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Chemistry

D-Index
71
Citations
17035
World Ranking
5594
National Ranking
1727

Biology and Biochemistry

D-Index
76
Citations
21246
World Ranking
5037
National Ranking
2417

Research.com Recognitions

  • 1998 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Rachel E. Klevit is affiliated with the University of Washington in the United States. Their research primarily spans the field of Biochemistry, Genetics, and Molecular Biology, with a total of 92 publications in this domain. The work extends into several subfields, including Molecular Biology, Spectroscopy, Cell Biology, Genetics, and Endocrinology.

The main research topics tackled by Klevit encompass:

  • Heat shock proteins research
  • DNA Repair Mechanisms
  • RNA and protein synthesis mechanisms
  • Ubiquitin and proteasome pathways
  • Protein Structure and Dynamics
  • Connexins and lens biology
  • Genomics and Chromatin Dynamics

Among the recent papers published by Klevit are:

  • BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1, 2021, Nature Structural & Molecular Biology
  • Mediator subunit Med15 dictates the conserved "fuzzy" binding mechanism of yeast transcription activators Gal4 and Gcn4, 2021, Nature Communications
  • The BRCA1/BARD1 ubiquitin ligase and its substrates, 2021, Biochemical Journal
  • Release of a disordered domain enhances HspB1 chaperone activity toward tau, 2020, Proceedings of the National Academy of Sciences
  • Who with whom: functional coordination of E2 enzymes by RING E3 ligases during poly-ubiquitylation, 2020, The EMBO Journal

Klevit has frequently collaborated with other researchers, including:
Samuel R Witus, Lisa M. Tuttle, Maria K. Janowska, Miklós Guttman, and Peter S. Brzović.

The scientist's work has been published predominantly in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Biological Chemistry
  • Nature Communications
  • Proceedings of the National Academy of Sciences
  • eLife

Rachel E. Klevit was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 1998.

Best Publications

  • UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids

    Dawn M. Wenzel;Alexei Lissounov;Peter S. Brzovic;Rachel E. Klevit

  • RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination.

    Meredith B. Metzger;Jonathan N. Pruneda;Rachel E. Klevit;Allan M. Weissman

  • Mutant Adenosine Deaminase 2 in a Polyarteritis Nodosa Vasculopathy

    Paulina Navon Elkan;Sarah B. Pierce;Reeval Segel;Reeval Segel;Tom Walsh

  • Recognition of Antimicrobial Peptides by a Bacterial Sensor Kinase

    Martin W. Bader;Sarah Sanowar;Margaret E. Daley;Anna R. Schneider

  • Structure of a BRCA1-BARD1 heterodimeric RING-RING complex.

    Peter S. Brzovic;Ponni Rajagopal;David W. Hoyt;Mary Claire King

  • Proof of principle for epitope-focused vaccine design

    Bruno Emanuel F. Sousa Correia;John T. Bates;Rebecca J. Loomis;Gretchen Baneyx

  • E2 enzymes: more than just middle men.

    Mikaela D Stewart;Tobias Ritterhoff;Rachel E Klevit;Peter S Brzovic

  • Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex.

    Peter S. Brzovic;Jennifer R. Keeffe;Hiroyuki Nishikawa;Keiko Miyamoto

  • E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages.

    Devin E Christensen;Peter S Brzovic;Rachel E Klevit

  • Zinc-dependent structure of a single-finger domain of yeast ADR1.

    Grace Párraga;Suzanna J. Horvath;Arri Eisen;Wayne E. Taylor

  • One size does not fit all: The oligomeric states of αB crystallin

    Scott P. Delbecq;Rachel E. Klevit

  • A UbcH5/Ubiquitin Noncovalent Complex Is Required for Processive BRCA1-Directed Ubiquitination

    Peter S. Brzovic;Alexei Lissounov;Devin E. Christensen;David W. Hoyt

  • Structure of an E3:E2~Ub complex reveals an allosteric mechanism shared among RING/U-box ligases

    Jonathan N. Pruneda;Peter J. Littlefield;Sarah E. Soss;Kyle A. Nordquist

  • Activation of the Bacterial Sensor Kinase PhoQ by Acidic pH

    Lynne R. Prost;Margaret E. Daley;Valerie Le Sage;Martin W. Bader

  • Mutations in mitochondrial histidyl tRNA synthetase HARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault syndrome

    Sarah B. Pierce;Karen M. Chisholm;Eric D. Lynch;Ming K. Lee

  • Mass Spectrometric and Mutational Analyses Reveal Lys-6-linked Polyubiquitin Chains Catalyzed by BRCA1-BARD1 Ubiquitin Ligase

    Hiroyuki Nishikawa;Seido Ooka;Ko Sato;Kei Arima

  • Solid-state NMR and SAXS studies provide a structural basis for the activation of αB-crystallin oligomers

    Stefan Jehle;Ponni Rajagopal;Benjamin Bardiaux;Stefan Markovic;Stefan Markovic

  • Mutations in the DBP-Deficiency Protein HSD17B4 Cause Ovarian Dysgenesis, Hearing Loss, and Ataxia of Perrault Syndrome

    Sarah B. Pierce;Tom Walsh;Karen M. Chisholm;Ming K. Lee

  • Structural Basis for Mechanical Force Regulation of the Adhesin FimH via Finger Trap-like β Sheet Twisting

    Isolde Le Trong;Pavel Aprikian;Brian A. Kidd;Manu Forero-Shelton;Manu Forero-Shelton

  • Pharmacological chaperone for α-crystallin partially restores transparency in cataract models

    Leah N. Makley;Kathryn A. McMenimen;Brian T. DeVree;Joshua W. Goldman

  • E2s: structurally economical and functionally replete.

    Dawn M. Wenzel;Kate E. Stoll;Rachel E. Klevit

Frequent Co-Authors

Mary Claire King
Mary Claire King University of Washington
Tom Walsh
Tom Walsh University of Washington
Samuel I. Miller
Samuel I. Miller University of Washington
David Baker
David Baker University of Washington
Ming K. Lee
Ming K. Lee University of Washington
Steven Hahn
Steven Hahn Fred Hutchinson Cancer Research Center
Hartmut Oschkinat
Hartmut Oschkinat Freie Universität Berlin
Ronald E. Stenkamp
Ronald E. Stenkamp University of Washington
Joseph A. Beavo
Joseph A. Beavo University of Washington
Bennett M. Shapiro
Bennett M. Shapiro VBL Therapeutics

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