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Biology and Biochemistry

D-Index
81
Citations
49283
World Ranking
3783
National Ranking
121

Overview

Trevor J. Pugh is a researcher affiliated with the Princess Margaret Cancer Centre in Canada. Their work spans several areas within medicine, biochemistry, genetics, and molecular biology. With a focus on oncology, cancer research, molecular biology, genetics, and pulmonary and respiratory medicine, their research addresses multiple intersecting subfields in biomedical science.

The scientist's primary fields of study include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these fields, the principal subfields of research include:

  • Molecular Biology
  • Oncology
  • Cancer Research
  • Genetics
  • Pulmonary and Respiratory Medicine

Trevor J. Pugh's research topics frequently cover the following areas:

  • Cancer Genomics and Diagnostics
  • Cancer Immunotherapy and Biomarkers
  • Genetic factors in colorectal cancer
  • Multiple Myeloma Research and Treatments
  • Epigenetics and DNA Methylation
  • Glioma Diagnosis and Treatment
  • Single-cell and spatial transcriptomics

Prominent recent publications by Trevor J. Pugh include the following papers:

  • "Analysis and Visualization of Longitudinal Genomic and Clinical Data from the AACR Project GENIE Biopharma Collaborative in cBioPortal," 2023, Cancer Research
  • "Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity," 2022, Immunity
  • "Personalized circulating tumor DNA analysis as a predictive biomarker in solid tumor patients treated with pembrolizumab," 2020, Nature Cancer
  • "Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy," 2021, Cell
  • "Neoadjuvant and Adjuvant Pembrolizumab in Resectable Locally Advanced, Human Papillomavirus-Unrelated Head and Neck Cancer: A Multicenter, Phase II Trial," 2020, Clinical Cancer Research

Their frequent co-authors include:

  • Lillian L. Siu
  • Anna Spreafico
  • Jeffrey P. Bruce
  • Leslie E. Oldfield
  • Pamela S. Ohashi

Trevor J. Pugh has published extensively in several scientific venues, with notable contributions to:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Clinical Oncology
  • Clinical Cancer Research
  • Nature Communications

The scientific output of Trevor J. Pugh reflects a broad and interdisciplinary approach to cancer biology and clinical research, emphasizing molecular mechanisms, diagnostics, and immunotherapy within oncology and genetic contexts.

Best Publications

  • Mutational heterogeneity in cancer and the search for new cancer-associated genes

    Michael S. Lawrence;Petar Stojanov;Petar Stojanov;Paz Polak;Paz Polak;Paz Polak;Gregory V. Kryukov;Gregory V. Kryukov;Gregory V. Kryukov

  • Comprehensive molecular characterization of urothelial bladder carcinoma

    John N Weinstein;Rehan Akbani;Bradley McIntosh Broom;Wenyi Wang

  • Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing

    Marcin Imielinski;Alice H. Berger;Alice H. Berger;Peter S. Hammerman;Peter S. Hammerman;Bryan Hernandez

  • AACR project genie: Powering precision medicine through an international consortium

    S. M. Sweeney;E. Cerami;A. Baras;T. J. Pugh

  • Initial genome sequencing and analysis of multiple myeloma

    Michael A. Chapman;Michael S. Lawrence;Jonathan J. Keats;Kristian Cibulskis

  • The genomic complexity of primary human prostate cancer

    Michael F. Berger;Michael F. Berger;Michael S. Lawrence;Francesca Demichelis;Yotam Drier

  • Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors

    Esra A. Akbay;Esra A. Akbay;Shohei Koyama;Julian Carretero;Abigail Altabef;Abigail Altabef

  • DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts.

    David Roulois;Helen Loo Yau;Helen Loo Yau;Rajat Singhania;Yadong Wang

  • Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution

    Sohrab P. Shah;Ryan D. Morin;Jaswinder Khattra;Leah Prentice

  • The genetic landscape of high-risk neuroblastoma

    Trevor J Pugh;Olena Morozova;Edward F Attiyeh;Edward F Attiyeh;Shahab Asgharzadeh;Shahab Asgharzadeh

  • Dissecting the genomic complexity underlying medulloblastoma

    David T. W. Jones;Natalie Jäger;Marcel Kool;Thomas Zichner

  • Melanoma genome sequencing reveals frequent PREX2 mutations

    Michael F. Berger;Michael F. Berger;Eran Hodis;Timothy P. Heffernan;Timothy P. Heffernan;Yonathan Lissanu Deribe

  • Landscape of genomic alterations in cervical carcinomas

    Akinyemi I. Ojesina;Lee Lichtenstein;Samuel S. Freeman;Chandra Sekhar Pedamallu

  • Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations

    Trevor J Pugh;Trevor J Pugh;Shyamal Dilhan Weeraratne;Shyamal Dilhan Weeraratne;Tenley C. Archer;Tenley C. Archer;Daniel A. Pomeranz Krummel

  • Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

    Marcel Kool;David T.W. Jones;Natalie Jäger;Paul A. Northcott

  • Prediction of acute myeloid leukaemia risk in healthy individuals

    Sagi Abelson;Grace Collord;Grace Collord;Stanley W.K. Ng;Omer Weissbrod

  • Sensitive tumour detection and classification using plasma cell-free DNA methylomes

    Shu Yi Shen;Rajat Singhania;Gordon Fehringer;Ankur Chakravarthy

  • Discovery and characterization of artifactual mutations in deep coverage targeted capture sequencing data due to oxidative DNA damage during sample preparation

    Maura Costello;Trevor J. Pugh;Timothy J. Fennell;Chip Stewart

  • Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

    S. C. Mack;H. Witt;R. M. Piro;L. Gu

  • Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas

    Tanguy Y Seiwert;Zhixiang Zuo;Michaela K Keck;Arun Khattri

Frequent Co-Authors

Matthew Meyerson
Matthew Meyerson Harvard University
Marco A. Marra
Marco A. Marra University of British Columbia
Pamela S. Ohashi
Pamela S. Ohashi Princess Margaret Cancer Centre
Mathieu Lupien
Mathieu Lupien Princess Margaret Cancer Centre
Gad Getz
Gad Getz Broad Institute
Amit M. Oza
Amit M. Oza Princess Margaret Cancer Centre
Eric S. Lander
Eric S. Lander Broad Institute
Michael S. Lawrence
Michael S. Lawrence Harvard University
Michael D. Taylor
Michael D. Taylor University of Toronto
Frances A. Shepherd
Frances A. Shepherd Princess Margaret Cancer Centre

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