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P. Leif Bergsagel

P. Leif Bergsagel

D-Index & Metrics

Medicine

D-Index
107
Citations
47896
World Ranking
6189
National Ranking
3300

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

P. Leif Bergsagel is affiliated with the Mayo Clinic in the United States. The scientist's research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant specializations in Hematology, Molecular Biology, Oncology, Genetics, and Immunology.

The main topics explored in Bergsagel's work include:

  • Multiple Myeloma Research and Treatments
  • Protein Degradation and Inhibitors
  • CAR-T Cell Therapy Research
  • Peptidase Inhibition and Analysis
  • Chronic Lymphocytic Leukemia Research
  • Ubiquitin and Proteasome Pathways
  • Cancer Mechanisms and Therapy

The scientist has contributed to many publications in notable journals. Frequent publication venues are:

  • Blood
  • Blood Cancer Journal
  • Journal of Clinical Oncology
  • Blood Cancer Discovery
  • Hematology/Oncology Clinics of North America

Selected recent papers include:

  • Treatment of relapsed and refractory multiple myeloma: recommendations from the International Myeloma Working Group, 2021, The Lancet Oncology
  • Genomic Profiling of Smoldering Multiple Myeloma Identifies Patients at a High Risk of Disease Progression, 2020, Journal of Clinical Oncology
  • Genomic profiling for clinical decision making in lymphoid neoplasms, 2022, Blood
  • Targeting cancer-associated fibroblasts in the bone marrow prevents resistance to CART-cell therapy in multiple myeloma, 2022, Blood
  • Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma, 2021, Cell Metabolism

Frequent co-authors in Bergsagel's research include:

  • Shaji Kumar
  • Rafaël Fonseca
  • Marta Chesi
  • S. Vincent Rajkumar
  • Taxiarchis Kourelis

Bergsagel has been recognized as a Member of the Association of American Physicians.

Best Publications

  • BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

    Jake E. Delmore;Ghayas C. Issa;Madeleine E. Lemieux;Peter B. Rahl

  • Initial genome sequencing and analysis of multiple myeloma

    Michael A. Chapman;Michael S. Lawrence;Jonathan J. Keats;Kristian Cibulskis

  • Promiscuous Mutations Activate the Noncanonical NF-κB Pathway in Multiple Myeloma

    Jonathan J. Keats;Rafael Fonseca;Marta Chesi;Roelandt Schop

  • International Myeloma Working Group molecular classification of multiple myeloma: spotlight review.

    R Fonseca;P L Bergsagel;J Drach;J Shaughnessy

  • Multiple myeloma: evolving genetic events and host interactions

    W. Michael Kuehl;P. Leif Bergsagel

  • Genetics and Cytogenetics of Multiple Myeloma A Workshop Report

    Rafael Fonseca;Bart Barlogie;Regis Bataille;Christian Bastard

  • Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma

    P. Leif Bergsagel;W. Michael Kuehl;Fenghuang Zhan;Jeffrey Sawyer

  • Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3.

    Chesi M;Nardini E;Brents La;Schröck E

  • Advances in biology of multiple myeloma: clinical applications

    Teru Hideshima;P. Leif Bergsagel;W. Michael Kuehl;Kenneth C. Anderson

  • Clonal competition with alternating dominance in multiple myeloma

    Jonathan J. Keats;Marta Chesi;Jan B. Egan;Victoria M. Garbitt

  • Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling

    Sivakumar Vallabhapurapu;Atsushi Matsuzawa;Wei Zhou Zhang;Ping Hui Tseng

  • Molecular Pathogenesis and a Consequent Classification of Multiple Myeloma

    P. Leif Bergsagel;W. Michael Kuehl

  • The t(4;14) Translocation in Myeloma Dysregulates Both FGFR3 and a Novel Gene, MMSET, Resulting in IgH/MMSET Hybrid Transcripts

    Marta Chesi;Marta Chesi;Elena Nardini;Elena Nardini;Robert S.C. Lim;Robert S.C. Lim;Kerrington D. Smith;Kerrington D. Smith

  • Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide.

    Yuan Xiao Zhu;Esteban Braggio;Chang Xin Shi;Laura A. Bruins

  • Management of Newly Diagnosed Symptomatic Multiple Myeloma: updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) Consensus Guidelines

    Shaji K. Kumar;Joseph R. Mikhael;Francis K. Buadi;David Dingli

  • Chromosome translocations in multiple myeloma.

    P Leif Bergsagel;W Michael Kuehl

  • MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

    Huadong Pei;Lindsey Zhang;Kuntian Luo;Yuxin Qin

  • Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma

    Marta Chesi;Marta Chesi;P. Leif Bergsagel;P. Leif Bergsagel;Oluwatoyin O. Shonukan;Oluwatoyin O. Shonukan;Maria Luisa Martelli;Maria Luisa Martelli

  • Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides

    Jan B. Egan;Chang Xin Shi;Waibhav Tembe;Alexis Christoforides

  • Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma

    P. Leif Bergsagel;Marta Chesi;Elena Nardini;Leslie A. Brents

Frequent Co-Authors

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