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Leo A. van Grunsven

Leo A. van Grunsven

D-Index & Metrics

Biology and Biochemistry

D-Index
54
Citations
17646
World Ranking
15374
National Ranking
267

Overview

Leo A. van Grunsven is affiliated with the Vrije Universiteit Brussel in Belgium. Their research primarily focuses on medicine, with significant contributions to biochemistry, genetics, and molecular biology. Within these fields, van Grunsven's work has a strong emphasis on hepatology and molecular biology, alongside interests in epidemiology, surgery, and oncology.

The scientist's main research topics include liver physiology and pathology, liver disease diagnosis and treatment, pluripotent stem cells research, organ transplantation techniques and outcomes, pancreatic function and diabetes, 3D printing in biomedical research, and single-cell and spatial transcriptomics.

Van Grunsven has published extensively, with frequent contributions to several scientific venues. These include:

  • Journal of Hepatology (7 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (5 publications)
  • Cell Death and Disease (3 publications)
  • Biomaterials (3 publications)
  • Nature Communications (2 publications)

They have collaborated often with colleagues such as Stefaan Verhulst, Catherine M. Verfaillie, Ayla Smout, Vincent De Smet, and Nathalie Eysackers.

Recent selected papers include:

  • "Regeneration Defects in Yap and Taz Mutant Mouse Livers Are Caused by Bile Duct Disruption and Cholestasis" (2020, Gastroenterology)
  • "Hippo signaling instructs ectopic but not normal organ growth" (2022, Science)
  • "Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis" (2021, Cell Metabolism)
  • "Initiation of hepatic stellate cell activation extends into chronic liver disease" (2021, Cell Death and Disease)
  • "Current and emerging pharmacotherapeutic interventions for the treatment of liver fibrosis" (2020, Expert Opinion on Pharmacotherapy)

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche

    Johnny Bonnardel;Wouter T’Jonck;Djoere Gaublomme;Robin Browaeys

  • A role for autophagy during hepatic stellate cell activation.

    Lien F.R. Thoen;Eduardo L.M. Guimarães;Laurent Dollé;Inge Mannaerts

  • The Hippo pathway effector YAP controls mouse hepatic stellate cell activation

    Inge Mannaerts;Sofia Batista Leite;Stefaan Verhulst;Sofie Sofie Claerhout

  • Keratin 19: a key role player in the invasion of human hepatocellular carcinomas

    Olivier Govaere;Mina Komuta;Johannes Berkers;Bart Spee

  • Advanced glycation end products induce production of reactive oxygen species via the activation of NADPH oxidase in murine hepatic stellate cells.

    Eduardo L.M. Guimarães;Christophe Empsen;Albert Geerts;Leo A. van Grunsven

  • Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro

    Sofia B. Leite;Tiffany Roosens;Adil El Taghdouini;Inge Mannaerts

  • Liposome based systems for systemic siRNA delivery: stability in blood sets the requirements for optimal carrier design.

    Kevin Buyens;Stefaan C. De Smedt;Kevin Braeckmans;Joseph Demeester

  • FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis

    Len Verbeke;Inge Mannaerts;Robert Schierwagen;Olivier Govaere

  • Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis

    Mar Coll;Luis Perea;Ruben Boon;Sofia B. Leite

  • The Biliary Epithelium Gives Rise to Liver Progenitor Cells

    Daniel Rodrigo-Torres;Silvia Affò;Mar Coll;Oriol Morales-Ibanez

  • Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice

    Iván M. Moya;Iván M. Moya;Stéphanie A. Castaldo;Laura van den Mooter;Soheil Soheily

  • 3D in vitro models of liver fibrosis

    Leo A van Grunsven

  • Chronic administration of valproic acid inhibits activation of mouse hepatic stellate cells in vitro and in vivo.

    Inge Mannaerts;Nele Nuytten;Vera Rogiers;Karin Vanderkerken

  • Atypical Mowat–Wilson patient confirms the importance of the novel association between ZFHX1B/SIP1 and NuRD corepressor complex

    Griet Verstappen;Leonardus Van Grunsven;Leonardus Van Grunsven;Christine Michiels;Christine Michiels;Tom Van de Putte;Tom Van de Putte

  • Laminin-332 sustains chemoresistance and quiescence as part of the human hepatic cancer stem cell niche.

    Olivier Govaere;Jasper Wouters;Michaela Petz;Yves-Paul Vandewynckel

  • EpCAM and the biology of hepatic stem/progenitor cells

    Laurent Dollé;Neil D. Theise;Eva Schmelzer;Luke Boulter

  • Blebbistatin inhibits contraction and accelerates migration in mouse hepatic stellate cells

    Zhenan Liu;Leo A. van Grunsven;Elke Van Rossen;Ben Schroyen

  • Inhibition of placental growth factor activity reduces the severity of fibrosis, inflammation, and portal hypertension in cirrhotic mice.

    Christophe Van Steenkiste;Jordi Ribera;Anja Geerts;Montse Pauta

  • The quest for liver progenitor cells: a practical point of view.

    Laurent Dollé;Jan Best;Jie Mei;Feras Al Battah

Frequent Co-Authors

Etienne Sokal
Etienne Sokal Université Catholique de Louvain
Tania Roskams
Tania Roskams KU Leuven
Laurence Lagneaux
Laurence Lagneaux Université Libre de Bruxelles
Georg Halder
Georg Halder KU Leuven
James C. Smith
James C. Smith The Francis Crick Institute
Juan José Lozano
Juan José Lozano Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
Vera Rogiers
Vera Rogiers Vrije Universiteit Brussel
Mathieu Vinken
Mathieu Vinken Vrije Universiteit Brussel

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