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Hiroshi Kawaguchi

Hiroshi Kawaguchi

D-Index & Metrics

Biology and Biochemistry

D-Index
90
Citations
25957
World Ranking
2470
National Ranking
153

Overview

Hiroshi Kawaguchi is affiliated with the University of Tokyo in Japan and has contributed to the field of medicine with a focus on surgery, orthopedics and sports medicine, rheumatology, pharmacology, and biomedical engineering. Their research topics primarily include bone health and osteoporosis research, scoliosis diagnosis and treatment, hip and femur fractures, hip disorders and treatments, pelvic and acetabular injuries, osteoarthritis treatment and mechanisms, and lower extremity biomechanics and pathologies.

Their recent significant papers encompass:

  • Association between types of Modic changes in the lumbar region and low back pain in a large cohort: the Wakayama spine study (2020, European Spine Journal)
  • Relationship of sagittal spinal alignment with low back pain and physical performance in the general population (2021, Scientific Reports)
  • Trends in osteoporosis prevalence over a 10-year period in Japan: the ROAD study 2005-2015 (2022, Journal of Bone and Mineral Metabolism)
  • Serious Adverse Events With Romosozumab Use in Japanese Patients: Need for Clear Formulation of Contraindications Worldwide (2020, Journal of Bone and Mineral Research)
  • Possible involvement of the autonomic nervous system in cervical muscles of patients with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) (2021, BMC Musculoskeletal Disorders)

Their frequent co-authors include:

  • Hiroyuki Oka
  • Shigeyuki Muraki
  • Toru Akune
  • Sakae Tanaka
  • Kozo Nakamura

They have published consistently in several venues with the highest number of publications appearing in:

  • Scientific Reports
  • Journal of Bone and Mineral Metabolism
  • Archives of Osteoporosis
  • Osteoarthritis and Cartilage Open
  • European Spine Journal

Hiroshi Kawaguchi has also contributed to academic literature through book publication with Bloomsbury Academic eBooks, including the title A History of Economic Thought in Japan published in 2022.

Best Publications

  • Suppression of Aging in Mice by the Hormone Klotho

    Hiroshi Kurosu;Masaya Yamamoto;Jeremy D. Clark;Johanne V. Pastor

  • PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors

    Toru Akune;Shinsuke Ohba;Satoru Kamekura;Masayuki Yamaguchi

  • Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women: the research on osteoarthritis/osteoporosis against disability study.

    Noriko Yoshimura;Shigeyuki Muraki;Hiroyuki Oka;Akihiko Mabuchi

  • Surface grafting of artificial joints with a biocompatible polymer for preventing periprosthetic osteolysis

    Toru Moro;Yoshio Takatori;Kazuhiko Ishihara;Tomohiro Konno

  • Osteoarthritis development in novel experimental mouse models induced by knee joint instability.

    S. Kamekura;K. Hoshi;T. Shimoaka;U. Chung

  • Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

    Taku Saito;Atsushi Fukai;Akihiko Mabuchi;Toshiyuki Ikeda

  • The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage

    Toshiyuki Ikeda;Satoru Kamekura;Akihiko Mabuchi;Ikuyo Kou

  • Reduced Pain Hypersensitivity and Inflammation in Mice Lacking Microsomal Prostaglandin E Synthase-1

    Daisuke Kamei;Kiyofumi Yamakawa;Yui Takegoshi;Maya Mikami-Nakanishi

  • Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover.

    Naoshi Ogata;Daichi Chikazu;Naoto Kubota;Yasuo Terauchi

  • Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis: a 3-year follow-up of the ROAD study.

    N. Yoshimura;S. Muraki;H. Oka;S. Tanaka

  • Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways.

    Yusuke Shinoda;Masayuki Yamaguchi;Naoshi Ogata;Toru Akune

  • Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability

    Satoru Kamekura;Yosuke Kawasaki;Kazuto Hoshi;Takashi Shimoaka

  • Suppressive function of androgen receptor in bone resorption

    Hirotaka Kawano;Takashi Sato;Takashi Yamada;Takahiro Matsumoto

  • Polyion complex micelles from plasmid DNA and poly(ethylene glycol)-poly(L-lysine) block copolymer as serum-tolerable polyplex system: physicochemical properties of micelles relevant to gene transfection efficiency.

    Keiji Itaka;Kyosuke Yamauchi;Atsushi Harada;Kozo Nakamura

  • Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim.

    Toru Akiyama;Phillippe Bouillet;Tsuyoshi Miyazaki;Yuho Kadono

  • Cohort Profile: Research on Osteoarthritis/Osteoporosis Against Disability study

    Noriko Yoshimura;Shigeyuki Muraki;Hiroyuki Oka;Hiroshi Kawaguchi

  • Akt1 in Osteoblasts and Osteoclasts Controls Bone Remodeling

    Naohiro Kawamura;Fumitaka Kugimiya;Yasushi Oshima;Shinsuke Ohba

  • Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency.

    Zenjiro Maruyama;Carolina A. Yoshida;Tatsuya Furuichi;Norio Amizuka

  • In situ single cell observation by fluorescence resonance energy transfer reveals fast intra‐cytoplasmic delivery and easy release of plasmid DNA complexed with linear polyethylenimine

    Keiji Itaka;Atsushi Harada;Yuichi Yamasaki;Kozo Nakamura

  • [Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways].

    Yusuke Shinoda;Naoshi Ogata;Hiroshi Kawaguchi

Frequent Co-Authors

Kozo Nakamura
Kozo Nakamura Shinshu University
Ung-il Chung
Ung-il Chung University of Tokyo
Sakae Tanaka
Sakae Tanaka University of Tokyo
Kazuhiko Ishihara
Kazuhiko Ishihara University of Tokyo
Takashi Kadowaki
Takashi Kadowaki Toranomon Hospital
Tomohiro Konno
Tomohiro Konno Tohoku University
Makoto Kuro-o
Makoto Kuro-o Jichi Medical University
Keiji Itaka
Keiji Itaka Tokyo Medical and Dental University
Kari Stefansson
Kari Stefansson deCODE Genetics (Iceland)

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