World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
51
Citations
18013
World Ranking
16934
National Ranking
598

Overview

Vuk Stambolic is affiliated with the University of Toronto in Canada and has contributed extensively to fields related to biochemistry, genetics, molecular biology, and medicine. Their research output includes a significant number of publications, with a strong focus on molecular biology, oncology, and cancer research subfields.

The main fields of study covered in their work include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these fields, their specific subfields of study are:

  • Molecular Biology
  • Oncology
  • Biophysics
  • Cancer Research
  • Pulmonary and Respiratory Medicine

Vuk Stambolic's research centers around several topics, notably those intersecting cancer and metabolic diseases. The main topics addressed in their publications are:

  • Metabolism, Diabetes, and Cancer
  • Cancer Risks and Factors
  • Cancer-related Molecular Pathways
  • PI3K/AKT/mTOR signaling in cancer
  • Advanced Breast Cancer Therapies
  • Advanced Fluorescence Microscopy Techniques
  • Growth Hormone and Insulin-like Growth Factors

The scientist has published in a variety of venues, frequently contributing to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Reports
  • npj Breast Cancer
  • Cancer Research
  • JAMA

Frequent collaborators in their work include Marguerite Ennis, Pamela J. Goodwin, Bingshu E. Chen, Karen A. Gelmon, and Timothy J. Whelan.

Some notable recent papers by Vuk Stambolic are:

  • Effect of Metformin vs Placebo on Invasive Disease-Free Survival in Patients With Breast Cancer, 2022, JAMA
  • Senescence, Necrosis, and Apoptosis Govern Circulating Cell-free DNA Release Kinetics, 2020, Cell Reports
  • Machine learning-enabled cancer diagnostics with widefield polarimetric second-harmonic generation microscopy, 2022, Scientific Reports
  • The PTEN and ATM axis controls the G1/S cell cycle checkpoint and tumorigenesis in HER2-positive breast cancer, 2021, Cell Death and Differentiation
  • The Effect of Metformin vs Placebo on Sex Hormones in Canadian Cancer Trials Group MA.32, 2020, JNCI Journal of the National Cancer Institute

Best Publications

  • Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

    Vuk Stambolic;Vuk Stambolic;Akira Suzuki;Akira Suzuki;José Luis de la Pompa;José Luis de la Pompa

  • Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cells

    Vuk Stambolic;Laurent Ruel;James R. Woodgett

  • Regulation of PTEN transcription by p53.

    V. Stambolic;D. MacPherson;D. Sas;Y. Lin

  • High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

    Akira Suzuki;José Luis de la Pompa;Vuk Stambolic;Andrew J. Elia

  • Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease.

    Stéphanie A. Backman;Vuk Stambolic;Akira Suzuki;Jillian Haight

  • Understanding the benefit of metformin use in cancer treatment

    Ryan J O Dowling;Pamela J Goodwin;Vuk Stambolic

  • High Incidence of Breast and Endometrial Neoplasia Resembling Human Cowden Syndrome in pten+/− Mice

    Vuk Stambolic;Ming-Sound Tsao;David Macpherson;Akira Suzuki

  • Metformin in cancer: translational challenges

    Ryan J O Dowling;Saroj Niraula;Vuk Stambolic;Pamela J Goodwin

  • Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress

    C. Bassi;J. Ho;T. Srikumar;Rjo J. O. Dowling

  • Restricted Accumulation of Phosphatidylinositol 3-Kinase Products in a Plasmalemmal Subdomain during Fcγ Receptor-Mediated Phagocytosis

    John G. Marshall;James W. Booth;Vuk Stambolic;Tak Mak

  • Metformin in Breast Cancer: Time for Action

    Pamela J. Goodwin;Jennifer A. Ligibel;Vuk Stambolic

  • Negative regulation of myofibroblast differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on chromosome 10).

    Eric S. White;Rachelle G. Atrasz;Biao Hu;Sem H. Phan

  • The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila.

    Sam E Scanga;Laurent Ruel;Richard C Binari;Brian Snow

  • The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization

    Fatemeh Fouladkou;Tamara Landry;Hiroshi Kawabe;Antje Neeb

  • Functional distinctions of protein kinase B/Akt isoforms defined by their influence on cell migration.

    Vuk Stambolic;James R. Woodgett

  • Localization of Rheb to the endomembrane is critical for its signaling function

    Claudia Buerger;Ben DeVries;Vuk Stambolic

  • Evaluation of metformin in early breast cancer: a modification of the traditional paradigm for clinical testing of anti-cancer agents

    Pamela J. Goodwin;Vuk Stambolic;Julie Lemieux;Bingshu E. Chen

  • Impact of the Obesity Epidemic on Cancer

    Pamela J. Goodwin;Vuk Stambolic

  • Genetic analysis of protein kinase B (AKT) in Drosophila

    Brian E. Staveley;Laurent Ruel;Jing Jin;Vuk Stambolic

  • Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten

    Stéphanie A. Backman;Danny Ghazarian;Kelvin So;Otto Sanchez

Frequent Co-Authors

Pamela J. Goodwin
Pamela J. Goodwin University of Toronto
Tak W. Mak
Tak W. Mak Princess Margaret Cancer Centre
Mitsuhiko Ikura
Mitsuhiko Ikura Princess Margaret Cancer Centre
Tak W. Mak
Tak W. Mak Princess Margaret Cancer Centre
Timothy J. Whelan
Timothy J. Whelan McMaster University
Dawn L. Hershman
Dawn L. Hershman Columbia University
Karen A. Gelmon
Karen A. Gelmon University of British Columbia
Ingrid A. Mayer
Ingrid A. Mayer Vanderbilt University Medical Center
James R. Woodgett
James R. Woodgett Lunenfeld-Tanenbaum Research Institute
Kathleen I. Pritchard
Kathleen I. Pritchard University of Toronto

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