His primary scientific interests are in LRRK2, Kinase activity, Genetics, Parkinson's disease and Biochemistry. The various areas that Patrick A. Lewis examines in his LRRK2 study include Kinase, Cell biology and Cyclin-dependent kinase 2. His studies deal with areas such as Parkin, Disease and Alpha-synuclein as well as Genetics.
His Parkinson's disease research is multidisciplinary, incorporating perspectives in Putamen and Cellular pathology. As a part of the same scientific study, Patrick A. Lewis usually deals with the PI3K/AKT/mTOR pathway, concentrating on Autophagy and frequently concerns with Physiology. His Genome-wide association study study incorporates themes from Programmed cell death and Bioinformatics.
LRRK2, Parkinson's disease, Disease, Genetics and Cell biology are his primary areas of study. His studies in LRRK2 integrate themes in fields like Autophagy, GTPase and Leucine-rich repeat, Kinase, Kinase activity. His research on Autophagy frequently connects to adjacent areas such as Programmed cell death.
His study in Parkinson's disease is interdisciplinary in nature, drawing from both Neurodegeneration, Neuroscience, Parkinsonism and Bioinformatics. His study on Disease also encompasses disciplines like
Patrick A. Lewis focuses on Disease, LRRK2, Parkinson's disease, Cell biology and Gene. His biological study spans a wide range of topics, including Leucine-rich repeat, Kinase and Rab. His Parkinson's disease research incorporates elements of Pediatrics and MEDLINE.
His Cell biology research incorporates themes from Golgi apparatus, Loss function and Autophagy. His Autolysosome study in the realm of Autophagy interacts with subjects such as Interpretation and Set. His Gene research is multidisciplinary, incorporating elements of Computational biology and Bioinformatics.
Patrick A. Lewis mainly investigates Disease, Pathogenesis, Intracellular vesicle, Genetics and Context. His study of Parkinson's disease is a part of Disease. His Parkinson's disease study integrates concerns from other disciplines, such as Meta-analysis and Single-nucleotide polymorphism, Genetic association.
His Intracellular vesicle research covers fields of interest such as Kinase, Alzheimer's disease, Cell biology, LRRK2 and Amyotrophic lateral sclerosis. Patrick A. Lewis frequently studies issues relating to Parkinsonism and Genetics. His Genome-wide association study study combines topics in areas such as Genetic analysis, Mendelian inheritance, Alpha-synuclein and Bioinformatics.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin.
Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
Mike A Nalls;Cornelis Blauwendraat;Costanza L Vallerga;Karl Heilbron.
Lancet Neurology (2019)
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin.
Elisa Greggio;Shushant Jain;Ann Kingsbury;Rina Bandopadhyay.
Neurobiology of Disease (2006)
Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
Michael J. Devine;Mina Ryten;Petr Vodicka;Alison J. Thomson.
Nature Communications (2011)
Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences.
Claudia Manzoni;Demis A Kia;Jana Vandrovcova;John Hardy.
Briefings in Bioinformatics (2018)
α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?
Aoife P. Kiely;Yasmine T. Asi;Eleanna Kara;Patricia Limousin;Patricia Limousin.
Acta Neuropathologica (2013)
The Parkinson Disease-associated Leucine-rich Repeat Kinase 2 (LRRK2) Is a Dimer That Undergoes Intramolecular Autophosphorylation
Elisa Greggio;Ibardo Zambrano;Alice Kaganovich;Alexandra Beilina.
Journal of Biological Chemistry (2008)
The R1441C mutation of LRRK2 disrupts GTP hydrolysis.
Patrick A. Lewis;Elisa Greggio;Alexandra Beilina;Shushant Jain.
Biochemical and Biophysical Research Communications (2007)
The Parkinson's disease–linked proteins Fbxo7 and Parkin interact to mediate mitophagy
Victoria S Burchell;David E Nelson;Alvaro Sanchez-Martinez;Alvaro Sanchez-Martinez;Marta Delgado-Camprubi.
Nature Neuroscience (2013)
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