D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 71 Citations 29,367 131 World Ranking 2865 National Ranking 188

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Internal medicine

His scientific interests lie mostly in Cell biology, PTEN, Signal transduction, Cancer research and Protein kinase B. His studies in Protein tyrosine phosphatase and Phosphatidylinositol are all subfields of Cell biology research. He interconnects Molecular biology and Janus kinase in the investigation of issues within Protein tyrosine phosphatase.

In his study, which falls under the umbrella issue of PTEN, FLOX and Endocrinology is strongly linked to Tumor suppressor gene. His studies in Signal transduction integrate themes in fields like Autoimmunity, Kinase and Immunology. His work carried out in the field of Protein kinase B brings together such families of science as Mutation, Cancer, Lipid phosphatase activity and Mutant.

His most cited work include:

  • Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN (2101 citations)
  • Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN (2101 citations)
  • Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death (1167 citations)

What are the main themes of his work throughout his whole career to date?

Takehiko Sasaki mainly focuses on Cell biology, Cancer research, Phosphatidylinositol, PTEN and Kinase. The Cell biology study combines topics in areas such as Molecular biology and Biochemistry. His biological study spans a wide range of topics, including Pi, Cancer, Protein kinase B and PI3K/AKT/mTOR pathway.

His Protein kinase B research incorporates elements of Endocrinology and Internal medicine. His Phosphatidylinositol study combines topics from a wide range of disciplines, such as Prostate cancer and Pleckstrin homology domain. As a member of one scientific family, Takehiko Sasaki mostly works in the field of PTEN, focusing on Tumor suppressor gene and, on occasion, FLOX.

He most often published in these fields:

  • Cell biology (65.24%)
  • Cancer research (33.16%)
  • Phosphatidylinositol (30.48%)

What were the highlights of his more recent work (between 2015-2021)?

  • Cell biology (65.24%)
  • Cancer research (33.16%)
  • Phosphatidylinositol (30.48%)

In recent papers he was focusing on the following fields of study:

Cell biology, Cancer research, Phosphatidylinositol, PI3K/AKT/mTOR pathway and Kinase are his primary areas of study. His Cell biology study incorporates themes from Inflammation, Stimulation and Biochemistry. Takehiko Sasaki combines subjects such as Pi, Hippo signaling pathway and PTEN with his study of Cancer research.

His Phosphatidylinositol research focuses on Phosphate and how it connects with Renal cell carcinoma and Enzyme. His research in PI3K/AKT/mTOR pathway tackles topics such as Immunology which are related to areas like Candida albicans and In vivo. His studies deal with areas such as Protein kinase B, Hypoxanthine and Purine as well as Kinase.

Between 2015 and 2021, his most popular works were:

  • Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice (96 citations)
  • PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K (91 citations)
  • Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells. (53 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Internal medicine

Takehiko Sasaki mainly investigates Cancer research, Kinase, Protein kinase B, PI3K/AKT/mTOR pathway and Protein kinase A. As part of the same scientific family, he usually focuses on Cancer research, concentrating on Hippo signaling pathway and intersecting with Growth factor receptor, Cellular differentiation, Lung and Stem cell. His Kinase research includes elements of Cell cycle and Lung cancer.

His PI3K/AKT/mTOR pathway research is multidisciplinary, incorporating perspectives in Cell culture, Phosphatidylinositol, Hypoxanthine and Purine. Stromal cell, Cytokine, Signal transduction, Matrix metalloproteinase and Proinflammatory cytokine is closely connected to Downregulation and upregulation in his research, which is encompassed under the umbrella topic of Protein kinase A. The concepts of his AMPK study are interwoven with issues in Endocrinology and Internal medicine.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

Vuk Stambolic;Vuk Stambolic;Akira Suzuki;Akira Suzuki;José Luis de la Pompa;José Luis de la Pompa.
Cell (1998)

2953 Citations

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

Nicholas Joza;Nicholas Joza;Santos A. Susin;Eric Daugas;William L. Stanford.
Nature (2001)

1770 Citations

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

Mark A. Lomaga;Wen Chen Yeh;Ildiko Sarosi;Gordon S. Duncan.
Genes & Development (1999)

1453 Citations

Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration

Takehiko Sasaki;Junko Irie-Sasaki;Russell G. Jones;Antonio J. Oliveira-dos-Santos.
Science (2000)

1225 Citations

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

Akira Suzuki;José Luis de la Pompa;Vuk Stambolic;Andrew J. Elia.
Current Biology (1998)

936 Citations

Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN

Min Zhao;Bing Song;Jin Pu;Teiji Wada.
Nature (2006)

882 Citations

The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development.

Jimmie E Fata;Jimmie E Fata;Young-Yun Kong;Young-Yun Kong;Ji Li;Takehiko Sasaki.
Cell (2000)

837 Citations

Regulation of Myocardial Contractility and Cell Size by Distinct PI3K-PTEN Signaling Pathways

Michael A. Crackower;Gavin Y. Oudit;Ivona Kozieradzki;Ivona Kozieradzki;Renu Sarao;Renu Sarao.
Cell (2002)

731 Citations

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

Kurt Wolfgang Bachmaier;Connie Krawczyk;Ivona Kozieradzki;Young Yun Kong.
Nature (2000)

710 Citations

CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

Junko Irie-Sasaki;Junko Irie-Sasaki;Takehiko Sasaki;Takehiko Sasaki;Wataru Matsumoto;Anne Opavsky.
Nature (2001)

670 Citations

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