His primary scientific interests are in Klotho, Endocrinology, Internal medicine, Fibroblast growth factor and Biochemistry. His Klotho study combines topics in areas such as Cancer research, Wnt signaling pathway, Extracellular, Cell biology and Exon. Kidney disease, Hormone, Kidney, Arteriosclerosis and Homeostasis are subfields of Endocrinology in which his conducts study.
His Fibroblast growth factor research is multidisciplinary, relying on both Signal transduction and Fibroblast growth factor 23. His Signal transduction study combines topics from a wide range of disciplines, such as Growth factor and Phosphorylation. Makoto Kuro-o has researched Biochemistry in several fields, including Presenilin and Amyloid precursor protein.
Internal medicine, Endocrinology, Klotho, Kidney disease and Cell biology are his primary areas of study. Internal medicine is closely attributed to Cardiology in his work. He interconnects Calcification, Calcium and Phosphate in the investigation of issues within Endocrinology.
Makoto Kuro-o has included themes like Receptor, Fibroblast growth factor, Signal transduction and Transgene in his Klotho study. His work carried out in the field of Kidney disease brings together such families of science as Nephrology, Nephron, Renal function, Urinary system and Biomarker. His Cell biology research includes themes of Gene isoform and Smooth muscle.
His main research concerns Internal medicine, Endocrinology, Klotho, Kidney disease and Kidney. His study in the field of Myocyte also crosses realms of Context. With his scientific publications, his incorporates both Klotho and Premature aging.
His biological study spans a wide range of topics, including Urinary system, Osteoporosis and Nephron, Renal function. In his study, Nucleic acid is strongly linked to Molecular biology, which falls under the umbrella field of Kidney. His FGF21 study also includes
His primary scientific interests are in Klotho, Internal medicine, Fibroblast growth factor 23, Endocrinology and Calcium. His Klotho research includes elements of FGF21, Receptor and Fibroblast growth factor. His work in Internal medicine is not limited to one particular discipline; it also encompasses Cardiology.
His Fibroblast growth factor 23 research includes themes of Cardiac function curve, Contractility, Patch clamp and Diastole. His Endocrinology research integrates issues from Ryanodine receptor and Ca2+/calmodulin-dependent protein kinase. His research in Calcium intersects with topics in Extracellular, Cancer research, Signal transduction and Intracellular.
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Makoto Kuro-o;Yutaka Matsumura;Hiroki Aizawa;Hiroshi Kawaguchi.
FGF23 induces left ventricular hypertrophy
Christian Faul;Ansel P. Amaral;Behzad Oskouei;Ming Chang Hu.
Journal of Clinical Investigation (2011)
Suppression of Aging in Mice by the Hormone Klotho
Hiroshi Kurosu;Masaya Yamamoto;Jeremy D. Clark;Johanne V. Pastor.
Regulation of Fibroblast Growth Factor-23 Signaling by Klotho
Hiroshi Kurosu;Yasushi Ogawa;Masayoshi Miyoshi;Masaya Yamamoto.
Journal of Biological Chemistry (2006)
Klotho Deficiency Causes Vascular Calcification in Chronic Kidney Disease
Ming Chang Hu;Mingjun Shi;Jianning Zhang;Henry Quiñones.
Journal of The American Society of Nephrology (2011)
The parathyroid is a target organ for FGF23 in rats
Iddo Z. Ben-Dov;Hillel Galitzer;Vardit Lavi-Moshayoff;Regina Goetz.
Journal of Clinical Investigation (2007)
Tissue-specific Expression of βKlotho and Fibroblast Growth Factor (FGF) Receptor Isoforms Determines Metabolic Activity of FGF19 and FGF21
Hiroshi Kurosu;Mihwa Choi;Yasushi Ogawa;Addie S. Dickson.
Journal of Biological Chemistry (2007)
IDENTIFICATION OF THE HUMAN KLOTHO GENE AND ITS TWO TRANSCRIPTS ENCODING MEMBRANE AND SECRETED KLOTHO PROTEIN
Yutaka Matsumura;Hiroki Aizawa;Takako Shiraki-Iida;Ryozo Nagai.
Biochemical and Biophysical Research Communications (1998)
Regulation of oxidative stress by the anti-aging hormone klotho
Masaya Yamamoto;Jeremy D. Clark;Johanne V. Pastor;Prem Gurnani.
Journal of Biological Chemistry (2005)
Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse.
Klementina Fon Tacer;Angie L. Bookout;Xunshan Ding;Hiroshi Kurosu.
Molecular Endocrinology (2010)
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