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Biology and Biochemistry

D-Index
74
Citations
18009
World Ranking
5650
National Ranking
439

Overview

Leonard W. Seymour is affiliated with the University of Oxford in the United Kingdom. Their research spans multiple fields with a strong focus on biochemistry, genetics, molecular biology, and medicine, reflecting a multidisciplinary approach to cancer and immunotherapy studies.

The main fields of study associated with their work include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these domains, Leonard's research engages with several specialized subfields such as:

  • Oncology
  • Genetics
  • Molecular Biology
  • Immunology
  • Biotechnology

The prominent topics that feature across Leonard W. Seymour's publications involve:

  • CAR-T cell therapy research
  • Virus-based gene therapy research
  • Cancer Research and Treatments
  • Viral Infectious Diseases and Gene Expression in Insects
  • Immune Cell Function and Interaction
  • Immunotherapy and Immune Responses
  • Cancer Immunotherapy and Biomarkers

Leonard has contributed to a substantial number of articles, frequently publishing in these scientific venues:

  • Journal for ImmunoTherapy of Cancer
  • Cancers
  • British Journal of Cancer
  • Cancer Immunology Research
  • Nature Biotechnology

Some of the recent and notable publications include:

  • Peptide-TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens, 2020, Nature Biotechnology
  • Promises and challenges of adoptive T-cell therapies for solid tumours, 2021, British Journal of Cancer
  • Deregulation of HLA-I in cancer and its central importance for immunotherapy, 2021, Journal for ImmunoTherapy of Cancer
  • Interfaces between cellular responses to DNA damage and cancer immunotherapy, 2021, Genes & Development
  • Beyond cancer cells: Targeting the tumor microenvironment with gene therapy and armed oncolytic virus, 2021, Molecular Therapy

In their collaborative efforts, Leonard frequently coauthors papers with:

  • Richard Baugh
  • Hena Khalique
  • Sally Frost
  • Kerry Fisher
  • Peter Kok-Ting Wan

Best Publications

  • Effect of molecular weight (Mw) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats.

    L. W. Seymour;R. Duncan;J. Strohalm;Jindrich Kopecek

  • Factors affecting blood clearance and in vivo distribution of polyelectrolyte complexes for gene delivery.

    P R Dash;M L Read;L B Barrett;M A Wolfert

  • Hepatic Drug Targeting: Phase I Evaluation of Polymer-Bound Doxorubicin

    Leonard W. Seymour;David R. Ferry;David Anderson;Stuart Hesslewood

  • In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity

    Geoffrey M Lynn;Geoffrey M Lynn;Richard Laga;Richard Laga;Patricia A Darrah;Andrew S Ishizuka

  • Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies

    K D Fisher;Y Stallwood;N K Green;K Ulbrich

  • Novel vectors for gene delivery formed by self-assembly of DNA with poly(L-lysine) grafted with hydrophilic polymers.

    Veska Toncheva;Margreet A Wolfert;Philip R Dash;David Oupicky

  • Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation

    David Oupicky;Manfred Ogris;Kenneth A. Howard;Philip R. Dash

  • Peptide-mediated RNA delivery: a novel approach for enhanced transfection of primary and post-mitotic cells

    Thierry Bettinger;Robert C. Carlisle;Martin L. Read;Manfred Ogris

  • Key issues in non-viral gene delivery1PII of original article: S0169-409X(98)00048-9. The article was originally published in Advanced Drug Delivery Reviews 34 (1998) 3–19.1

    Colin W Pouton;Leonard W Seymour

  • Polyelectrolyte vectors for gene delivery: influence of cationic polymer on biophysical properties of complexes formed with DNA.

    Margreet A. Wolfert;Philip R. Dash;Ola Nazarova;David Oupicky

  • Poly(ethylene glycol) multiblock copolymer as a carrier of anti-cancer drug doxorubicin.

    Michal Pechar;Karel Ulbrich;Vladimír Šubr;Leonard W. Seymour

  • Peptide–TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens

    Geoffrey M. Lynn;Christine Sedlik;Christine Sedlik;Faezzah Baharom;Yaling Zhu

  • Control of tumour vascular permeability.

    Dilair F Baban;Leonard W Seymour

  • Melittin enables efficient vesicular escape and enhanced nuclear access of nonviral gene delivery vectors.

    Manfred Ogris;Robert C. Carlisle;Thierry Bettinger;Leonard W. Seymour

  • Laterally stabilized complexes of DNA with linear reducible polycations: strategy for triggered intracellular activation of DNA delivery vectors.

    David Oupický;and Alan L. Parker;Leonard W. Seymour

  • Lipid-mediated enhancement of transfection by a nonviral integrin-targeting vector.

    S. L. Hart;C. V. Arancibia-Carcamo;M. A. Wolfert;C. Mailhos

  • Systemic circulation of poly(L-lysine)/DNA vectors is influenced by polycation molecular weight and type of DNA: differential circulation in mice and rats and the implications for human gene therapy.

    Christopher M. Ward;Martin L. Read;Leonard W. Seymour

  • Physical properties and in vitro transfection efficiency of gene delivery vectors based on complexes of DNA with synthetic polycations.

    Tomáš Reschel;Čestmı́r Koňák;David Oupický;David Oupický;Leonard W. Seymour

  • Decreased Binding to Proteins and Cells of Polymeric Gene Delivery Vectors Surface Modified with a Multivalent Hydrophilic Polymer and Retargeting through Attachment of Transferrin

    Philip R. Dash;Martin L. Read;Kerry D. Fisher;Kenneth A. Howard

  • Tumour tropism and anti-cancer efficacy of polymer-based doxorubicin prodrugs in the treatment of subcutaneous murine B16F10 melanoma.

    L. W. Seymour;K. Ulbrich;P. S. Steyger;M. Brereton

Frequent Co-Authors

Karel Ulbrich
Karel Ulbrich Czech Academy of Sciences
Etienne Schacht
Etienne Schacht Ghent University
Ruth Duncan
Ruth Duncan Cardiff University
David J. Kerr
David J. Kerr University of Oxford
Margreet A. Wolfert
Margreet A. Wolfert Utrecht University
Manfred Ogris
Manfred Ogris University of Vienna
Andrew Baird
Andrew Baird University of California, San Diego
Robert A. Seder
Robert A. Seder National Institute of Allergy and Infectious Diseases
Jindřich Kopeček
Jindřich Kopeček University of Utah
Martin Berry
Martin Berry University of Birmingham

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