World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
14394
World Ranking
12414
National Ranking
393

Overview

Zhi-Jie Liu is affiliated with ShanghaiTech University in China and has established a research profile primarily in the areas of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans several specialized subfields, notably Molecular Biology, Cellular and Molecular Neuroscience, Pharmacology, Biomedical Engineering, and Infectious Diseases.

Their research covers a wide range of topics including:

  • Receptor Mechanisms and Signaling
  • Cannabis and Cannabinoid Research
  • Neuroscience and Neuropharmacology Research
  • Computational Drug Discovery Methods
  • Mass Spectrometry Techniques and Applications
  • SARS-CoV-2 and COVID-19 Research
  • Biochemical Analysis and Sensing Techniques

Their work has been published across multiple high-profile venues, with frequent publications in:

  • Nature Communications
  • Nature
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Protein & Cell
  • Journal of Medicinal Chemistry

Some of their recent papers include:

  • Structure of the RNA-dependent RNA polymerase from COVID-19 virus, 2020, Science
  • Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase, 2020, Cell
  • Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures, 2020, Cell
  • Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives, 2021, Nature Communications
  • Structural basis of CXC chemokine receptor 2 activation and signalling, 2020, Nature

Zhi-Jie Liu has worked extensively with several frequent co-authors, including Tian Hua, Lijie Wu, Yiran Wu, Suwen Zhao, and Li-Xia Peng. Collaborations have often contributed to advancing knowledge in their focus areas, particularly in structural biology and receptor signaling.

Best Publications

  • Structure of the RNA-dependent RNA polymerase from COVID-19 virus.

    Yan Gao;Yan Gao;Liming Yan;Yucen Huang;Fengjiang Liu

  • Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase.

    Quan Wang;Jiqin Wu;Haofeng Wang;Haofeng Wang;Yan Gao

  • Crystal Structure of the Human Cannabinoid Receptor CB2.

    Tian Hua;Kiran Vemuri;Mengchen Pu;Lu Qu;Lu Qu

  • Common activation mechanism of class A GPCRs.

    Qingtong Zhou;Dehua Yang;Meng Wu;Meng Wu;Yu Guo;Yu Guo

  • Crystal structures of agonist-bound human cannabinoid receptor CB1

    Tian Hua;Kiran Vemuri;Spyros P. Nikas;Robert B. Laprairie

  • Curved EFC/F-BAR-Domain Dimers Are Joined End to End into a Filament for Membrane Invagination in Endocytosis

    Atsushi Shimada;Hideaki Niwa;Kazuya Tsujita;Shiro Suetsugu;Shiro Suetsugu

  • The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response

    Kislay Parvatiyar;Zhiqiang Zhang;Rosane M. Teles;Songying Ouyang

  • The first structure of an aldehyde dehydrogenase reveals novel interactions between NAD and the Rossmann fold.

    Zhi-Jie Liu;Yuh-Ju Sun;John Rose;Yong-Je Chung

  • Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding

    Songying Ouyang;Xianqiang Song;Yaya Wang;Heng Ru

  • Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-GiComplex Structures.

    Tian Hua;Xiaoting Li;Lijie Wu;Christos Iliopoulos-Tsoutsouvas

  • NLRC3, a Member of the NLR Family of Proteins, Is a Negative Regulator of Innate Immune Signaling Induced by the DNA Sensor STING

    Lu Zhang;Jinyao Mo;Karen V. Swanson;Haitao Wen

  • Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.

    Bing Zhang;Bing Zhang;Jun Li;Jun Li;Xiaolin Yang;Xiaolin Yang;Lijie Wu

  • Structure of the Ca2+-regulated photoprotein obelin at 1.7 A resolution determined directly from its sulfur substructure.

    Zhi-Jie Liu;Eugene S. Vysotski;Chun-Jung Chen;John P. Rose

  • Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators

    Gaojie Song;Dehua Yang;Yuxia Wang;Chris de Graaf

  • Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives.

    Kangsa Amporndanai;Xiaoli Meng;Weijuan Shang;Zhenmig Jin

  • 5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.

    Yao Peng;Yao Peng;Yao Peng;John D. McCorvy;Kasper Harpsøe;Katherine Lansu

  • Structural basis of CXC chemokine receptor 2 activation and signalling

    Kaiwen Liu;Lijie Wu;Shuguang Yuan;Meng Wu;Meng Wu

  • Mechanism of class 1 (glycosylhydrolase family 47) {alpha}-mannosidases involved in N-glycan processing and endoplasmic reticulum quality control

    Khanita Karaveg;Aloysius Siriwardena;Wolfram Tempel;Zhi-Jie Liu

  • Life in the fast lane for protein crystallization and X-ray crystallography.

    Marc L Pusey;Zhi-Jie Liu;Wolfram Tempel;Jeremy Praissman

  • Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor.

    Yoshikawa S;Kukimoto-Niino M;Parker L;Handa N

Frequent Co-Authors

Bi-Cheng Wang
Bi-Cheng Wang University of Georgia
Raymond C. Stevens
Raymond C. Stevens University of Southern California
Ming-Wei Wang
Ming-Wei Wang Chinese Academy of Sciences
Zihe Rao
Zihe Rao Tsinghua University
Gye Won Han
Gye Won Han University of Southern California
Genhong Cheng
Genhong Cheng University of California, Los Angeles
Mikako Shirouzu
Mikako Shirouzu RIKEN Center for Biosystems Dynamics Research
David C. Richardson
David C. Richardson Duke University
Vsevolod Katritch
Vsevolod Katritch University of Southern California

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Zhi-Jie Liu

Trending Scientists