World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
78
Citations
31063
World Ranking
4460
National Ranking
294

Overview

Takehiko Sasaki is affiliated with Tokyo Medical and Dental University in Japan. Their research spans multiple fields, primarily focusing on biochemistry, genetics, molecular biology, and medicine. Within these areas, key subfields of study include molecular biology, cell biology, genetics, neurology, and clinical psychology.

The scientist's work encompasses several main topics, such as cellular transport and secretion, genomic variations and chromosomal abnormalities, Hippo pathway signaling and YAP/TAZ, mental health treatment and access, child and adolescent psychosocial and emotional development, genetics and neurodevelopmental disorders, and metabolomics and mass spectrometry studies.

Recent publications by Takehiko Sasaki include:

  • PI4P/PS countertransport by ORP10 at ER-endosome membrane contact sites regulates endosome fission, 2021, The Journal of Cell Biology
  • A mass spectrometric method for in-depth profiling of phosphoinositide regioisomers and their disease-associated regulation, 2022, Nature Communications
  • Cross-Disorder Analysis of Genic and Regulatory Copy Number Variations in Bipolar Disorder, Schizophrenia, and Autism Spectrum Disorder, 2022, Biological Psychiatry
  • Immersive 3-Dimensional Virtual Reality Modeling for Case-Specific Presurgical Discussions in Cerebrovascular Neurosurgery, 2020, Operative Neurosurgery
  • Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice, 2020, Cancer Science

These publications illustrate a focus on cellular and molecular mechanisms, disease-associated regulation, and applications of advanced technologies such as mass spectrometry and virtual reality modeling in biomedical contexts.

Takehiko Sasaki collaborates frequently with several researchers. Frequent coauthors include:

  • Junko Sasaki (19 joint publications)
  • Junya Hasegawa (9 joint publications)
  • Shin Morioka (9 joint publications)
  • Hiroki Nakanishi (8 joint publications)
  • Akira Suzuki (6 joint publications)

The scientist's work has appeared in various publication venues, with multiple papers published in:

  • Nature Communications (5 publications)
  • The Journal of Cell Biology (3 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (3 publications)
  • Biological Psychiatry (2 publications)
  • Cell Reports (2 publications)

Best Publications

  • Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

    Vuk Stambolic;Vuk Stambolic;Akira Suzuki;Akira Suzuki;José Luis de la Pompa;José Luis de la Pompa

  • Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

    Nicholas Joza;Nicholas Joza;Santos A. Susin;Eric Daugas;William L. Stanford

  • TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

    Mark A. Lomaga;Wen Chen Yeh;Ildiko Sarosi;Gordon S. Duncan

  • Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration

    Takehiko Sasaki;Junko Irie-Sasaki;Junko Irie-Sasaki;Russell G. Jones;Antonio J. Oliveira-dos-Santos

  • Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN

    Min Zhao;Bing Song;Jin Pu;Teiji Wada

  • High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

    Akira Suzuki;José Luis de la Pompa;Vuk Stambolic;Andrew J. Elia

  • The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development

    Jimmie E Fata;Young-Yun Kong;Young-Yun Kong;Ji Li;Takehiko Sasaki

  • Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

    Kurt Wolfgang Bachmaier;Connie Krawczyk;Ivona Kozieradzki;Young Yun Kong

  • Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas

    Yasuo Horie;Akira Suzuki;Ei Kataoka;Takehiko Sasaki

  • Regulation of Myocardial Contractility and Cell Size by Distinct PI3K-PTEN Signaling Pathways

    Michael A. Crackower;Gavin Y. Oudit;Ivona Kozieradzki;Ivona Kozieradzki;Renu Sarao;Renu Sarao

  • CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

    Junko Irie-Sasaki;Junko Irie-Sasaki;Takehiko Sasaki;Takehiko Sasaki;Wataru Matsumoto;Anne Opavsky

  • T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

    Akira Suzuki;Manae Tsukio Yamaguchi;Toshiaki Ohteki;Takehiko Sasaki

  • Endocrine functions of bone in mineral metabolism regulation

    L. Darryl Quarles

  • Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor.

    K.-D. Fischer;Y.-Y. Kong;H. Nishina;K. Tedford

  • The lipid phosphatase SHIP2 controls insulin sensitivity

    Serge Clément;Ulrike Krause;Florence Desmedt;Jean-François Tanti

  • SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival

    Qiurong Liu;Takehiko Sasaki;Ivona Kozieradzki;Andrew Wakeham

  • The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis

    Koichi Hamada;Takehiko Sasaki;Pandelakis A. Koni;Miyuki Natsui

  • CD45: new jobs for an old acquaintance.

    Josef M. Penninger;Junko Irie-Sasaki;Junko Irie-Sasaki;Takehiko Sasaki;Takehiko Sasaki;Antonio J. Oliveira-dos-Santos

  • Mammalian phosphoinositide kinases and phosphatases.

    Takehiko Sasaki;Shunsuke Takasuga;Junko Sasaki;Satoshi Kofuji

  • Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1

    Miki Nishio;Ken-ichi Watanabe;Junko Sasaki;Choji Taya

Frequent Co-Authors

Akira Suzuki
Akira Suzuki Kobe University
Josef M. Penninger
Josef M. Penninger University of British Columbia
Tak W. Mak
Tak W. Mak Princess Margaret Cancer Centre
Toru Nakano
Toru Nakano Osaka University
Tak W. Mak
Tak W. Mak Princess Margaret Cancer Centre
Hiroshi Nishina
Hiroshi Nishina Tokyo Medical and Dental University
Andrew Wakeham
Andrew Wakeham Princess Margaret Cancer Centre
Yasunori Kanaho
Yasunori Kanaho University of Tsukuba
Pamela S. Ohashi
Pamela S. Ohashi Princess Margaret Cancer Centre
Toshiaki Katada
Toshiaki Katada Musashino University

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