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Medicine

D-Index
104
Citations
45948
World Ranking
6986
National Ranking
165

Overview

Makoto Kuro-o is affiliated with Jichi Medical University in Japan. Their research spans primarily the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Within these areas, their notable subfields of study include Nephrology, Molecular Biology, Genetics, Physiology, and Surgery.

The scientist's research topics cover a range of biomedical and clinical interests. Key topics include:

  • Parathyroid Disorders and Treatments
  • Dialysis and Renal Disease Management
  • Genetic Syndromes and Imprinting
  • Fibroblast Growth Factor Research
  • Magnesium in Health and Disease
  • Biomedical Research and Pathophysiology
  • Nutrition and Health in Aging

Makoto Kuro-o has contributed to several peer-reviewed publications. Some selected papers include:

  • "Calcium phosphate microcrystals in the renal tubular fluid accelerate chronic kidney disease progression", 2021, Journal of Clinical Investigation
  • "Intermittent fasting enhances long-term memory consolidation, adult hippocampal neurogenesis, and expression of longevity gene Klotho", 2021, Molecular Psychiatry
  • "Klotho and calciprotein particles as therapeutic targets against accelerated ageing", 2021, Clinical Science
  • "Mud in the blood: the role of protein-mineral complexes and extracellular vesicles in biomineralisation and calcification", 2020, Journal of Structural Biology
  • "Phosphate as a Pathogen of Arteriosclerosis and Aging", 2020, Journal of Atherosclerosis and Thrombosis

The venues where Makoto Kuro-o frequently publishes reflect their research focus. Notable publication venues include:

  • Scientific Reports
  • Experimental Gerontology
  • Medicine & Science in Sports & Exercise
  • Hypertension Research
  • Research Square (Research Square)

Collaboration is a key aspect of their work, with frequent co-authors including:

  • Keisei Kosaki
  • Seiji Maeda
  • Masahiro Matsui
  • Kunihiro Yamagata
  • Chie Saito

Best Publications

  • Mutation of the mouse klotho gene leads to a syndrome resembling ageing

    Makoto Kuro-o;Yutaka Matsumura;Hiroki Aizawa;Hiroshi Kawaguchi

  • FGF23 induces left ventricular hypertrophy

    Christian Faul;Ansel P. Amaral;Behzad Oskouei;Ming Chang Hu

  • Suppression of Aging in Mice by the Hormone Klotho

    Hiroshi Kurosu;Masaya Yamamoto;Jeremy D. Clark;Johanne V. Pastor

  • Regulation of Fibroblast Growth Factor-23 Signaling by Klotho

    Hiroshi Kurosu;Yasushi Ogawa;Masayoshi Miyoshi;Masaya Yamamoto

  • Klotho Deficiency Causes Vascular Calcification in Chronic Kidney Disease

    Ming Chang Hu;Mingjun Shi;Jianning Zhang;Henry Quiñones

  • The parathyroid is a target organ for FGF23 in rats

    Iddo Z. Ben-Dov;Hillel Galitzer;Vardit Lavi-Moshayoff;Regina Goetz

  • Tissue-specific Expression of βKlotho and Fibroblast Growth Factor (FGF) Receptor Isoforms Determines Metabolic Activity of FGF19 and FGF21

    Hiroshi Kurosu;Mihwa Choi;Yasushi Ogawa;Addie S. Dickson

  • Regulation of oxidative stress by the anti-aging hormone klotho

    Masaya Yamamoto;Jeremy D. Clark;Johanne V. Pastor;Prem Gurnani

  • IDENTIFICATION OF THE HUMAN KLOTHO GENE AND ITS TWO TRANSCRIPTS ENCODING MEMBRANE AND SECRETED KLOTHO PROTEIN

    Yutaka Matsumura;Hiroki Aizawa;Takako Shiraki-Iida;Ryozo Nagai

  • Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse.

    Klementina Fon Tacer;Angie L. Bookout;Xunshan Ding;Hiroshi Kurosu

  • βKlotho is required for metabolic activity of fibroblast growth factor 21

    Yasushi Ogawa;Hiroshi Kurosu;Masaya Yamamoto;Animesh Nandi

  • Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule

    Ming Chang Hu;Mingjun Shi;Jianning Zhang;Johanne Pastor

  • Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members

    Regina Goetz;Andrew Beenken;Omar A. Ibrahimi;Juliya Kalinina

  • Fibroblast Growth Factor 23 and Klotho: Physiology and Pathophysiology of an Endocrine Network of Mineral Metabolism

    Ming Chang Hu;Kazuhiro Shiizaki;Makoto Kuro-o;Orson W. Moe

  • Klotho Inhibits Transforming Growth Factor-β1 (TGF-β1) Signaling and Suppresses Renal Fibrosis and Cancer Metastasis in Mice

    Shigehiro Doi;Yonglong Zou;Osamu Togao;Johanne V. Pastor

  • The Klotho proteins in health and disease

    Makoto Kuro-o;Makoto Kuro-o

  • Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1

    Seung Kuy Cha;Bernardo Ortega;Hiroshi Kurosu;Kevin P. Rosenblatt

  • Klotho deficiency is an early biomarker of renal ischemia–reperfusion injury and its replacement is protective

    Ming-Chang Hu;Mingjun Shi;Jianning Zhang;Henry Quiñones

  • Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein

    Takako Shiraki-Iida;Hiroki Aizawa;Yutaka Matsumura;Susumu Sekine

  • Mutation of the mouse klotho gene leads to a syndrome resembling ageing

    M. Kuro-o;Y. Matsumura;H. Arawa;H. Kawaguchi

Frequent Co-Authors

Ryozo Nagai
Ryozo Nagai Jichi Medical University
Yoshio Yazaki
Yoshio Yazaki University of Tokyo
Masanori Aikawa
Masanori Aikawa Brigham and Women's Hospital
Orson W. Moe
Orson W. Moe The University of Texas Southwestern Medical Center
Yo-ichi Nabeshima
Yo-ichi Nabeshima Foundation for Biomedical Research
Ichiro Manabe
Ichiro Manabe Chiba University
Fumimaro Takaku
Fumimaro Takaku University of Tokyo
Florian Lang
Florian Lang University of Tübingen
Moosa Mohammadi
Moosa Mohammadi New York University Langone Medical Center
Hiroshi Kawaguchi
Hiroshi Kawaguchi University of Tokyo

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