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Hiroshi Maeda

Hiroshi Maeda

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Biology and Biochemistry
Japan
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
125
Citations
90050
World Ranking
498
National Ranking
20

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2025 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2023 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

Hiroshi Maeda is affiliated with Kumamoto University in Japan and specializes in research within materials science, biochemistry, genetics and molecular biology, and engineering. Their work primarily focuses on nanoparticle-based drug delivery, nanoplatforms for cancer theranostics, and fields related to molecular biology and biomedical engineering.

The scientist's publications cover a range of topics, with a significant emphasis on drug delivery systems and nanomedicine. Notable recent papers include:

  • Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancers, 2020, Advanced Drug Delivery Reviews
  • The 35th Anniversary of the Discovery of EPR Effect: A New Wave of Nanomedicines for Tumor-Targeted Drug Delivery-Personal Remarks and Future Prospects, 2021, Journal of Personalized Medicine
  • Polymer-conjugated glucosamine complexed with boric acid shows tumor-selective accumulation and simultaneous inhibition of glycolysis, 2020, Biomaterials
  • Fibrinolytic tissue plasminogen activator installed redox-active nanoparticles (t-PA@iRNP) for cancer therapy, 2020, Biomaterials
  • Phosphorylcholine-Grafted Molecular Bottlebrush-Doxorubicin Conjugates: High Structural Stability, Long Circulation in Blood, and Efficient Anticancer Activity, 2020, Biomacromolecules

Frequent coauthors who have contributed alongside Hiroshi Maeda include Jun Fang, Waliul Islam, Kazuo Sakurai, Ayaka Harada, and Takuro Niidome. The collaboration network shows repeated partnerships with these researchers, reflecting ongoing cooperative efforts in related areas.

The main publication venues for this researcher are:

  • Journal of Personalized Medicine
  • Biomaterials
  • Advanced Drug Delivery Reviews
  • Biomacromolecules
  • Cancers

Hiroshi Maeda's research fields span multiple sub-disciplines. These include biomaterials, biomedical engineering, molecular biology, materials chemistry, and pulmonary and respiratory medicine. The scientist's main topics center around:

  • Nanoparticle-Based Drug Delivery
  • Nanoplatforms for cancer theranostics
  • Lanthanide and Transition Metal Complexes
  • Heme Oxygenase-1 and Carbon Monoxide
  • Electron Spin Resonance Studies
  • Photodynamic Therapy Research Studies
  • Cancer, Hypoxia, and Metabolism

Best Publications

  • A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs

    Yasuhiro Matsumura;Hiroshi Maeda

  • Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.

    H Maeda;J Wu;T Sawa;Y Matsumura

  • A New High-TcOxide Superconductor without a Rare Earth Element

    Hiroshi Maeda;Yoshiaki Tanaka;Masao Fukutomi;Toshihisa Asano

  • The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect.

    Jun Fang;Hideaki Nakamura;Hiroshi Maeda

  • The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting.

    Hiroshi Maeda

  • The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo

    Hiroshi Maeda;Hideaki Nakamura;Jun Fang

  • Exploiting the enhanced permeability and retention effect for tumor targeting.

    Arun K. Iyer;Greish Khaled;Jun Fang;Hiroshi Maeda

  • Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

    Uma Prabhakar;Hiroshi Maeda;Rakesh K. Jain;Eva M. Sevick-Muraca

  • Genome sequencing and analysis of Aspergillus oryzae

    Masayuki Machida;Kiyoshi Asai;Motoaki Sano;Toshihiro Tanaka

  • Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect

    H. Maeda;G.Y. Bharate;J. Daruwalla

  • Tumor-selective delivery of macromolecular drugs via the EPR effect: background and future prospects.

    Hiroshi Maeda

  • Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS.

    Hiroshi Maeda;Tomohiro Sawa;Toshimitsu Konno

  • Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity

    Hiroshi Maeda

  • Sputter deposition of BiSrCaCuO thin films

    Masao Fukutomi;Junichi Machida;Yoshiaki Tanaka;Toshihisa Asano

  • Tumoritropic and lymphotropic principles of macromolecular drugs.

    Maeda H;Matsumura Y

  • Macromolecular therapeutics in cancer treatment: the EPR effect and beyond.

    Hiroshi Maeda

  • Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.NO through a radical reaction.

    Takaaki Akaike;Masaki Yoshida;Yoichi Miyamoto;Keizo Sato

  • Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo.

    Hiroshi Maeda;Len W. Seymour;Yoichi Miyamoto

  • Vascular permeability enhancement in solid tumor: various factors, mechanisms involved and its implications.

    Hiroshi Maeda;Jun Fang;Takao Inutsuka;Yasunori Kitamoto

  • Therapeutic strategies by modulating oxygen stress in cancer and inflammation.

    Jun Fang;Takahiro Seki;Hiroshi Maeda

Frequent Co-Authors

Takaaki Akaike
Takaaki Akaike Tohoku University
Kazumasa Togano
Kazumasa Togano National Institute for Materials Science
Hiroaki Kumakura
Hiroaki Kumakura National Institute for Materials Science
Nakao Ishida
Nakao Ishida Tohoku University
Hitoshi Kitaguchi
Hitoshi Kitaguchi National Institute for Materials Science
Peter Valent
Peter Valent Medical University of Vienna
Masaki Otagiri
Masaki Otagiri Sojo University
Masayuki Ando
Masayuki Ando Kumamoto University
Winfried F. Pickl
Winfried F. Pickl Medical University of Vienna
Karel Ulbrich
Karel Ulbrich Czech Academy of Sciences

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