World's Best Scientists 2026 revealed!
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Best Female Scientists
2025
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Immunology
Canada
2026

D-Index & Metrics

Best Female Scientists

D-Index
120
Citations
61211
World Ranking
554
National Ranking
16

Immunology

D-Index
124
Citations
64212
World Ranking
295
National Ranking
4

Medicine

D-Index
124
Citations
64281
World Ranking
3197
National Ranking
134

Research.com Recognitions

  • 2026 - Research.com Immunology in Canada Leader Award
  • 2025 - Research.com Best Female Scientists Award
  • 2025 - Research.com Immunology in Canada Leader Award
  • 2023 - Research.com Immunology in Canada Leader Award
  • 2022 - Research.com Immunology in Canada Leader Award
  • 2018 - Robert L. Noble Prize, Canadian Cancer Society
  • 2006 - Fellow of the Royal Society of Canada Academy of Science
  • 2003 - AAI-BD Biosciences Investigator Award, American Association of Immunologists

Overview

Pamela S. Ohashi is affiliated with the Princess Margaret Cancer Centre in Canada, specializing in research across medicine, immunology, and microbiology. Their work spans significant subfields including immunology, oncology, molecular biology, cancer research, and surgery, reflecting a broad engagement with both basic and applied biomedical sciences.

The scientist's research topics focus predominantly on cancer immunotherapy and biomarkers, immune cell function and interaction, and immunotherapy and immune responses. Additional notable areas of study include CAR-T cell therapy research, cancer genomics and diagnostics, IL-33, ST2, and ILC pathways, and the role of immune cells within cancer.

Recent publications demonstrate ongoing contributions to immunology and cancer biology. Notable papers include:

  • "Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity," 2022, Immunity
  • "The Roles of CD8+ T Cell Subsets in Antitumor Immunity," 2020, Trends in Cell Biology
  • "Personalized circulating tumor DNA analysis as a predictive biomarker in solid tumor patients treated with pembrolizumab," 2020, Nature Cancer
  • "Multicenter International Society for Immunotherapy of Cancer Study of the Consensus Immunoscore for the Prediction of Survival and Response to Chemotherapy in Stage III Colon Cancer," 2020, Journal of Clinical Oncology
  • "Mechanical Stiffness Controls Dendritic Cell Metabolism and Function," 2021, Cell Reports

Frequent co-authors with whom the scientist has collaborated include Trevor J. Pugh, Ben X. Wang, Adrian G. Sacher, Azin Sayad, and Alisha R. Elford. These collaborations suggest a network of partnerships primarily in oncological and immunological research.

The main publication venues for this scientist's work highlight a focus on clinical and immunological journals. These include:

  • Journal of Clinical Oncology
  • The Journal of Immunology
  • Cancer Research
  • Cancer Immunology Research
  • Annals of Oncology

Throughout their career, they have been recognized with several awards, including the Robert L. Noble Prize from the Canadian Cancer Society in 2018, Fellowship in the Royal Society of Canada (Academy of Science) in 2006, and the AAI-BD Biosciences Investigator Award from the American Association of Immunologists in 2003.

Best Publications

  • LPS/TLR4 signal transduction pathway

    Yong-Chen Lu;Wen-Chen Yeh;Wen-Chen Yeh;Pamela S. Ohashi;Pamela S. Ohashi

  • Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

    Young-Yun Kong;Ulrich Feige;Iidiko Sarosi;Brad Bolon

  • Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection.

    Klaus Pfeffer;Toshifumi Matsuyama;Thomas M. Kündig;Andrew Wakeham

  • International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study

    Franck Pagès;Bernhard Mlecnik;Florence Marliot;Gabriela Bindea;Gabriela Bindea;Gabriela Bindea

  • Differential T cell costimulatory requirements in CD28-deficient mice

    Arda Shahinian;Klaus Pfeffer;Kelvin P. Lee;Thomas M. Kündig

  • Towards the introduction of the 'Immunoscore' in the classification of malignant tumours.

    Jérôme Galon;Jérôme Galon;Jérôme Galon;Bernhard Mlecnik;Bernhard Mlecnik;Bernhard Mlecnik;Gabriela Bindea;Gabriela Bindea;Gabriela Bindea;Helen K. Angell;Helen K. Angell;Helen K. Angell

  • Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice.

    Pamela S. Ohashi;Stephan Oehen;Kurt Buerki;Hanspeter Pircher

  • Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration

    Takehiko Sasaki;Junko Irie-Sasaki;Junko Irie-Sasaki;Russell G. Jones;Antonio J. Oliveira-dos-Santos

  • Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

    Nobutaka Suzuki;Shinobu Suzuki;Gordon S. Duncan;Douglas G. Millar

  • Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta

    Haruhiko Suzuki;Haruhiko Suzuki;Thomas M. Kündig;Caren Furlonger;Andrew Wakeham;Andrew Wakeham

  • Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

    Wen-Chen Yeh;Arda Shahinian;Daniel I Speiser;Janine Kraunus

  • Cancer classification using the Immunoscore: a worldwide task force

    Jérôme Galon;Franck Pagès;Francesco M Marincola;Francesco M Marincola;Helen K Angell;Helen K Angell

  • ICOS is essential for effective T-helper-cell responses.

    Anna Tafuri;Arda Shahinian;Arda Shahinian;Friedhelm Bladt;Steve K. Yoshinaga

  • Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function

    Hans-Willi Mittrücker;Toshifumi Matsuyama;Alex Grossman;Thomas M. Kündig

  • Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity.

    Unknown

  • Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

    Kurt Wolfgang Bachmaier;Connie Krawczyk;Ivona Kozieradzki;Young Yun Kong

  • Clinical blockade of PD1 and LAG3 — potential mechanisms of action

    Linh T. Nguyen;Pamela S. Ohashi

  • Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development

    Toshifumi Matsuyama;Toshifumi Matsuyama;Tohru Kimura;Tohru Kimura;Tohru Kimura;Motoo Kitagawa;Klaus Pfeffer;Klaus Pfeffer

  • T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

    Akira Suzuki;Manae Tsukio Yamaguchi;Toshiaki Ohteki;Takehiko Sasaki

  • Bcl10 Is a Positive Regulator of Antigen Receptor–Induced Activation of NF-κ B and Neural Tube Closure

    Jürgen Ruland;Jürgen Ruland;Gordon S Duncan;Gordon S Duncan;Andrew Elia;Andrew Elia;Ivan del Barco Barrantes;Ivan del Barco Barrantes

  • SELECTION OF THE T CELL REPERTOIRE

    Eric Sebzda;Sanjeev Mariathasan;Toshiaki Ohteki;Russell Jones

Frequent Co-Authors

Tak W. Mak
Tak W. Mak Princess Margaret Cancer Centre
Andrew Wakeham
Andrew Wakeham Princess Margaret Cancer Centre
Josef M. Penninger
Josef M. Penninger University of British Columbia
Martin F. Bachmann
Martin F. Bachmann University of Bern
Tak W. Mak
Tak W. Mak Princess Margaret Cancer Centre
Philipp A. Lang
Philipp A. Lang Heinrich Heine University Düsseldorf
Karl S. Lang
Karl S. Lang University of Duisburg-Essen
Hans Hengartner
Hans Hengartner University of Zurich
Trevor J. Pugh
Trevor J. Pugh Princess Margaret Cancer Centre
Daniel E. Speiser
Daniel E. Speiser University of Lausanne

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