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Genetics

D-Index
81
Citations
24035
World Ranking
1525
National Ranking
194

Research.com Recognitions

  • 2020 - Fellow of the American Academy of Arts and Sciences
  • 2009 - Fellow of the Royal Society, United Kingdom

Overview

Karen P. Steel is a researcher affiliated with King's College London in the United Kingdom. Their work primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Neuroscience, with significant contributions in related subfields such as Molecular Biology, Sensory Systems, Cognitive Neuroscience, Neurology, and Genetics.

Their research focuses on several main topics, including Hearing, Cochlea, Tinnitus, Genetics; RNA regulation and disease; Hearing Loss and Rehabilitation; Vestibular and auditory disorders; CRISPR and Genetic Engineering; RNA Research and Splicing; and Genomics and Chromatin Dynamics.

Frequent publication venues for Karen P. Steel include bioRxiv (Cold Spring Harbor Laboratory), Hearing Research, Zenodo (CERN European Organization for Nuclear Research), PLoS ONE, and Proceedings of the National Academy of Sciences.

Their recent papers include the following:

  • A resource of targeted mutant mouse lines for 5,061 genes, 2021, Nature Genetics
  • Translational and interdisciplinary insights into presbyacusis: A multidimensional disease, 2020, Hearing Research
  • Genetic determinants of micronucleus formation in vivo, 2024, Nature
  • Hearing impairment due to Mir183/96/182 mutations suggests both loss-of-function and gain-of-function effects, 2020, Disease Models & Mechanisms
  • Functional analysis of candidate genes from genome-wide association studies of hearing, 2020, Hearing Research

Frequent co-authors of Karen P. Steel include Morag A. Lewis, Neil J. Ingham, Chiara Chiereghin, Michela Robusto, and Susana Caetano.

They have been recognized with awards including Fellow of the Royal Society, United Kingdom (2009) and Fellow of the American Academy of Arts and Sciences (2020).

Best Publications

  • Defective myosin VIIA gene responsible for Usher syndrome type 1B

    Dominique Well;Stéphane Blanchard;Josseline Kaplan;Parry Guilford

  • A type VII myosin encoded by the mouse deafness gene shaker-1.

    F. Gibson;J. Walsh;P. Mburu;A. Varela

  • A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.

    P M Nolan;J Peters;M Strivens;D Rogers

  • Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse.

    John A. Curtin;Elizabeth Quint;Vicky Tsipouri;Ruth M. Arkell

  • Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss.

    Ángeles Mencía;Silvia Modamio-Høybjør;Nick Redshaw;Matías Morín

  • Sox2 is required for sensory organ development in the mammalian inner ear

    Amy E. Kiernan;Anna L. Pelling;Keith K. H. Leung;Anna S. P. Tang

  • The mouse Snell's waltzer deafness gene encodes an unconventional myosin required for structural integrity of inner ear hair cells

    Karen B. Avraham;Tama Hasson;Karen P. Steel;David M. Kingsley

  • TRP-2/DT, a new early melanoblast marker, shows that steel growth factor (c-kit ligand) is a survival factor.

    Karen P Steel;Duncan R. Davidson;Ian Jackson

  • Mutations in the myosin VIIA gene cause non-syndromic recessive deafness.

    X. Z. Liu;J. Walsh;P. Mburu;J. Kendrick-Jones

  • A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains

    Michelle M Simon;Simon Greenaway;Jacqueline K White;Helmut Fuchs

  • Wnt5a functions in planar cell polarity regulation in mice

    Dong Qian;Chonnettia Jones;Agnieszka Rzadzinska;Sharayne Mark

  • Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes

    Jacqueline K White;Anna-Karin Gerdin;Natasha A Karp;Ed Ryder

  • Another role for melanocytes: their importance for normal stria vascularis development in the mammalian inner ear.

    K.P. Steel;C. Barkway

  • Mutations in Cdh23, encoding a new type of cadherin, cause stereocilia disorganization in waltzer, the mouse model for Usher syndrome type 1D.

    Federica Di Palma;Ralph H. Holme;Elizabeth C. Bryda;Inna A. Belyantseva

  • Autosomal dominant non-syndromic deafness caused by a mutation in the myosin VIIA gene

    Xue Zhong Liu;James Walsh;Yuya Tamagawa;Ken Kitamura

  • A genetic approach to understanding auditory function.

    Karen P. Steel;Corné J. Kros

  • Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31.

    Philomena Mburu;Mirna Mustapha;Anabel Varela;Dominique Weil

  • An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice.

    Morag A Lewis;Elizabeth Quint;Anne M Glazier;Helmut Fuchs

  • Shaker-1 mutations reveal roles for myosin VIIA in both development and function of cochlear hair cells

    Tim Self;Mary Mahony;Jane Fleming;James Walsh

  • Myosin VIIa Participates in Opsin Transport through The Photoreceptor Cilium

    Xinran Liu;Igor P. Udovichenko;Stephen D.M. Brown;Karen P. Steel

Frequent Co-Authors

Steve D.M. Brown
Steve D.M. Brown Medical Research Council
Helmut Fuchs
Helmut Fuchs Helmholtz Zentrum München
Martin Hrabé de Angelis
Martin Hrabé de Angelis Technical University of Munich
Walter Marcotti
Walter Marcotti University of Sheffield
David J. Adams
David J. Adams Wellcome Sanger Institute
David S. Williams
David S. Williams University of California, Los Angeles
Corné J. Kros
Corné J. Kros University of Sussex
Allan Bradley
Allan Bradley University of Cambridge
Karen B. Avraham
Karen B. Avraham Tel Aviv University
Joanne Cable
Joanne Cable Cardiff University

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