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Genetics
UK
2024
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Genetics and Molecular Biology
UK
2024

D-Index & Metrics

Genetics

D-Index
116
Citations
75042
World Ranking
436
National Ranking
71

Medicine

D-Index
123
Citations
83071
World Ranking
3272
National Ranking
332

Research.com Recognitions

  • 2024 - Research.com Genetics in United Kingdom Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in United Kingdom Leader Award
  • 2023 - Research.com Genetics in United Kingdom Leader Award

Overview

Matthew A. Brown is affiliated with Guy's and St Thomas' NHS Foundation Trust in the United Kingdom. Their research primarily spans the fields of Medicine as well as Biochemistry, Genetics and Molecular Biology, reflecting an interdisciplinary approach to complex biomedical issues.

Their work includes extensive contributions to subfields such as Rheumatology, Genetics, Immunology, Molecular Biology, and Pathology and Forensic Medicine. These areas underline a focus on both clinical and molecular investigations related to immune-mediated conditions and genetic diseases.

Major topics covered in their research encompass:

  • Spondyloarthritis Studies and Treatments
  • Psoriasis: Treatment and Pathogenesis
  • Cancer Genomics and Diagnostics
  • Genomics and Rare Diseases
  • Rheumatoid Arthritis Research and Therapies
  • Autoimmune and Inflammatory Disorders Research
  • Genetic factors in colorectal cancer

Matthew A. Brown has published in a number of prominent journals and venues including bioRxiv (Cold Spring Harbor Laboratory), arXiv (Cornell University), Annals of the Rheumatic Diseases, Nature Communications, and Nature. These venues indicate contributions to both preprint repositories and peer-reviewed journals, balancing rapid dissemination and rigorous review.

Frequent co-authors collaborating with Matthew A. Brown include Marta Bleda, Zhixiu Li, Mark J. Caulfield, D. Perez-Gil, and Richard H. Scott, reflecting ongoing partnerships that likely support diverse aspects of their research program.

Recent significant publications include:

  • Whole-genome sequencing of patients with rare diseases in a national health system, 2020, Nature
  • Ankylosing spondylitis: an autoimmune or autoinflammatory disease?, 2021, Nature Reviews Rheumatology
  • Substitution mutational signatures in whole-genome-sequenced cancers in the UK population, 2022, Science
  • Whole-genome sequencing of a sporadic primary immunodeficiency cohort, 2020, Nature
  • Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19, 2021, New England Journal of Medicine

The breadth of publication venues and the scope of topics indicate a multidisciplinary research agenda touching on genomics, immunology, and clinical medicine. The inclusion of cutting-edge genomics and immunological studies reflects an engagement with contemporary challenges in medical research, including autoimmune diseases and infectious disease therapeutics.

Best Publications

  • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

    Paul R. Burton;David G. Clayton;Lon R. Cardon;Nick Craddock

  • 10 Years of GWAS Discovery: Biology, Function, and Translation

    Peter M. Visscher;Naomi R. Wray;Qian Zhang;Pamela Sklar

  • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

    Stephen Sawcer;Garrett Hellenthal;Matti Pirinen;Chris C. A. Spencer

  • Five years of GWAS discovery

    Peter M. Visscher;Peter M. Visscher;Matthew A. Brown;Mark I. McCarthy;Mark I. McCarthy;Jian Yang

  • Genome-wide association study identifies five new schizophrenia loci

    Stephan Ripke;Alan R. Sanders;Kenneth S. Kendler;Douglas F. Levinson

  • Genetics of rheumatoid arthritis contributes to biology and drug discovery

    Yukinori Okada;Yukinori Okada;Di Wu;Di Wu;Di Wu;Gosia Trynka;Gosia Trynka;Towfique Raj;Towfique Raj

  • Genome-wide association study identifies eight loci associated with blood pressure

    Christopher Newton-Cheh;Christopher Newton-Cheh;Toby Johnson;Toby Johnson;Vesela Gateva;Martin D. Tobin

  • Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

    Paul R Burton;David G Clayton;Lon R Cardon;Nick Craddock

  • Correction: Corrigendum: Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis

    John Bowes;Ashley Budu-Aggrey;Ulrike Huffmeier;Steffen Uebe

  • Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

    Karol Estrada;Unnur Styrkarsdottir;Evangelos Evangelou;Yi-Hsiang Hsu

  • A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva

    Eileen M Shore;Meiqi Xu;George J Feldman;David A Fenstermacher

  • Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

    Lam C. Tsoi;Sarah L. Spain;Sarah L. Spain;Jo Knight;Eva Ellinghaus;Eva Ellinghaus

  • A Genome-Wide Association Study Identifies New Psoriasis Susceptibility Loci and an Interaction Between HLA-C and ERAP1

    Amy Strange;Francesca Capon;Chris C A Spencer

  • Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

    D M Evans;Spencer Cca.;J J Pointon;Z Su

  • Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

    Nick Craddock;Matthew E. Hurles;Niall Cardin;Richard D. Pearson

  • Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci.

    A Cortes;J Hadler;J P Pointon

  • Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

    David Ellinghaus;Luke Jostins;Sarah L. Spain;Adrian Cortes

  • Susceptibility to ankylosing spondylitis in twins the role of genes, HLA, and the environment

    M A Brown;L G Kennedy;A J MacGregor;C Darke

  • A genome-wide asociation study identifies new psoriasis susceptibility loci and an interaction betwEn HLA-C and ERAP1

    A. Strange;F. Capon;C. C. A. Spencer;J. Knight

  • A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva

    E. M. Shore;M. Xu;G. J. Feldman;D. A. Fenstermacher

Frequent Co-Authors

Emma L. Duncan
Emma L. Duncan University of Queensland
David Evans
David Evans University of Bristol
John D. Reveille
John D. Reveille The University of Texas Health Science Center at Houston
Philip C. Robinson
Philip C. Robinson University of Queensland
Michael H. Weisman
Michael H. Weisman Cedars-Sinai Medical Center
Peter Donnelly
Peter Donnelly University of Oxford
Alex W. Hewitt
Alex W. Hewitt University of Tasmania
Sarah Hunt
Sarah Hunt European Bioinformatics Institute
Juan P. Casas
Juan P. Casas Boston University
Jenefer M. Blackwell
Jenefer M. Blackwell Telethon Kids Institute

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