World's Best Scientists 2026 revealed!
Hiroyuki Mano

Hiroyuki Mano

D-Index & Metrics

Biology and Biochemistry

D-Index
87
Citations
37249
World Ranking
2776
National Ranking
173

Medicine

D-Index
87
Citations
37153
World Ranking
13450
National Ranking
399

Overview

Hiroyuki Mano is affiliated with the University of Tokyo in Japan and has focused their research primarily in the fields of Medicine, and Biochemistry, Genetics and Molecular Biology. Their work spans subfields including Molecular Biology, Oncology, Pulmonary and Respiratory Medicine, Cancer Research, and Pathology and Forensic Medicine.

The scientist's research topics concentrate on Cancer Genomics and Diagnostics, Cancer Immunotherapy and Biomarkers, Lung Cancer Treatments and Mutations, Sarcoma Diagnosis and Treatment, RNA modifications and cancer, Genetic factors in colorectal cancer, and Colorectal Cancer Treatments and Studies.

Recent significant papers authored or co-authored by Hiroyuki Mano include:

  • The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies, 2020, Nature Immunology
  • Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments, 2022, Cancer Cell
  • An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells, 2020, Immunity
  • C-CAT: The National Datacenter for Cancer Genomic Medicine in Japan, 2022, Cancer Discovery
  • Immune evasion through mitochondrial transfer in the tumour microenvironment, 2025, Nature

Hiroyuki Mano collaborates frequently with several researchers including Shinji Kohsaka, Toshihide Ueno, Masahito Kawazu, Shinya Kojima, and Masachika Ikegami. These collaborations reflect an extensive network in cancer-related research.

The scientist has published in multiple venues, with the most frequent being Cancer Science, Cancer Research, npj Precision Oncology, Nature, and Clinical Cancer Research. These publication sites correspond with the main and subfields of their research interest.

Best Publications

  • Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer

    Manabu Soda;Young Lim Choi;Munehiro Enomoto;Shuji Takada

  • RET, ROS1 and ALK fusions in lung cancer.

    Kengo Takeuchi;Manabu Soda;Yuki Togashi;Ritsuro Suzuki

  • EML4-ALK Mutations in Lung Cancer That Confer Resistance to ALK Inhibitors

    Young Lim Choi;Manabu Soda;Yoshihiro Yamashita;Toshihide Ueno

  • Oncogenic mutations of ALK kinase in neuroblastoma.

    Yuyan Chen;Junko Takita;Young Lim Choi;Motohiro Kato

  • KIF5B-ALK, a Novel Fusion Oncokinase Identified by an Immunohistochemistry-based Diagnostic System for ALK-positive Lung Cancer

    Kengo Takeuchi;Young Lim Choi;Yuki Togashi;Manabu Soda

  • A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner.

    R Sakai;A Iwamatsu;N Hirano;S Ogawa

  • The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies.

    Shogo Kumagai;Yosuke Togashi;Takahiro Kamada;Eri Sugiyama

  • A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer.

    King Pan Ng;Axel M Hillmer;Charles T H Chuah;Charles T H Chuah;Wen Chun Juan

  • A mouse model for EML4-ALK-positive lung cancer

    Manabu Soda;Shuji Takada;Kengo Takeuchi;Young Lim Choi

  • Multiplex Reverse Transcription-PCR Screening for EML4-ALK Fusion Transcripts

    Kengo Takeuchi;Young Lim Choi;Manabu Soda;Kentaro Inamura

  • Correction: Corrigendum: Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects

    Osamu Hashizume;Sakiko Ohnishi;Takayuki Mito;Akinori Shimizu

  • EML4-ALK Fusion Is Linked to Histological Characteristics in a Subset of Lung Cancers

    Kentaro Inamura;Kengo Takeuchi;Yuki Togashi;Kimie Nomura

  • Identification of Novel Isoforms of the EML4-ALK Transforming Gene in Non–Small Cell Lung Cancer

    Young Lim Choi;Kengo Takeuchi;Manabu Soda;Kentaro Inamura

  • EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset.

    Kentaro Inamura;Kengo Takeuchi;Yuki Togashi;Satoko Hatano

  • Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia.

    K. Mitani;S. Ogawa;T. Tanaka;H. Miyoshi

  • In vitro cytotoxic effects of a tyrosine kinase inhibitor STI571 in combination with commonly used antileukemic agents

    Yasuhiko Kano;Miyuki Akutsu;Saburo Tsunoda;Hiroyuki Mano

  • Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis

    Eugene Berezikov;Geert van Tetering;Mark Verheul;Jose van de Belt

  • MCPIP1 Ribonuclease Antagonizes Dicer and Terminates MicroRNA Biogenesis through Precursor MicroRNA Degradation

    Hiroshi I. Suzuki;Mayu Arase;Hironori Matsuyama;Young Lim Choi

  • Array-based genomic resequencing of human leukemia

    Y Yamashita;J Yuan;I Suetake;H Suzuki

  • Non-solid oncogenes in solid tumors : EML4-ALK fusion genes in lung cancer

    Hiroyuki Mano

Frequent Co-Authors

Kazuyuki Shimada
Kazuyuki Shimada Nagoya University
Uichi Ikeda
Uichi Ikeda Shinshu University
Hiroyuki Aburatani
Hiroyuki Aburatani University of Tokyo
Hisamaru Hirai
Hisamaru Hirai University of Tokyo
Keiya Ozawa
Keiya Ozawa Jichi Medical University
Yoshio Yazaki
Yoshio Yazaki University of Tokyo
Kohei Miyazono
Kohei Miyazono University of Tokyo
Seishi Ogawa
Seishi Ogawa Kyoto University
Yusuke Furukawa
Yusuke Furukawa Jichi Medical University
Fumimaro Takaku
Fumimaro Takaku University of Tokyo

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