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8525
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Overview

Hiroshi Nishina is a researcher affiliated with Tokyo Medical and Dental University in Japan. Their academic work primarily focuses on biochemistry, genetics, and molecular biology, with additional contributions in medicine. Their research subfields include molecular biology, cell biology, oncology, biomedical engineering, and biochemistry.

Nishina's research topics cover a range of areas within molecular and cellular biology. Key topics include Hippo pathway signaling and YAP/TAZ, cancer-related gene regulation, cancer-related molecular pathways, pluripotent stem cells research, ubiquitin and proteasome pathways, 3D printing in biomedical research, and epigenetics and DNA methylation.

Recent publications by Nishina and their collaborators illustrate their research interests. These include:

  • "YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma," 2020, published in Science Advances
  • "Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice," 2020, published in Cancer Science
  • "Targeted DNA demethylation of the Fgf21 promoter by CRISPR/dCas9-mediated epigenome editing," 2020, published in Scientific Reports
  • "Physiological and pathological roles of the Hippo-YAP/TAZ signaling pathway in liver formation, homeostasis, and tumorigenesis," 2022, published in Cancer Science
  • "Puromycin-based purification of cells with high expression of the cytochrome P450 CYP3A4 gene from a patient with drug-induced liver injury (DILI)," 2022, published in Stem Cell Research & Therapy

Nishina frequently collaborates with other researchers including Akira Suzuki, Satoshi Kofuji, Junichi Maruyama, Kyoko Arimoto-Matsuzaki, and Yutaka Hata, each of whom appears as a coauthor on multiple publications.

The most common venues for Nishina's publications are Cancer Science and Genes to Cells, each hosting four of their papers. Other notable venues include the Journal of Biological Chemistry, Proceedings of the National Academy of Sciences, and Experimental Cell Research, where Nishina has published at least two articles each.

Best Publications

  • Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts.

    Hiroshi Takayanagi;Sunhwa Kim;Takako Koga;Takako Koga;Hiroshi Nishina

  • Estrogen Prevents Bone Loss via Estrogen Receptor α and Induction of Fas Ligand in Osteoclasts

    Takashi Nakamura;Yuuki Imai;Yuuki Imai;Takahiro Matsumoto;Shingo Sato

  • Autoamplification of NFATc1 expression determines its essential role in bone homeostasis.

    Masataka Asagiri;Kojiro Sato;Takako Usami;Sae Ochi

  • Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

    Kurt Wolfgang Bachmaier;Connie Krawczyk;Ivona Kozieradzki;Young Yun Kong

  • Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice.

    Isao Sakaida;Shuji Terai;Naoki Yamamoto;Koji Aoyama

  • WSX-1 Is Required for the Initiation of Th1 Responses and Resistance to L. major Infection

    Hiroki Yoshida;Hiroki Yoshida;Hiroki Yoshida;Shinjiro Hamano;Giorgio Senaldi;Todd Covey

  • Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor.

    K.-D. Fischer;Y.-Y. Kong;H. Nishina;K. Tedford

  • Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3

    Hiroshi Nishina;Klaus D. Fischer;Klaus D. Fischer;Laszlo Radvanyi;Arda Shahinian

  • The Transcription Factor NF-ATc1 Regulates Lymphocyte Proliferation and Th2 Cytokine Production

    Hiroki Yoshida;Hiroshi Nishina;Hiroshi Nishina;Hiroaki Takimoto;Hiroaki Takimoto;Luc E.M Marengère;Luc E.M Marengère

  • Isolation and characterization of fra-2, an additional member of the fos gene family

    Hiroshi Nishina;Hironori Sato;Takeshi Suzuki;Moriyuki Sato

  • Brca2 is required for embryonic cellular proliferation in the mouse.

    A. Suzuki;J. L. De La Pompa;J. L. De La Pompa;R. Hakem;R. Hakem;A. Elia;A. Elia

  • Difference in transcriptional regulatory function between c-Fos and Fra-2

    Takeshi Suzuki;Hiroyuki Okuno;Tetuso Yoshida;Toshinori Endo

  • YAP is essential for tissue tension to ensure vertebrate 3D body shape

    Sean Porazinski;Huijia Wang;Yoichi Asaoka;Martin Behrndt

  • An in vivo model for monitoring trans-differentiation of bone marrow cells into functional hepatocytes

    Shuji Terai;Isao Sakaida;Naoki Yamamoto;Kaoru Omori

  • A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function

    G. Gregory Neely;Keiji Kuba;Anthony Cammarato;Kazuya Isobe;Kazuya Isobe

  • Involvement of JNK in the regulation of autophagic cell death

    S Shimizu;A Konishi;Y Nishida;Y Nishida;T Mizuta

  • A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription.

    Yijun Bao;Kentaro Nakagawa;Zeyu Yang;Mitsunobu Ikeda

  • Physiological Roles of SAPK/JNK Signaling Pathway

    Hiroshi Nishina;Teiji Wada;Toshiaki Katada

  • Activation of Extracellular Signal-regulated Kinase by Ultraviolet Is Mediated through Src-dependent Epidermal Growth Factor Receptor Phosphorylation ITS IMPLICATION IN AN ANTI-APOPTOTIC FUNCTION

    Daiju Kitagawa;Shuhei Tanemura;Shinya Ohata;Nao Shimizu

  • Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4

    H. Nishina;C. Vaz;P. Billia;Mai Nghiem

Frequent Co-Authors

Toshiaki Katada
Toshiaki Katada Musashino University
Josef M. Penninger
Josef M. Penninger University of British Columbia
Tak W. Mak
Tak W. Mak Princess Margaret Cancer Centre
Akira Suzuki
Akira Suzuki Kobe University
Makoto Furutani-Seiki
Makoto Furutani-Seiki Yamaguchi University
Takehiko Sasaki
Takehiko Sasaki Tokyo Medical and Dental University
Yutaka Hata
Yutaka Hata Tokyo Medical and Dental University
Naoki Yamamoto
Naoki Yamamoto National University of Singapore
Kiwamu Okita
Kiwamu Okita Yamaguchi University
Andrew Wakeham
Andrew Wakeham Princess Margaret Cancer Centre

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