2026 Mitsuhiko Ikura: Biology and Biochemistry Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Biology and Biochemistry	104	1237	1105	31	29	419	48176

Research.com Recognitions

2023 - Research.com Biology and Biochemistry in Canada Leader Award

Overview

Mitsuhiko Ikura is affiliated with the Princess Margaret Cancer Centre in Canada. Their research predominantly focuses on biochemistry, genetics, and molecular biology, with considerable contributions in the subfields of molecular biology, cell biology, materials chemistry, cancer research, and surgery.

The scientist's work covers key topics including:

Protein Kinase Regulation and GTPase Signaling
Cellular transport and secretion
Protein Tyrosine Phosphatases
Enzyme Structure and Function
Mitochondrial Function and Pathology
Cellular Mechanics and Interactions
Cancer, Hypoxia, and Metabolism

Mitsuhiko Ikura has published extensively, with a total of 89 works contributing to these fields. Their frequent publication venues include:

bioRxiv (Cold Spring Harbor Laboratory)
Angewandte Chemie
Angewandte Chemie International Edition
Proceedings of the National Academy of Sciences
Journal of Cell Science

Significant recent papers authored or co-authored by Mitsuhiko Ikura are:

Two Distinct Structures of Membrane-Associated Homodimers of GTP- and GDP-Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement, 2020, Angewandte Chemie International Edition
Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane, 2020, Proceedings of the National Academy of Sciences
The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors, 2021, Nature Communications
Real-Time In-Cell NMR Reveals the Intracellular Modulation of GTP-Bound Levels of RAS, 2020, Cell Reports
Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization, 2021, Chemical Science

Frequent collaborators in their research include:

Christopher B. Marshall
Geneviève M. C. Gasmi-Seabrook
Teklab Gebregiworgis
Masahiro Enomoto
Michael Ohh

Best Publications

Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin

Atsushi Miyawaki;Juan Llopis;Roger Heim;J. Michael McCaffery

4157
Citations
Rapid recording of 2D NMR spectra without phase cycling. Application to the study of hydrogen exchange in proteins

Dominique Marion;Mitsuhiko Ikura;Rolf Tschudin;Ad Bax

2041
Citations
Solution structure of a calmodulin-target peptide complex by multidimensional NMR.

M. Ikura;G.M. Clore;A.M. Gronenborn;Guang Zhu;Guang Zhu

1588
Citations
Three-dimensional triple-resonance NMR Spectroscopy of isotopically enriched proteins

Lewis E Kay;Mitsuhiko Ikura;Rolf Tschudin;Ad Bax

1411
Citations
A novel approach for sequential assignment of proton, carbon-13, and nitrogen-15 spectra of larger proteins: heteronuclear triple-resonance three-dimensional NMR spectroscopy. Application to calmodulin

Mitsuhiko Ikura;Lewis E. Kay;Ad Bax

1228
Citations
Backbone dynamics of calmodulin studied by 15N relaxation using inverse detected two-dimensional NMR spectroscopy: the central helix is flexible.

Gaetano Barbato;Mitsuhiko Ikura;Lewis E. Kay;Richard W. Pastor

1201
Citations
Molecular and structural basis of target recognition by calmodulin.

Anna Crivici;Mitsuhiko Ikura

954
Citations
Calcium-induced conformational transition revealed by the solution structure of apo calmodulin.

Mingjie Zhang;Toshiyuki Tanaka;Mitsuhiko Ikura

905
Citations
Structural basis of calcium-induced E-cadherin rigidification and dimerization

Bhushan Nagar;Michael Overduin;Michael Overduin;Mitsuhiko Ikura;Mitsuhiko Ikura;James M. Rini

885
Citations
Calmodulin in Action: Diversity in Target Recognition and Activation Mechanisms

Klaus P. Hoeflich;Mitsuhiko Ikura

854
Citations
Calcium binding and conformational response in EF-hand proteins

Mitsuhiko Ikura

846
Citations
Comparison of different modes of two-dimensional reverse-correlation NMR for the study of proteins

Ad Bax;Mitsuhiko Ikura;Lewis E Kay;Dennis A Torchia

739
Citations
MazF cleaves cellular mRNAs specifically at ACA to block protein synthesis in Escherichia coli.

Yonglong Zhang;Junjie Zhang;Klaus P Hoeflich;Mitsuhiko Ikura

677
Citations
Calmodulin Target Database

Kyoko L. Yap;Justin Kim;Kevin Truong;Marc Sherman

665
Citations
Cadherins in embryonic and neural morphogenesis

Ulrich Tepass;Kevin Truong;Dorothea Godt;Mitsuhiko Ikura

637
Citations
A Novel Approach for Sequential Assignment of 1H, 13C, and 15N Spectra of Larger Proteins: Heteronuclear Triple-Resonance Three-Dimensional NMR Spectroscopy. Application to Calmodulin

Mitsuhiko Ikura;Lewis E. Kay;Ad Bax

623
Citations
Improved solvent suppression in one-and two-dimensional NMR spectra by convolution of time-domain data

Dominique Marion;Mitsuhiko Ikura;Ad Bax

578
Citations
Molecular mechanics of calcium–myristoyl switches

James B. Ames;Rieko Ishima;Toshiyuki Tanaka;Jeffrey I. Gordon

561
Citations
Solution structure of the epithelial cadherin domain responsible for selective cell adhesion.

Michael Overduin;Timothy S. Harvey;Stefan Bagby;Kit I. Tong

552
Citations
The use of FRET imaging microscopy to detect protein-protein interactions and protein conformational changes in vivo.

Kevin Truong;Mitsuhiko Ikura

530
Citations