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Biology and Biochemistry

D-Index
88
Citations
25725
World Ranking
2722
National Ranking
166

Overview

Mikako Shirouzu is affiliated with the RIKEN Center for Biosystems Dynamics Research in Japan. Their work primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with notable subfields including Molecular Biology, Cell Biology, Cellular and Molecular Neuroscience, Oncology, and Genetics.

Their research topics focus on areas such as RNA modifications and cancer, RNA and protein synthesis mechanisms, photoreceptor and optogenetics research, RNA research and splicing, photosynthetic processes and mechanisms, microtubule and mitosis dynamics, and epigenetics and DNA methylation.

Mikako Shirouzu has contributed to numerous publications, with recent papers including:

  • Structural insights into tetraspanin CD9 function, 2020, Nature Communications
  • ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B, 2020, Molecular Cell
  • Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT, 2022, Science
  • Crystal structure of human acetylcholinesterase in complex with tacrine: Implications for drug discovery, 2022, International Journal of Biological Macromolecules
  • Structural insights into the HBV receptor and bile acid transporter NTCP, 2022, Nature

Throughout their career, Shirouzu has frequently collaborated with other researchers. Prominent coauthors include Toshiaki Hosaka, Shigeyuki Yokoyama, Mutsuko Kukimoto-Niino, Kazutaka Murayama, and Yuri Tomabechi.

The scientist has published multiple papers in well-known venues such as Nature Communications, bioRxiv (Cold Spring Harbor Laboratory), Communications Biology, Biomolecular NMR Assignments, and Nature Chemical Biology.

Best Publications

  • Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains.

    Hideo Ogiso;Ryuichiro Ishitani;Osamu Nureki;Shuya Fukai

  • Curved EFC/F-BAR-Domain Dimers Are Joined End to End into a Filament for Membrane Invagination in Endocytosis

    Atsushi Shimada;Hideaki Niwa;Kazuya Tsujita;Shiro Suetsugu;Shiro Suetsugu

  • Structural genomics projects in Japan.

    Shigeyuki Yokoyama;Hiroshi Hirota;Takanori Kigawa;Takashi Yabuki

  • Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase

    Kliment A. Verba;Ray Yu-Ruei Wang;Akihiko Arakawa;Yanxin Liu

  • Site-specific incorporation of an unnatural amino acid into proteins in mammalian cells.

    Kensaku Sakamoto;Akiko Hayashi;Ayako Sakamoto;Daisuke Kiga

  • Oncogenic Ras triggers cell suicide through the activation of a caspase-independent cell death program in human cancer cells

    Shunji Chi;Chifumi Kitanaka;Kohji Noguchi;Toshihiro Mochizuki

  • A computational model on the modulation of mitogen-activated protein kinase (MAPK) and Akt pathways in heregulin-induced ErbB signalling.

    Mariko Hatakeyama;Shuhei Kimura;Takashi Naka;Takuji Kawasaki

  • A Novel Zinc-binding Motif Revealed by Solution Structures of DNA-binding Domains of Arabidopsis SBP-family Transcription Factors ☆

    Kazuhiko Yamasaki;Takanori Kigawa;Makoto Inoue;Masaru Tateno

  • An engineered Escherichia coli tyrosyl–tRNA synthetase for site-specific incorporation of an unnatural amino acid into proteins in eukaryotic translation and its application in a wheat germ cell-free system

    Daisuke Kiga;Kensaku Sakamoto;Koichiro Kodama;Takanori Kigawa

  • SARS-CoV 3CL protease cleaves its C-terminal autoprocessing site by novel subsite cooperativity

    Tomonari Muramatsu;Chie Takemoto;Yong Tae Kim;Hongfei Wang

  • Solution structure of an Arabidopsis WRKY DNA binding domain.

    Kazuhiko Yamasaki;Takanori Kigawa;Makoto Inoue;Masaru Tateno;Masaru Tateno

  • DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses

    Yosuke Harada;Yoshihiko Tanaka;Masao Terasawa;Markus Pieczyk

  • Crystal structures of the human adiponectin receptors

    Hiroaki Tanabe;Yoshifumi Fujii;Miki Okada-Iwabu;Masato Iwabu;Masato Iwabu

  • Expression of G protein coupled receptors in a cell-free translational system using detergents and thioredoxin-fusion vectors.

    Goshi Ishihara;Mie Goto;Mihoro Saeki;Kaori Ito

  • Cysteine-rich region of Raf-1 interacts with activator domain of post-translationally modified Ha-Ras.

    Chang-Deng Hu;Ken-ichi Kariya;Masako Tamada;Kazuhito Akasaka

  • Structure of the complete elongation complex of RNA polymerase II with basal factors

    Haruhiko Ehara;Takeshi Yokoyama;Hideki Shigematsu;Shigeyuki Yokoyama

  • Pin1 and Par14 Peptidyl Prolyl Isomerase Inhibitors Block Cell Proliferation

    Takafumi Uchida;Mari Takamiya;Morito Takahashi;Hitoshi Miyashita

  • The RAC binding domain/IRSp53-MIM homology domain of IRSp53 induces RAC-dependent membrane deformation

    Shiro Suetsugu;Kazutaka Murayama;Ayako Sakamoto;Kyoko Hanawa-Suetsugu

  • Structural basis of replication origin recognition by the DnaA protein.

    Norie Fujikawa;Hitoshi Kurumizaka;Osamu Nureki;Takaho Terada

  • Structural basis for interaction of the ribosome with the switch regions of GTP-bound elongation factors.

    Sean R. Connell;Chie Takemoto;Daniel N. Wilson;Hongfei Wang

Frequent Co-Authors

Takaho Terada
Takaho Terada University of Tokyo
Takanori Kigawa
Takanori Kigawa RIKEN Center for Biosystems Dynamics Research
Seiki Kuramitsu
Seiki Kuramitsu Osaka University
Peter Güntert
Peter Güntert ETH Zurich
Osamu Nureki
Osamu Nureki University of Tokyo
Sumio Sugano
Sumio Sugano University of Tokyo
Jeremy R. H. Tame
Jeremy R. H. Tame Yokohama City University
So Iwata
So Iwata Kyoto University

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