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Neuroscience

D-Index
73
Citations
16138
World Ranking
2236
National Ranking
1062

Overview

Yehoash Raphael is affiliated with the University of Michigan-Ann Arbor in the United States. Their research primarily focuses on neuroscience, with a strong emphasis on sensory systems, cognitive neuroscience, and otorhinolaryngology. The main topics covered by their work include hearing, cochlea, tinnitus, genetics, hearing loss and rehabilitation, ear surgery and otitis media, noise effects and management, congenital ear and nasal anomalies, connexins and lens biology, and acoustic wave phenomena research.

Raphael has contributed significantly to the field with numerous publications, particularly in the area of hearing research. Their frequent publication venues include Hearing Research, bioRxiv (Cold Spring Harbor Laboratory), the Journal of the Association for Research in Otolaryngology, eLife, and Scientific Reports.

Their recent papers demonstrate an ongoing investigation into hair cell regeneration, gene therapy, and cochlear health. These include:

  • Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals (2022, eLife)
  • Combinatorial Atoh1 and Gfi1 induction enhances hair cell regeneration in the adult cochlea (2020, Scientific Reports)
  • GJB2 gene therapy and conditional deletion reveal developmental stage-dependent effects on inner ear structure and function (2021, Molecular Therapy - Methods & Clinical Development)
  • Gene therapy for hair cell regeneration: Review and new data (2020, Hearing Research)
  • Cochlear Health and Cochlear-implant Function (2023, Journal of the Association for Research in Otolaryngology)

Raphael collaborates frequently with several coauthors, including Donald L. Swiderski, Lisa A. Beyer, Deborah J. Colesa, Bryan E. Pfingst, and Diane M. Prieskorn. These collaborations have contributed to advancing knowledge in the areas of hearing loss mechanisms and therapeutic approaches.

Best Publications

  • Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals

    Masahiko Izumikawa;Ryosei Minoda;Ryosei Minoda;Kohei Kawamoto;Karen A Abrashkin

  • Surface modification of neural recording electrodes with conducting polymer/biomolecule blends

    Xinyan Cui;Valerie A. Lee;Yehoash Raphael;James A. Wiler

  • Math1 Gene Transfer Generates New Cochlear Hair Cells in Mature Guinea Pigs In Vivo

    Kohei Kawamoto;Shin Ichi Ishimoto;Ryosei Minoda;Ryosei Minoda;Douglas E. Brough

  • Correction of deafness in shaker-2 mice by an unconventional myosin in a BAC transgene

    Frank J. Probst;Robert A. Fridell;Yehoash Raphael;Thomas L. Saunders

  • COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness

    Saskia F. Heeringa;Gil Chernin;Moumita Chaki;Weibin Zhou

  • Claudin 14 knockout mice, a model for autosomal recessive deafness DFNB29, are deaf due to cochlear hair cell degeneration

    Tamar Ben-Yosef;Inna A. Belyantseva;Thomas L. Saunders;Elizabeth D. Hughes

  • Structure and innervation of the cochlea.

    Yehoash Raphael;Richard A Altschuler

  • Neurotrophins can enhance spiral ganglion cell survival after inner hair cell loss

    Josef M. Miller;David H. Chi;Leonard J. O'Keeffe;Paul Kruszka

  • Aminoglycoside ototoxicity in adult CBA, C57BL and BALB mice and the Sprague-Dawley rat

    Wei Jing Wu;Su Hua Sha;John D. McLaren;Kohei Kawamoto

  • New hair cells arise from supporting cell conversion in the acoustically damaged chick inner ear

    Henry J. Adler;Yehoash Raphael

  • Evidence for supporting cell mitosis in response to acoustic trauma in the avian inner ear

    Yehoash Raphael

  • Role of glutathione in protection against noise-induced hearing loss

    Tatsuya Yamasoba;Alfred L Nuttall;Alfred L Nuttall;Craig Harris;Yehoash Raphael

  • Antioxidant gene therapy can protect hearing and hair cells from ototoxicity.

    Kohei Kawamoto;Su Hua Sha;Ryosei Minoda;Ryosei Minoda;Masahiko Izumikawa;Masahiko Izumikawa

  • Loss of Chd7 function in gene-trapped reporter mice is embryonic lethal and associated with severe defects in multiple developing tissues.

    Elizabeth A. Hurd;Patrice L. Capers;Marsha N. Blauwkamp;Meredith E. Adams

  • Adenoviral-mediated gene transfer into guinea pig cochlear cells in vivo

    Yehoash Raphael;Juan C. Frisancho;Blake J. Roessler

  • Spiral ganglion neurons are protected from degeneration by GDNF gene therapy.

    Masao Yagi;Sho Kanzaki;Kohei Kawamoto;Brian Shin

  • Spontaneous hair cell regeneration in the mouse utricle following gentamicin ototoxicity

    Kohei Kawamoto;Masahiko Izumikawa;Masahiko Izumikawa;Lisa A. Beyer;Graham M. Atkin

  • Hair Cell Protection from Aminoglycoside Ototoxicity by Adenovirus-Mediated Overexpression of Glial Cell Line-Derived Neurotrophic Factor

    Masao Yagi;Ella Magal;Zeqi Sheng;Kathleen A. Ang

  • Glial cell line-derived neurotrophic factor and chronic electrical stimulation prevent VIII cranial nerve degeneration following denervation.

    Sho Kanzaki;Timo Stöver;Kohei Kawamoto;Kohei Kawamoto;Diane M. Prieskorn

  • Reorganization of cytoskeletal and junctional proteins during cochlear hair cell degeneration.

    Yehoash Raphael;Richard A. Altschuler

Frequent Co-Authors

David F. Dolan
David F. Dolan University of Michigan–Ann Arbor
Josef M. Miller
Josef M. Miller University of Michigan–Ann Arbor
Richard A. Altschuler
Richard A. Altschuler University of Michigan–Ann Arbor
Bryan E. Pfingst
Bryan E. Pfingst University of Michigan–Ann Arbor
Sally A. Camper
Sally A. Camper University of Michigan–Ann Arbor
David C. Martin
David C. Martin University of Delaware
Karen B. Avraham
Karen B. Avraham Tel Aviv University
Thomas B. Friedman
Thomas B. Friedman National Institutes of Health
Inna A. Belyantseva
Inna A. Belyantseva National Institutes of Health
Alfred L. Nuttall
Alfred L. Nuttall Oregon Health & Science University

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