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Genetics

D-Index
81
Citations
30327
World Ranking
1508
National Ranking
192

Research.com Recognitions

  • 2015 - Fellow of the Royal Society, United Kingdom

Overview

Steve D.M. Brown is affiliated with the Medical Research Council in the United Kingdom. Their research spans multiple areas within biochemistry, genetics, and molecular biology, with a significant focus on neuroscience and sensory systems. The scientist's work encompasses genetics, molecular biology, neurology, and otorhinolaryngology as key subfields.

Their research topics include:

  • Hearing, cochlea, tinnitus, genetics
  • Molecular biology techniques and applications
  • Vestibular and auditory disorders
  • RNA and protein synthesis mechanisms
  • Ear surgery and otitis media
  • CRISPR and genetic engineering
  • Animal genetics and reproduction

Steve D.M. Brown has contributed extensively to the scientific literature, with notable papers including:

  • A resource of targeted mutant mouse lines for 5,061 genes, 2021, Nature Genetics
  • Age-related changes in the biophysical and morphological characteristics of mouse cochlear outer hair cells, 2020, The Journal of Physiology
  • Advances in mouse genetics for the study of human disease, 2021, Human Molecular Genetics
  • Pathophysiological changes in inner hair cell ribbon synapses in the ageing mammalian cochlea, 2020, The Journal of Physiology
  • Loss of Baiap2l2 destabilizes the transducing stereocilia of cochlear hair cells and leads to deafness, 2020, The Journal of Physiology

Frequent co-authors with whom Steve D.M. Brown has collaborated include:

  • Sara Wells
  • Yann Hérault
  • Ann-Marie Mallon
  • Colin McKerlie
  • Lauryl M. J. Nutter

Frequent venues for publication by this scientist are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Physiology
  • PLoS Genetics
  • Frontiers in Genetics
  • Mammalian Genome

In addition to journal articles, Steve D.M. Brown has published books, including a title in 2023 called Blockchain Applications in Food Supply Chain Management, released by Springer Nature.

The scientist was awarded the honor of Fellow of the Royal Society, United Kingdom in 2015.

Best Publications

  • Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)

    S. D. Bentley;K. F. Chater;A.-M. Cerdeño-Tárraga;G. L. Challis;G. L. Challis

  • The genome sequence of Schizosaccharomyces pombe

    V. Wood;R. Gwilliam;M.A. Rajandream;M. Lyne

  • High-throughput discovery of novel developmental phenotypes

    Mary E. Dickinson;Ann M. Flenniken;Xiao Ji;Lydia Teboul

  • Defective myosin VIIA gene responsible for Usher syndrome type 1B

    Dominique Well;Stéphane Blanchard;Josseline Kaplan;Parry Guilford

  • α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

    Ashley R. Winslow;Chien-Wen Chen;Silvia Corrochano;Abraham Acevedo-Arozena

  • Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment

    Derek C. Rogers;E.M.C. Fisher;S.D.M. Brown;J. Peters

  • A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.

    P M Nolan;J Peters;M Strivens;D Rogers

  • Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse.

    John A. Curtin;Elizabeth Quint;Vicky Tsipouri;Ruth M. Arkell

  • Mutations in the myosin VIIA gene cause non-syndromic recessive deafness.

    X. Z. Liu;J. Walsh;P. Mburu;J. Kendrick-Jones

  • A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains

    Michelle M Simon;Simon Greenaway;Jacqueline K White;Helmut Fuchs

  • Dynein mutations impair autophagic clearance of aggregate-prone proteins.

    Brinda Ravikumar;Abraham Acevedo-Arozena;Sara Imarisio;Zdenek Berger

  • The mouse ascending: perspectives for human-disease models.

    Nadia Alicia Rosenthal;Steve Brown

  • Mutations in α-Tubulin Cause Abnormal Neuronal Migration in Mice and Lissencephaly in Humans

    David A. Keays;Guoling Tian;Karine Poirier;Guo Jen Huang

  • Autosomal dominant non-syndromic deafness caused by a mutation in the myosin VIIA gene

    Xue Zhong Liu;James Walsh;Yuya Tamagawa;Ken Kitamura

  • Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31.

    Philomena Mburu;Mirna Mustapha;Anabel Varela;Dominique Weil

  • Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits.

    Matthias Groszer;David A. Keays;Robert M.J. Deacon;Joseph P. de Bono

  • The mammalian gene function resource: the international knockout mouse consortium

    Allan Bradley;Konstantinos Anastassiadis;Abdelkader Ayadi;James F. Battey

  • Genetic analysis of the mouse brain proteome

    Joachim Klose;Christina Nock;Marion Herrmann;Kai Stühler

  • Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk.

    E.L. Duncan;P. Danoy;J.P. Kemp;P.J. Leo

  • The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data

    Gautier Koscielny;Gagarine Yaikhom;Vivek Iyer;Terrence F. Meehan

Frequent Co-Authors

Karen P. Steel
Karen P. Steel King's College London
Roger D. Cox
Roger D. Cox Medical Research Council
Colin McKerlie
Colin McKerlie Hospital for Sick Children
Martin Hrabé de Angelis
Martin Hrabé de Angelis Technical University of Munich
Rajesh V. Thakker
Rajesh V. Thakker University of Oxford
Helen Parkinson
Helen Parkinson European Bioinformatics Institute
Wolfgang Wurst
Wolfgang Wurst German Center for Neurodegenerative Diseases
Kevin C K Lloyd
Kevin C K Lloyd University of California, Davis
Yann Herault
Yann Herault Institute of Genetics and Molecular and Cellular Biology
Matthew A. Brown
Matthew A. Brown Guy's and St Thomas' NHS Foundation Trust

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