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Neuroscience

D-Index
42
Citations
6113
World Ranking
7702
National Ranking
3306

Overview

Mark Estacion is affiliated with Yale University in the United States. Their research primarily focuses on the fields of Neuroscience, Biochemistry, Genetics and Molecular Biology, and Medicine. Within these broad areas, their subfields of study include Molecular Biology, Cellular and Molecular Neuroscience, Physiology, Cardiology and Cardiovascular Medicine, and Pharmacology.

Their work extensively covers topics such as ion channel regulation and function, pain mechanisms and treatments, neuroscience and neuropharmacology research, neuroscience and neural engineering, cardiac electrophysiology and arrhythmias, cannabis and cannabinoid research, and neural dynamics and brain function.

Recent publications by Mark Estacion include the following:

  • Differential effect of lacosamide on Nav1.7 variants from responsive and non-responsive patients with small fibre neuropathy, 2020, Brain
  • Contributions of NaV1.8 and NaV1.9 to excitability in human induced pluripotent stem-cell derived somatosensory neurons, 2021, Scientific Reports
  • Inhibition of sodium conductance by cannabigerol contributes to a reduction of dorsal root ganglion neuron excitability, 2022, British Journal of Pharmacology
  • KCNQ variants and pain modulation: a missense variant in Kv7.3 contributes to pain resilience, 2021, Brain Communications
  • Depolarizing NaV and Hyperpolarizing KV Channels Are Co-Trafficked in Sensory Neurons, 2022, Journal of Neuroscience

Mark Estacion frequently collaborates with notable researchers including:

  • Stephen G. Waxman
  • Sulayman D. Dib-Hajj
  • Peng Zhao
  • Mohammad-Reza Ghovanloo
  • Fadia B. Dib-Hajj

Key publication venues for their work include Frontiers in Pharmacology, bioRxiv (Cold Spring Harbor Laboratory), Biophysical Journal, Brain, and Scientific Reports.

Best Publications

  • Gain of function NaV1.7 mutations in idiopathic small fiber neuropathy

    Catharina G. Faber;Janneke G.J. Hoeijmakers;Hye Sook Ahn;Hye Sook Ahn;Xiaoyang Cheng;Xiaoyang Cheng

  • Gain-of-function mutations in sodium channel Na(v)1.9 in painful neuropathy.

    Jianying Huang;Chongyang Han;Mark Estacion;Dymtro Vasylyev

  • NaV1.7 Gain-of-Function Mutations as a Continuum: A1632E Displays Physiological Changes Associated with Erythromelalgia and Paroxysmal Extreme Pain Disorder Mutations and Produces Symptoms of Both Disorders

    M. Estacion;S. D. Dib-Hajj;P. J. Benke;Rene H. M. te Morsche

  • P2X7 Receptor-Dependent Blebbing and the Activation of Rho-Effector Kinases, Caspases, and IL-1β Release

    Philip A. Verhoef;Mark Estacion;William Schilling;William Schilling;George R. Dubyak

  • Safety and efficacy of a Nav1.7 selective sodium channel blocker in patients with trigeminal neuralgia: a double-blind, placebo-controlled, randomised withdrawal phase 2a trial

    Joanna M Zakrzewska;Joanne Palmer;Valerie Morisset;Gerard Mp Giblin

  • Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release

    Aristos J. Alexandrou;Adam R. Brown;Mark L. Chapman;Mark Estacion

  • Regulation of Drosophila transient receptor potential-like (TrpL) channels by phospholipase C-dependent mechanisms

    Mark Estacion;William G. Sinkins;William P. Schilling

  • Identification and localization of TRPC channels in the rat kidney.

    Monu Goel;William G. Sinkins;Cheng Di Zuo;Mark Estacion

  • A novel Nav1.7 mutation producing carbamazepine-responsive erythromelalgia.

    Tanya Z. Fischer;Elaine S. Gilmore;Elaine S. Gilmore;Mark Estacion;Mark Estacion;Emmanuella Eastman;Emmanuella Eastman

  • Ca2+ influx via T-type channels modulates PDGF-induced replication of mouse fibroblasts.

    Zheng Wang;M. Estacion;L. J. Mordan

  • Paroxysmal extreme pain disorder M1627K mutation in human Nav1.7 renders DRG neurons hyperexcitable.

    Sulayman D Dib-Hajj;Mark Estacion;Brian W Jarecki;Lynda Tyrrell

  • Human TRPC6 expressed in HEK 293 cells forms non-selective cation channels with limited Ca2+ permeability

    Mark Estacion;William G. Sinkins;Stephen W. Jones;Milana A. B. Applegate

  • Association of Immunophilins with Mammalian TRPC Channels

    William G. Sinkins;Monu Goel;Mark Estacion;William P. Schilling

  • Functional expression of TrpC1: a human homologue of the Drosophila Trp channel

    William G. Sinkins;Mark Estacion;William P. Schilling

  • Voltage-clamp and current-clamp recordings from mammalian DRG neurons

    Theodore R Cummins;Anthony M Rush;Mark Estacion;Mark Estacion;Sulayman D Dib-Hajj;Sulayman D Dib-Hajj

  • Characterization of a de novo SCN8A mutation in a patient with epileptic encephalopathy

    Carolien G.F. de Kovel;Miriam H. Meisler;Eva H. Brilstra;Frederique M.C. van Berkestijn

  • A sodium channel gene SCN9A polymorphism that increases nociceptor excitability

    Mark Estacion;T. Patrick Harty;T. Patrick Harty;Jin-Sung Choi;Jin-Sung Choi;Lynda Tyrrell;Lynda Tyrrell

  • Intra- and Interfamily Phenotypic Diversity in Pain Syndromes Associated with a Gain-of-Function Variant of NaV1.7:

    Mark Estacion;Chongyang Han;Jin Sung Choi;Jin Sung Choi;Janneke G J Hoeijmakers

  • Activation of human TRPC6 channels by receptor stimulation.

    Mark Estacion;Su Li;William G. Sinkins;Martin Gosling

  • Human Nav1.8: enhanced persistent and ramp currents contribute to distinct firing properties of human DRG neurons

    Chongyang Han;Mark Estacion;Jianying Huang;Dymtro Vasylyev

  • A sodium channel mutation linked to epilepsy increases ramp and persistent current of Nav1.3 and induces hyperexcitability in hippocampal neurons

    Mark Estacion;Andreas Gasser;Andreas Gasser;Sulayman D. Dib-Hajj;Sulayman D. Dib-Hajj;Stephen G. Waxman;Stephen G. Waxman

  • Structural modelling and mutant cycle analysis predict pharmacoresponsiveness of a Na(V)1.7 mutant channel.

    Yang Yang;Sulayman D. Dib-Hajj;Jian Zhang;Yang Zhang

  • NaV1.7 Gain-of-function Mutations As A Continuum: A1632E Displays Physiological Changes Associated With Erythromelalgia And Paroxysmal Extreme Pain Disorder Mutations And Produces Symptoms Of Both Disorders

    Mark Estacion;Sulayman D. Dib-Hajj;Paul J. Benke;R.H.M. te Morsche

Frequent Co-Authors

Stephen G. Waxman
Stephen G. Waxman Yale University
Sulayman D. Dib-Hajj
Sulayman D. Dib-Hajj Yale University
Giuseppe Lauria
Giuseppe Lauria University of Milan
Joel A. Black
Joel A. Black Yale University
Theodore R. Cummins
Theodore R. Cummins Indiana University – Purdue University Indianapolis
Clifford J. Woolf
Clifford J. Woolf Boston Children's Hospital
Miriam H. Meisler
Miriam H. Meisler University of Michigan–Ann Arbor
Michael F. Hammer
Michael F. Hammer University of Arizona
Bobby P.C. Koeleman
Bobby P.C. Koeleman Utrecht University
Hubert J.M. Smeets
Hubert J.M. Smeets Maastricht University

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