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Chemistry

D-Index
45
Citations
7341
World Ranking
16452
National Ranking
912

Biology and Biochemistry

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50
Citations
9271
World Ranking
17616
National Ranking
1389

Overview

Grant C. Churchill is affiliated with the University of Oxford in the United Kingdom. Their research spans multiple fields, primarily focusing on Medicine and Biochemistry, Genetics and Molecular Biology. Within these broader fields, their work delves into subfields such as Physiology, Molecular Biology, Infectious Diseases, Biochemistry, and Cellular and Molecular Neuroscience.

The main research topics addressed by Churchill include Lysosomal Storage Disorders Research, COVID-19 Clinical Research Studies, Amino Acid Enzymes and Metabolism, Calcium Signaling and Nucleotide Metabolism, Circadian Rhythm and Melatonin, Sleep and Wakefulness Research, and SARS-CoV-2 and COVID-19 Research.

Churchill has contributed to several scientific papers including:

  • Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice, 2021, Nature Communications
  • Randomised controlled trial of intravenous nafamostat mesylate in COVID pneumonitis: Phase 1b/2a experimental study to investigate safety, Pharmacokinetics and Pharmacodynamics, 2022, EBioMedicine
  • Unexpected differences in the pharmacokinetics of N-acetyl-DL-leucine enantiomers after oral dosing and their clinical relevance, 2020, PLoS ONE
  • Acetylation turns leucine into a drug by membrane transporter switching, 2021, Scientific Reports
  • A master protocol to investigate a novel therapy acetyl-l-leucine for three ultra-rare neurodegenerative diseases: Niemann-Pick type C, the GM2 gangliosidoses, and ataxia telangiectasia, 2021, Trials

Frequent co-authors who have collaborated with Churchill include:

  • Antony Galione
  • Frances M. Platt
  • Michael Strupp
  • Tatiana Brémovà-Ertl
  • Mallory Factor

Churchill's research has appeared in various publication venues with repeated contributions in bioRxiv (Cold Spring Harbor Laboratory). Other venues include Nature Communications, EBioMedicine, PLoS ONE, and Scientific Reports.

Best Publications

  • Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

    Emyr Lloyd-Evans;Anthony J Morgan;Xingxuan He;David A Smith

  • NAADP Mobilizes Ca2+ from Reserve Granules, Lysosome-Related Organelles, in Sea Urchin Eggs

    Grant C. Churchill;Yuhei Okada;Justyn M. Thomas;Armando A. Genazzani

  • Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells.

    Jose Manuel Cancela;Grant C. Churchill;Antony Galione

  • Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

    Patricia Gomez-Suaga;Berta Luzón-Toro;Dev Churamani;Ling-ling Zhang

  • Identification of a chemical probe for NAADP by virtual screening

    Edmund Naylor;Abdelilah Arredouani;Sridhar R. Vasudevan;Alexander M. Lewis

  • Purified TPC Isoforms Form NAADP Receptors with Distinct Roles for Ca2+ Signaling and Endolysosomal Trafficking

    Margarida Ruas;Katja Rietdorf;Abdelilah Arredouani;Lianne C. Davis

  • A safe lithium mimetic for bipolar disorder

    Nisha Singh;Amy C. Halliday;Justyn M. Thomas;Olga V. Kuznetsova

  • TPC2 Is a Novel NAADP-sensitive Ca2+ Release Channel, Operating as a Dual Sensor of Luminal pH and Ca2+

    Samantha Jane Pitt;Tim M Funnell;Mano Sitsapesan;Elisa Venturi

  • Organelle selection determines agonist-specific Ca2+ signals in pancreatic acinar and beta cells.

    Michiko Yamasaki;Roser Masgrau;Anthony J. Morgan;Grant C. Churchill

  • The CRTC1-SIK1 pathway regulates entrainment of the circadian clock.

    A Jagannath;R Butler;R Butler;Godinho Sih.;Godinho Sih.;Y Couch

  • NAADP induces Ca2+ oscillations via a two-pool mechanism by priming IP3- and cADPR-sensitive Ca2+ stores.

    Grant C Churchill;Antony Galione

  • Interactions between calcium release pathways: multiple messengers and multiple stores.

    A Galione;G C Churchill

  • Sperm deliver a new second messenger: NAADP.

    Grant C. Churchill;John S. O'Neill;Roser Masgrau;Sandip Patel

  • NAADP: a new second messenger for glucose-induced Ca2+ responses in clonal pancreatic beta cells.

    Roser Masgrau;Grant C. Churchill;Anthony J. Morgan;Stephen J.H. Ashcroft

  • Coordination of Ca2+ signalling by NAADP.

    Sandip Patel;Grant C. Churchill;Antony Galione

  • Bidirectional Ca2+ signaling occurs between the endoplasmic reticulum and acidic organelles

    Anthony J. Morgan;Lianne C. Davis;Siegfried K.T.Y. Wagner;Alexander M. Lewis

  • Role of NAADP and cADPR in the induction and maintenance of agonist-evoked Ca2+ spiking in mouse pancreatic acinar cells.

    Michiko Yamasaki;Justyn M. Thomas;Grant C. Churchill;Clive Garnham

  • NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing.

    Lianne C. Davis;Anthony J. Morgan;Ji Li Chen;Charlotte M. Snead

  • Functionalized bis(thiosemicarbazonato) complexes of zinc and copper: synthetic platforms toward site-specific radiopharmaceuticals.

    Jason P Holland;Franklin I Aigbirhio;Helen M Betts;Paul D Bonnitcha

  • Nicotinic acid adenine dinucleotide phosphate (NAADP) regulates autophagy in cultured astrocytes

    Gustavo J. S. Pereira;Hanako Hirata;Gian M. Fimia;Lucia G. do Carmo

Frequent Co-Authors

Antony Galione
Antony Galione University of Oxford
Sandip Patel
Sandip Patel University College London
Trevor Sharp
Trevor Sharp University of Oxford
Frances M. Platt
Frances M. Platt University of Oxford
John Parrington
John Parrington University of Oxford
Armando A. Genazzani
Armando A. Genazzani University of Eastern Piedmont Amadeo Avogadro
Guy M. Goodwin
Guy M. Goodwin University of Oxford
Michael Strupp
Michael Strupp Ludwig-Maximilians-Universität München
Philip J. Cowen
Philip J. Cowen University of Oxford
Catherine J. Harmer
Catherine J. Harmer University of Oxford

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