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Molecular Biology

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76
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18729
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Overview

Steven Hahn is affiliated with the Fred Hutchinson Cancer Research Center in the United States. Their research primarily focuses on the field of Biochemistry, Genetics, and Molecular Biology, with a specialization in Molecular Biology and Biophysics. Hahn's work encompasses several topics including Genomics and Chromatin Dynamics, RNA Research and Splicing, Fungal and yeast genetics research, RNA and protein synthesis mechanisms, Protein Degradation and Inhibitors, Ubiquitin and proteasome pathways, and Single-cell and spatial transcriptomics.

The scientist has contributed to a number of publications, appearing repeatedly in venues such as bioRxiv (Cold Spring Harbor Laboratory), Molecular Cell, eLife, Cell Reports, and Nature Communications. Their frequent coauthors include Linda Warfield, Rafał Donczew, Lakshmi Mahendrawada, Jeremy A. Schofield, and Ariel Erijman.

Selected recent papers by Steven Hahn include:

  • A High-Throughput Screen for Transcription Activation Domains Reveals Their Sequence Features and Permits Prediction by Deep Learning, 2020, Molecular Cell
  • Two roles for the yeast transcription coactivator SAGA and a set of genes redundantly regulated by TFIID and SAGA, 2020, eLife
  • Mediator subunit Med15 dictates the conserved "fuzzy" binding mechanism of yeast transcription activators Gal4 and Gcn4, 2021, Nature Communications
  • Low overlap of transcription factor DNA binding and regulatory targets, 2025, Nature
  • BET family members Bdf1/2 modulate global transcription initiation and elongation in Saccharomyces cerevisiae, 2021, eLife

Among the frequent publication venues where Hahn's work appears are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Cell
  • eLife
  • Cell Reports
  • Nature Communications

The scientist's most frequent collaborators include:

  • Linda Warfield
  • Rafał Donczew
  • Lakshmi Mahendrawada
  • Jeremy A. Schofield
  • Ariel Erijman

Steven Hahn's research interests cover various aspects of molecular biology, with a particular emphasis on transcription mechanisms and chromatin dynamics in yeast and other model organisms. Their publications indicate active engagement in understanding transcription activation domains, transcription coactivators like SAGA and TFIID, as well as global transcription regulation mechanisms.

Best Publications

  • Crystal structure of a yeast TBP/TATA-box complex.

    Youngchang Kim;James. H. Geiger;Steven Hahn;Paul B. Sigler

  • Five intermediate complexes in transcription initiation by RNA polymerase II

    Stephen Buratowski;Steven Hahn;Leonard Guarente;Phillip A. Sharp

  • Structure and mechanism of the RNA polymerase II transcription machinery

    Steven Hahn

  • A transcription reinitiation intermediate that is stabilized by activator.

    Natalya Yudkovsky;Jeffrey A. Ranish;Jeffrey A. Ranish;Steven Hahn;Steven Hahn

  • Function of a yeast TATA element-binding protein in a mammalian transcription system

    Stephen Buratowski;Steven Hahn;Phillip A. Sharp;Leonard Guarente

  • An operator at -280 base pairs that is required for repression of araBAD operon promoter: addition of DNA helical turns between the operator and promoter cyclically hinders repression

    Teresa M. Dunn;Steven Hahn;Sharon Ogden;Robert F. Schleif

  • Transcriptional Regulation in Saccharomyces cerevisiae: Transcription Factor Regulation and Function, Mechanisms of Initiation, and Roles of Activators and Coactivators

    Steven Hahn;Elton T. Young

  • Mot1, a global repressor of RNA polymerase II transcription, inhibits TBP binding to DNA by an ATP-dependent mechanism.

    D. T. Auble;K. E. Hansen;C. G. F. Mueller;W. S. Lane

  • Yeast TATA-binding protein TFIID binds to TATA elements with both consensus and nonconsensus DNA sequences

    Steven Hahn;Stephen Buratowski;Phillip A. Sharp;Leonard Guarente

  • Each of three "TATA elements" specifies a subset of the transcription initiation sites at the CYC-1 promoter of Saccharomyces cerevisiae.

    Steven Hahn;Eileen T. Hoar;Leonard Guarente

  • Isolation of the gene encoding the yeast TATA binding protein TFIID: A gene identical to the SPT15 suppressor of Ty element insertions

    Steven Hahn;Stephen Buratowski;Phillip A. Sharp;Leonard Guarente

  • Recruitment of the SWI/SNF chromatin remodeling complex by transcriptional activators

    Natalya Yudkovsky;Colin Logie;Steven Hahn;Craig L. Peterson

  • Yeast nuclear extract contains two major forms of RNA polymerase II mediator complexes.

    Ying Liu;Jeffrey A. Ranish;Ruedi Aebersold;Steven Hahn

  • The role of the TATA-binding protein in the assembly and function of the multisubunit yeast RNA polymerase III transcription factor, TFIIIB

    George A. Kassavetis;Claudio A.P. Joazeiro;Marina Pisano;E.Peter Geiduschek

  • Intermediates in formation and activity of the RNA polymerase II preinitiation complex: holoenzyme recruitment and a postrecruitment role for the TATA box and TFIIB.

    Jeffrey A. Ranish;Natalya Yudkovsky;Steven Hahn

  • A yeast and a human CCAAT-binding protein have heterologous subunits that are functionally interchangeable

    Lewis A. Chodosh;James Olesen;Steven Hahn;Albert S. Baldwin;Albert S. Baldwin

  • Yeast HAP2 and HAP3 activators both bind to the CYC1 upstream activation site, UAS2, in an interdependent manner.

    James Olesen;Steven Hahn;Leonard Guarente

  • Variants of the TATA-binding protein can distinguish subsets of RNA polymerase I, II, and III promoters.

    Michael C. Schultz;Ronald H. Reeder;Steven Hahn

  • Phosphorylation of the Transcription Elongation Factor Spt5 by Yeast Bur1 Kinase Stimulates Recruitment of the PAF Complex

    Ying Liu;Linda Warfield;Chao Zhang;Jie Luo

  • Transcriptional regulation. Meeting on regulatory mechanisms in eukaryotic transcription.

    Steven Hahn

Frequent Co-Authors

Jeffrey A. Ranish
Jeffrey A. Ranish University of Washington
Rachel E. Klevit
Rachel E. Klevit University of Washington
Stephen Buratowski
Stephen Buratowski Harvard University
Robert Schleif
Robert Schleif Johns Hopkins University
Dylan J. Taatjes
Dylan J. Taatjes University of Colorado Boulder
Johannes Söding
Johannes Söding Max Planck Society
William S. Lane
William S. Lane Harvard University

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