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Immunology
USA
2026

D-Index & Metrics

Immunology

D-Index
149
Citations
117599
World Ranking
123
National Ranking
80

Medicine

D-Index
149
Citations
117725
World Ranking
1177
National Ranking
684

Research.com Recognitions

  • 2026 - Research.com Immunology in United States Leader Award
  • 2025 - Research.com Immunology in United States Leader Award
  • 2017 - Warren Alpert Foundation Prize For their collective contributions to the pre-clinical foundation and development of immune checkpoint blockade, a novel form of cancer therapy that has transformed the landscape of cancer treatment.
  • 2016 - AAI-Steinman Award for Human Immunology Research, American Association of Immunologists

Overview

Lieping Chen is affiliated with Yale University in the United States. Their research primarily spans the field of medicine, with a specific focus on oncology, immunology, pulmonary and respiratory medicine, molecular biology, and surgery. Chen's work concentrates on topics related to cancer immunotherapy, immune responses, and cell interactions within the immune system.

The main topics explored in Chen's research include:

  • Cancer Immunotherapy and Biomarkers
  • Immunotherapy and Immune Responses
  • CAR-T Cell Therapy Research
  • Immune Cell Function and Interaction
  • Immune Cells in Cancer
  • Lung Cancer Treatments and Mutations
  • Glioma Diagnosis and Treatment

Chen has published extensively in several venues, with the most frequent publication outlets being:

  • IEEE Transactions on Systems Man and Cybernetics Systems
  • Journal of Thoracic Oncology
  • Journal of Investigative Dermatology
  • PubMed
  • Scientific Reports

Recent notable publications by Chen include:

  • Resistance Mechanisms to Anti-PD Cancer Immunotherapy, 2022, Annual Review of Immunology
  • Adaptive Immune Resistance at the Tumour Site: Mechanisms and Therapeutic Opportunities, 2022, Nature Reviews Drug Discovery
  • Phase I Study of Single-Agent Anti-Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates, 2023, Journal of Clinical Oncology
  • A Burned-Out CD8+ T-cell Subset Expands in the Tumor Microenvironment and Curbs Cancer Immunotherapy, 2021, Cancer Discovery
  • Blockade of the CD93 Pathway Normalizes Tumor Vasculature to Facilitate Drug Delivery and Immunotherapy, 2021, Science Translational Medicine

Frequent co-authors in Chen's research include:

  • Enrique Herrera-Viedma
  • Sam Kwong
  • Karen Panetta
  • Giancarlo Fortino
  • Róbert Kozma

Chen's contributions have been recognized by awards including the Warren Alpert Foundation Prize in 2017, awarded for collective contributions to the development of immune checkpoint blockade therapies in cancer treatment. In 2016, Chen also received the AAI-Steinman Award for Human Immunology Research from the American Association of Immunologists.

Best Publications

  • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.

    Suzanne L. Topalian;F. Stephen Hodi;Julie R. Brahmer;Scott N. Gettinger

  • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival.

    Tyler J Curiel;George Coukos;Linhua Zou;Xavier Alvarez

  • Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion

    Haidong Dong;Scott E. Strome;Diva R. Salomao;Hideto Tamura

  • Molecular mechanisms of T cell co-stimulation and co-inhibition

    Lieping Chen;Dallas B. Flies;Dallas B. Flies

  • Phase I Study of Single-Agent Anti–Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates

    Julie R. Brahmer;Charles G. Drake;Ira Wollner;John D. Powderly

  • B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

    Haidong Dong;Gefeng Zhu;Koji Tamada;Lieping Chen

  • Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy

    Janis M Taube;Alison P. Klein;Julie R Brahmer;Haiying Xu

  • PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations

    Weiping Zou;Jedd D. Wolchok;Lieping Chen

  • Colocalization of Inflammatory Response with B7-H1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune Escape

    Janis M. Taube;Robert A. Anders;Geoffrey D. Young;Haiying Xu

  • Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

    Unknown

  • Inhibitory B7-family molecules in the tumour microenvironment

    Weiping Zou;Lieping Chen

  • Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity.

    Lieping Chen

  • A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization

    Miguel Fernández de Sanmamed;Lieping Chen

  • Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity.

    Tyler J Curiel;Shuang Wei;Haidong Dong;Xavier Alvarez

  • Anti–PD-1/PD-L1 therapy of human cancer: past, present, and future

    Lieping Chen;Xue Han

  • Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

    Lieping Chen;Stephanie Ashe;William A. Brady;Ingegerd Hellström

  • B7-H3: A costimulatory molecule for T cell activation and IFN-γ production

    Andrei I. Chapoval;Jian Ni;Julie S. Lau;Ryan A. Wilcox

  • Blockade of B7-H1 and PD-1 by Monoclonal Antibodies Potentiates Cancer Therapeutic Immunity

    Fumiya Hirano;Katsumi Kaneko;Hideto Tamura;Haidong Dong

  • Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

    Ignacio Melero;Walter W. Shuford;Stephanie Ashe Newby;Alejandro Aruffo

  • Costimulatory b7-h1 in renal cell carcinoma patients: indicator of tumor aggressiveness and potential therapeutic target

    Lieping Chen;Scott E. Strome;Eugene D. Kwon

  • Erratum: Molecular mechanisms of T cell co-stimulation and co-inhibition

    Lieping Chen;Dallas B. Flies

Frequent Co-Authors

Koji Tamada
Koji Tamada Yamaguchi University
Haidong Dong
Haidong Dong Mayo Clinic
Karl Erik Hellström
Karl Erik Hellström University of Washington
Kurt A. Schalper
Kurt A. Schalper Yale University
David L. Rimm
David L. Rimm Yale University
Roy S. Herbst
Roy S. Herbst Yale University
Ignacio Melero
Ignacio Melero University of Oxford
Weiping Zou
Weiping Zou University of Michigan–Ann Arbor
Ingegerd Hellström
Ingegerd Hellström University of Washington
Drew M. Pardoll
Drew M. Pardoll Johns Hopkins University School of Medicine

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