Nobuhiro Nishiyama

Research.com Recognitions

• 2026 - Research.com Chemistry in Japan Leader Award
• 2025 - Research.com Chemistry in Japan Leader Award
• 2022 - Research.com Chemistry in Japan Leader Award

Overview

Best Publications

• Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

  H. Cabral;Y. Matsumoto;K. Mizuno;Q. Chen

  2572
  Citations

• Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery.

  Nobuhiro Nishiyama;Kazunori Kataoka

  1288
  Citations

• Novel Cisplatin-Incorporated Polymeric Micelles Can Eradicate Solid Tumors in Mice

  Nobuhiro Nishiyama;Souichiro Okazaki;Horacio Cabral;Masaki Miyamoto

  770
  Citations

• Lactosylated poly(ethylene glycol)-sIRNA conjugate through acid-labile β-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells

  Motoi Oishi;Yukio Nagasaki;Keiji Itaka;Nobuhiro Nishiyama

  714
  Citations

• Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy.

  Younsoo Bae;Nobuhiro Nishiyama;Shigeto Fukushima;Hiroyuki Koyama

  706
  Citations

• Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug delivery

  Younsoo Bae;Woo Dong Jang;Nobuhiro Nishiyama;Shigeto Fukushima

  544
  Citations

• A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy

  Peng Mi;Peng Mi;Daisuke Kokuryo;Horacio Cabral;Hailiang Wu

  519
  Citations

• Rational design of smart supramolecular assemblies for gene delivery: Chemical challenges in the creation of artificial viruses

  Kanjiro Miyata;Nobuhiro Nishiyama;Kazunori Kataoka

  513
  Citations

• Cyclic RGD-linked polymeric micelles for targeted delivery of platinum anticancer drugs to glioblastoma through the blood-brain tumor barrier

  Yutaka Miura;Tomoya Takenaka;Kazuko Toh;Shourong Wu

  507
  Citations

• Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-β signaling

  Mitsunobu R. Kano;Younsoo Bae;Caname Iwata;Yasuyuki Morishita

  486
  Citations

• Polyplexes from Poly(aspartamide) Bearing 1,2-Diaminoethane Side Chains Induce pH-Selective, Endosomal Membrane Destabilization with Amplified Transfection and Negligible Cytotoxicity

  Kanjiro Miyata;Makoto Oba;Masataka Nakanishi;Shigeto Fukushima

  483
  Citations

• Block catiomer polyplexes with regulated densities of charge and disulfide cross-linking directed to enhance gene expression.

  Kanjiro Miyata;Yoshinori Kakizawa;Nobuhiro Nishiyama;Atsushi Harada

  481
  Citations

• Cisplatin-incorporating polymeric micelles (NC-6004) can reduce nephrotoxicity and neurotoxicity of cisplatin in rats

  H Uchino;Y Matsumura;T Negishi;F Koizumi

  478
  Citations

• PEG-Detachable Polyplex Micelles Based on Disulfide-Linked Block Catiomers as Bioresponsive Nonviral Gene Vectors

  Seiji Takae;Kanjiro Miyata;Makoto Oba;Takehiko Ishii

  445
  Citations

• Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery.

  Yu Matsumoto;Joseph W. Nichols;Kazuko Toh;Takahiro Nomoto

  427
  Citations

• 3D spheroid culture system on micropatterned substrates for improved differentiation efficiency of multipotent mesenchymal stem cells

  Wenjie Wang;Keiji Itaka;Shinsuke Ohba;Nobuhiro Nishiyama

  417
  Citations

• Light-induced gene transfer from packaged DNA enveloped in a dendrimeric photosensitizer

  Nobuhiro Nishiyama;Aya Iriyama;Woo Dong Jang;Kanjiro Miyata

  404
  Citations

• Charge‐Conversional Polyionic Complex Micelles—Efficient Nanocarriers for Protein Delivery into Cytoplasm

  Yan Lee;Takehiko Ishii;Horacio Cabral;Hyun Jin Kim

  370
  Citations

• Preparation and Characterization of Self-Assembled Polymer−Metal Complex Micelle from cis-Dichlorodiammineplatinum(II) and Poly(ethylene glycol)−Poly(α,β-aspartic acid) Block Copolymer in an Aqueous Medium

  Nobuhiro Nishiyama;Masayuki Yokoyama;Takao Aoyagi;Teruo Okano

  364
  Citations

• Environment-responsive block copolymer micelles with a disulfide cross-linked core for enhanced siRNA delivery.

  Satoru Matsumoto;R. James Christie;Nobuhiro Nishiyama;Kanjiro Miyata

  364
  Citations