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Karen B. Avraham

Karen B. Avraham

D-Index & Metrics

Genetics

D-Index
64
Citations
17128
World Ranking
2773
National Ranking
23

Research.com Recognitions

  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Karen B. Avraham is affiliated with Tel Aviv University in Israel and focuses their research primarily within the fields of biochemistry, genetics, and molecular biology, as well as neuroscience. Their work spans a range of molecular and cellular topics related to hearing and auditory disorders.

The main subfields of study they contribute to include:

  • Molecular Biology
  • Sensory Systems
  • Genetics
  • Cancer Research
  • Cell Biology

Their research interests cover several key topics such as hearing, cochlea, tinnitus, and genetics; RNA regulation and disease; cancer-related molecular mechanisms; ear surgery and otitis media; vestibular and auditory disorders; RNA and protein synthesis mechanisms; and genomics and rare diseases.

Recent publications by Karen B. Avraham include:

  • Neonatal AAV gene therapy rescues hearing in a mouse model of SYNE4 deafness (2020), published in EMBO Molecular Medicine
  • Mechanical forces drive ordered patterning of hair cells in the mammalian inner ear (2020), published in Nature Communications
  • Genomic analysis of inherited hearing loss in the Palestinian population (2020), published in Proceedings of the National Academy of Sciences
  • Disease-specific ACMG/AMP guidelines improve sequence variant interpretation for hearing loss (2021), published in Genetics in Medicine
  • Auditory Performance in Recovered SARS-COV-2 Patients (2020), published in Otology & Neurotology

Frequent co-authors collaborating with Karen B. Avraham include:

  • Shahar Taiber
  • Zippora Brownstein
  • Amiel A. Dror
  • Mor Bordeynik-Cohen
  • Tal Koffler-Brill

They have published multiple articles in well-known venues such as bioRxiv (Cold Spring Harbor Laboratory), Human Genetics, EMBO Molecular Medicine, Proceedings of the National Academy of Sciences, and Otology & Neurotology, demonstrating an extensive contribution to auditory and genetic research literature.

Karen B. Avraham is recognized as a member of the European Molecular Biology Organization (EMBO), indicating association with a broader scientific community dedicated to molecular biology research.

Best Publications

  • Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally

    Eugene E Varfolomeev;Marcus Schuchmann;Victor Luria;Nuchanard Chiannilkulchai

  • Genome-wide, large-scale production of mutant mice by ENU mutagenesis

    M. H. Hrabe de Angelis;H. Flaswinkel;H. Fuchs;B. Rathkolb

  • GJB2 mutations and degree of hearing loss: a multicenter study.

    Rikkert L. Snoeckx;Patrick L M Huygen;Delphine Feldmann;Sandrine Marlin

  • The mouse Snell's waltzer deafness gene encodes an unconventional myosin required for structural integrity of inner ear hair cells

    Karen B. Avraham;Tama Hasson;Karen P. Steel;David M. Kingsley

  • Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome.

    Charles J. Epstein;Karen B. Avraham;Michael Lovett;Sandra Smith

  • A novel deletion involving the connexin-30 gene, del(GJB6-d13s1854), found in trans with mutations in the GJB2 gene (connexin-26) in subjects with DFNB1 non-syndromic hearing impairment

    F. J. Del Castillo;M. Rodriguez-Ballesteros;A. Alvarez;T. Hutchin

  • Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans.

    Oz Vahava;Robert Morell;Eric D. Lynch;Sigal Weiss

  • Expert specification of the ACMG/AMP variant interpretation guidelines for genetic hearing loss.

    Andrea M Oza;Andrea M Oza;Marina T DiStefano;Marina T DiStefano;Sarah E Hemphill;Brandon J Cushman

  • Prevalence and Evolutionary Origins of the del(GJB6-D13S1830) Mutation in the DFNB1 Locus in Hearing-Impaired Subjects: a Multicenter Study

    Ignacio Del Castillo;Miguel A. Moreno-Pelayo;Francisco J. Del Castillo;Zippora Brownstein

  • Whole Exome Sequencing and Homozygosity Mapping Identify Mutation in the Cell Polarity Protein GPSM2 as the Cause of Nonsyndromic Hearing Loss DFNB82

    Tom Walsh;Hashem Shahin;Tal Elkan-Miller;Ming K. Lee

  • Role of myosin VI in the differentiation of cochlear hair cells.

    Tim Self;Tama Sobe;Neal G. Copeland;Nancy A. Jenkins

  • Down's syndrome: Abnormal neuromuscular junction in tongue of transgenic mice with elevated levels of human Cu/Zn-superoxide dismutase

    Karen B. Avraham;Michael Schickler;Dan Sapoznikov;Rena Yarom

  • MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice, is mutated in autosomal dominant nonsyndromic hearing loss

    Salvatore Melchionda;Nadav Ahituv;Luigi Bisceglia;Tama Sobe

  • Beethoven, a mouse model for dominant, progressive hearing loss DFNA36.

    Sarah Vreugde;Alexandra Erven;Corné J. Kros;Walter Marcotti

  • From flies' eyes to our ears: Mutations in a human class III myosin cause progressive nonsyndromic hearing loss DFNB30

    Tom Walsh;Vanessa Walsh;Sarah Vreugde;Ronna Hertzano

  • Hearing Loss: Mechanisms Revealed by Genetics and Cell Biology

    Amiel A. Dror;Karen B. Avraham

  • Transcription profiling of inner ears from Pou4f3ddl/ddl identifies Gfi1 as a target of the Pou4f3 deafness gene

    Ronna Hertzano;Ronna Hertzano;Mireille Montcouquiol;Sharon Rashi-Elkeles;Rani Elkon

  • The Notch ligand Jagged1 is required for inner ear sensory development

    A. E. Kiernan;N. Ahituv;H. Fuchs;Rudi Balling

  • Targeted genomic capture and massively parallel sequencing to identify genes for hereditary hearing loss in Middle Eastern families.

    Zippora Brownstein;Lilach M Friedman;Hashem Shahin;Varda Oron-Karni

  • Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22.

    Ingrid Zwaenepoel;Mirna Mustapha;Michel Leibovici;Elisabeth Verpy

Frequent Co-Authors

Mary Claire King
Mary Claire King University of Washington
Tom Walsh
Tom Walsh University of Washington
Mordechai Shohat
Mordechai Shohat Tel Aviv University
Yoram Groner
Yoram Groner Weizmann Institute of Science
Karen P. Steel
Karen P. Steel King's College London
Neal G. Copeland
Neal G. Copeland The University of Texas MD Anderson Cancer Center
Ming K. Lee
Ming K. Lee University of Washington
Nancy A. Jenkins
Nancy A. Jenkins The University of Texas MD Anderson Cancer Center
Thomas B. Friedman
Thomas B. Friedman National Institutes of Health
Heidi L. Rehm
Heidi L. Rehm Brigham and Women's Hospital

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