federoff;Shi-Chung Ng;Shi-Chung Ng;Ed Grabczyk;Ed Grabczyk

  • Current treatment for Alzheimer disease and future prospects.

    Pierre N Tariot;Howard J Federoff

Frequent Co-Authors

Krystof S. Bankiewicz
Krystof S. Bankiewicz The Ohio State University
Stephen Dewhurst
Stephen Dewhurst University of Rochester
Jamie L. Eberling
Jamie L. Eberling Michael J. Fox Foundation
Paul D. Coleman
Paul D. Coleman Arizona State University
Hinrich Staecker
Hinrich Staecker University of Kansas
Andrew B. Singleton
Andrew B. Singleton National Institutes of Health
Jeffrey L. Cummings
Jeffrey L. Cummings University of Nevada, Las Vegas
Nicola Toschi
Nicola Toschi University of Rome Tor Vergata
Filippo Sean Giorgi
Filippo Sean Giorgi University of Pisa
Roberto Ceravolo
Roberto Ceravolo University of Pisa

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