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Sakae Tanaka

Sakae Tanaka

D-Index & Metrics

Medicine

D-Index
91
Citations
37289
World Ranking
11605
National Ranking
342

Overview

Sakae Tanaka is affiliated with the University of Tokyo in Japan and primarily works in the field of Medicine, with significant contributions to Surgery, Orthopedics and Sports Medicine, Rheumatology, Pathology and Forensic Medicine, and Oncology. Their research covers a broad range of topics related to musculoskeletal health and surgical outcomes.

The main research topics associated with Tanaka include:

  • Total Knee Arthroplasty Outcomes
  • Orthopaedic implants and arthroplasty
  • Spine and Intervertebral Disc Pathology
  • Knee injuries and reconstruction techniques
  • Osteoarthritis Treatment and Mechanisms
  • Scoliosis diagnosis and treatment
  • Spinal Fractures and Fixation Techniques

Tanaka's recent notable publications span various aspects of bone and joint disorders as well as spinal pathologies. Some key papers include:

  • "Sclerostin: from bench to bedside," 2020, Journal of Bone and Mineral Metabolism
  • "Pathomechanism of intervertebral disc degeneration," 2020, JOR Spine
  • "Role of interleukin-6 in bone destruction and bone repair in rheumatoid arthritis," 2021, Autoimmunity Reviews
  • "Effect of Early vs Delayed Surgical Treatment on Motor Recovery in Incomplete Cervical Spinal Cord Injury With Preexisting Cervical Stenosis," 2021, JAMA Network Open
  • "Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development," 2022, Nature Communications

The scientist frequently collaborates with other researchers, including Shuji Taketomi, Hiroshi Inui, Ryota Yamagami, Yasushi Oshima, and Kohei Kawaguchi, indicating a consistent network of co-authors in related fields.

Tanaka's works are commonly published in several specific venues, with a substantial number of publications in:

  • Research Square (Research Square)
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Scientific Reports
  • BMC Musculoskeletal Disorders
  • Journal of Bone and Mineral Metabolism

Best Publications

  • Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

    Kojiro Sato;Ayako Suematsu;Kazuo Okamoto;Akira Yamaguchi

  • Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis.

    Noriko Komatsu;Kazuo Okamoto;Shinichiro Sawa;Tomoki Nakashima

  • Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6.

    T Tamura;N Udagawa;N Takahashi;C Miyaura

  • Involvement of receptor activator of nuclear factor κB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis

    Hiroshi Takayanagi;Hideharu Iizuka;Takuo Juji;Takumi Nakagawa

  • Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice.

    Asuka Naito;Sakura Azuma;Sakae Tanaka;Tsuyoshi Miyazaki

  • Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors.

    S Tanaka;N Takahashi;N Udagawa;T Tamura

  • Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation

    Fumiyo Ikeda;Riko Nishimura;Takuma Matsubara;Sakae Tanaka

  • Reciprocal Role of ERK and Nf-κb Pathways in Survival and Activation of Osteoclasts

    Tsuyoshi Miyazaki;Hideki Katagiri;Yumi Kanegae;Hiroshi Takayanagi

  • Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL–RANK signaling system

    Sakae Tanaka;Kozo Nakamura;Naoyuki Takahasi;Tatsuo Suda

  • Negative regulation of BMP/Smad signaling by Tob in osteoblasts.

    Yutaka Yoshida;Sakae Tanaka;Hisashi Umemori;Osamu Minowa

  • Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis: a 3-year follow-up of the ROAD study.

    N. Yoshimura;S. Muraki;H. Oka;S. Tanaka

  • Bcl-2 Lies Downstream of Parathyroid Hormone–related Peptide in a Signaling Pathway That Regulates Chondrocyte Maturation during Skeletal Development

    Michael Amling;Lynn Neff;Sakae Tanaka;Daisuke Inoue

  • Opposing Extracellular Signal-Regulated Kinase and Akt Pathways Control Schwann Cell Myelination

    Toru Ogata;Satoru Iijima;Satoru Iijima;Shinya Hoshikawa;Toshiki Miura

  • c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption

    Sakae Tanaka;Michael Amling;Lynn Neff;Anusch Peyman

  • Src Kinase Activity Is Essential for Osteoclast Function

    Tsuyoshi Miyazaki;Archana Sanjay;Lynn Neff;Sakae Tanaka

  • Negative Regulation of Osteoclastogenesis by Ectodomain Shedding of Receptor Activator of NF-κB Ligand

    Atsuhiko Hikita;Ikuo Yana;Hidetoshi Wakeyama;Masaki Nakamura

  • Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim.

    Toru Akiyama;Phillippe Bouillet;Tsuyoshi Miyazaki;Yuho Kadono

  • A possible mechanism of the specific action of bisphosphonates on osteoclasts: Tiludronate preferentially affects polarized osteoclasts having ruffled borders

    H. Murakami;N. Takahashi;T. Sasaki;N. Udagawa

  • Akt1 in Osteoblasts and Osteoclasts Controls Bone Remodeling

    Naohiro Kawamura;Fumitaka Kugimiya;Yasushi Oshima;Shinsuke Ohba

  • Tissue-type plasminogen activator acts as a cytokine that triggers intracellular signal transduction and induces matrix metalloproteinase-9 gene expression.

    Kebin Hu;Junwei Yang;Sakae Tanaka;Steven L. Gonias

Frequent Co-Authors

Kozo Nakamura
Kozo Nakamura Shinshu University
Hiroshi Kawaguchi
Hiroshi Kawaguchi University of Tokyo
Hiroshi Kawaguchi
Hiroshi Kawaguchi University of Tokyo
Ung-il Chung
Ung-il Chung University of Tokyo
Hiroshi Takayanagi
Hiroshi Takayanagi University of Tokyo
Kazuhiko Ishihara
Kazuhiko Ishihara University of Tokyo
Yoshiya Tanaka
Yoshiya Tanaka University of Occupational and Environmental Health Japan
Naoyuki Takahashi
Naoyuki Takahashi Matsumoto Dental University
Tsutomu Takeuchi
Tsutomu Takeuchi Keio University
Tatsuo Suda
Tatsuo Suda Saitama Medical University

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