World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
74
Citations
22789
World Ranking
5527
National Ranking
175

Overview

Hon Cheung Lee is affiliated with Peking University Shenzhen Graduate School in China. Their research spans biochemistry, genetics, and molecular biology, with a significant focus on neuroscience. Key subfields in their work include physiology, molecular biology, sensory systems, toxicology, and oncology.

The scientist has contributed to advancing knowledge in calcium signaling and nucleotide metabolism, ion channels and receptors, signaling pathways in disease, and related topics such as bioactive compounds and antitumor agents, adenosine and purinergic signaling, PARP inhibition in cancer therapy, and glycosylation and glycoproteins research.

Some of the recent papers include:

  • "Permeant fluorescent probes visualize the activation of SARM1 and uncover an anti-neurodegenerative drug candidate" (2021, eLife)
  • "The calcium signaling enzyme CD38 - a paradigm for membrane topology defining distinct protein functions" (2021, Cell Calcium)
  • "A conformation-specific nanobody targeting the nicotinamide mononucleotide-activated state of SARM1" (2022, Nature Communications)
  • "GALA peptide improves the potency of nanobody-drug conjugates by lipid-induced helix formation" (2021, Chemical Communications)
  • "Base-Exchange Enabling the Visualization of SARM1 Activities in Sciatic Nerve-Injured Mice" (2023, ACS Sensors)

Frequent co-authors in their publications include Yong Zhao, Wan Hua Li, Wen Jie Zhu, Zhi Ying Zhao, and Yang Cai.

Their work has appeared in a variety of journals, with multiple publications in bioRxiv (Cold Spring Harbor Laboratory), and individual papers in eLife, Cell Calcium, Nature Communications, and Chemical Communications.

Best Publications

  • Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update.

    S. K. Sarin;M. Kumar;G. K. Lau;Z. Abbas

  • Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38

    M. Howard;J. C. Grimaldi;J. F. Bazan;F. E. Lund

  • Pyridine nucleotide metabolites stimulate calcium release from sea urchin egg microsomes desensitized to inositol trisphosphate.

    DL Clapper;TF Walseth;PJ Dargie;Hon Cheung Lee

  • Ca(2+)-induced Ca2+ release in sea urchin egg homogenates: modulation by cyclic ADP-ribose.

    Antony Galione;Hon Cheung Lee;William B. Busa

  • Structural determination of a cyclic metabolite of NAD+ with intracellular Ca2+-mobilizing activity.

    Hon Cheung Lee;T. F. Walseth;G. T. Bratt;R. N. Hayes

  • A Derivative of NADP Mobilizes Calcium Stores Insensitive to Inositol Trisphosphate and Cyclic ADP-ribose (∗)

    Hon Cheung Lee;Robert Aarhus

  • Physiological Functions of Cyclic ADP-Ribose and NAADP as Calcium Messengers

    Hon Cheung Lee

  • ADP-ribosyl cyclase and CD38 catalyze the synthesis of a calcium-mobilizing metabolite from NADP.

    Robert Aarhus;Richard M. Graeff;Deborah M. Dickey;Timothy F. Walseth

  • Abscisic acid signaling through cyclic ADP-ribose in plants

    Yan Wu;Jennifer Kuzma;Jennifer Kuzma;Eric Maréchal;Eric Maréchal;Richard M Graeff;Richard M Graeff

  • Mechanisms of calcium signaling by cyclic ADP-ribose and NAADP

    Hon Cheung Lee

  • Calcium mobilization by dual receptors during fertilization of sea urchin eggs

    Hon Cheung Lee;Robert Aarhus;Timothy F. Walseth

  • A Single Protein Immunologically Identified as CD38 Displays NAD+ Glycohydrolase, ADP-Ribosyl Cyclase and Cyclic ADP-Ribose Hydrolase Activities at the Outer Surface of Human Erythrocytes

    E. Zocchi;L. Franco;L. Guida;U. Benatti

  • Synthesis and characterization of antagonists of cyclic-ADP-ribose-induced Ca2+ release

    Timothy F. Walseth;Hon Cheung Lee

  • Enzymatic synthesis and characterizations of cyclic GDP-ribose. A procedure for distinguishing enzymes with ADP-ribosyl cyclase activity.

    R. M. Graeff;T. F. Walseth;K. Fryxell;W. D. Branton

  • Potentiation of calcium- and caffeine-induced calcium release by cyclic ADP-ribose.

    Hon Cheung Lee

  • Cyclic ADP ribose activation of the ryanodine receptor is mediated by calmodulin

    Hon Cheung Lee;Robert Aarhus;Richard M Graeff;Mary E. Gurnack

  • Similarities in amino acid sequences of Aplysia ADP-ribosyl cyclase and human lymphocyte antigen CD38.

    David J. States;Timothy F. Walseth;Hon Cheung Lee

  • Nitric Oxide-induced Mobilization of Intracellular Calcium via the Cyclic ADP-ribose Signaling Pathway

    Nick Willmott;Jaswinder K. Sethi;Timothy F. Walseth;Hon Cheung Lee

  • Changes in internal pH associated with initiation of motility and acrosome reaction of sea urchin sperm.

    Hon cheung Lee;Carl Johnson;David Epel

  • Widespread occurrence in animal tissues of an enzyme catalyzing the conversion of NAD+ into a cyclic metabolite with intracellular Ca2+-mobilizing activity.

    N Rusinko;H C Lee

Frequent Co-Authors

Timothy F. Walseth
Timothy F. Walseth University of Minnesota
Quan Hao
Quan Hao University of Hong Kong
Jianbo Yue
Jianbo Yue Duke Kunshan University
Kyle R. Gee
Kyle R. Gee Thermo Fisher Scientific (Norway)
Antony Galione
Antony Galione University of Oxford
Hong Jiang
Hong Jiang Nanjing Tech University
Haruhiro Higashida
Haruhiro Higashida Kanazawa University
Hening Lin
Hening Lin Howard Hughes Medical Institute
Friedrich Koch-Nolte
Friedrich Koch-Nolte Universität Hamburg
Barry V. L. Potter
Barry V. L. Potter University of Oxford

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