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D-Index & Metrics

Biology and Biochemistry

D-Index
51
Citations
7731
World Ranking
17328
National Ranking
422

Overview

Jan G. M. Bolscher is affiliated with the Academic Center for Dentistry Amsterdam in the Netherlands. Their research spans multiple disciplines within the life sciences, focusing primarily on biochemistry, genetics, molecular biology, immunology, microbiology, and medicine.

The scientist's work covers several key subfields including microbiology, molecular biology, nutrition and dietetics, physiology, and cell biology. Their main research topics encompass antimicrobial peptides and activities, infant nutrition and health, RNA interference and gene delivery, salivary gland disorders and functions, silk-based biomaterials and applications, sinusitis and nasal conditions, as well as pediatric health and respiratory diseases.

Frequently publishing in journals such as Biochemistry and Cell Biology, BioMetals, PLoS ONE, Cells, and the Journal of Tissue Engineering and Regenerative Medicine, Jan G. M. Bolscher contributes extensively to peer-reviewed scientific literature. Regular collaborators include Kamran Nazmi, Floris J. Bikker, Adrián Canizalez-Román, Nidia León-Sicairos, and Enno C.I. Veerman.

Selected recent papers highlight diverse areas of investigation, reflecting the scientist's interdisciplinary approach:

  • Antitumor activity of bovine lactoferrin and its derived peptides against HepG2 liver cancer cells and Jurkat leukemia cells, 2023, BioMetals
  • D-LL-31 enhances biofilm-eradicating effect of currently used antibiotics for chronic rhinosinusitis and its immunomodulatory activity on human lung epithelial cells, 2020, PLoS ONE
  • All-trans retinoic acid and human salivary histatin-1 promote the spreading and osteogenic activities of pre-osteoblasts in vitro, 2020, FEBS Open Bio
  • Salivary Histatin 1 and 2 Are Targeted to Mitochondria and Endoplasmic Reticulum in Human Cells, 2020, Cells
  • Histatin-1 is a novel osteogenic factor that promotes bone cell adhesion, migration, and differentiation, 2021, Journal of Tissue Engineering and Regenerative Medicine

Best Publications

  • Lactoferrampin: a novel antimicrobial peptide in the N1-domain of bovine lactoferrin.

    Marieke I.A van der Kraan;Jasper Groenink;Kamran Nazmi;Enno C.I Veerman

  • Histatins are the major wound-closure stimulating factors in human saliva as identified in a cell culture assay

    Menno J. Oudhoff;Jan G. M. Bolscher;Kamran Nazmi;Hakan Kalay

  • Identification of the Bacteria-binding Peptide Domain on Salivary Agglutinin (gp-340/DMBT1), a Member of the Scavenger Receptor Cysteine-rich Superfamily*

    Floris J. Bikker;Antoon J. M. Ligtenberg;Kamran Nazmi;Enno C. I. Veerman

  • Candidacidal effects of two antimicrobial peptides: histatin 5 causes small membrane defects, but LL-37 causes massive disruption of the cell membrane.

    Alice L. den Hertog;Jan van Marle;Henk A. van Veen;Wim van't Hof

  • Glycan-modified liposomes boost CD4+ and CD8+ T-cell responses by targeting DC-SIGN on dendritic cells

    Wendy W.J. Unger;Astrid J. van Beelen;Sven C. Bruijns;Medha Joshi

  • Sulfomucins in the human body.

    A. V. Nieuw Amerongen;J. G. M. Bolscher;E. Bloemena;E. C. I. Veerman

  • Multivalent glycopeptide dendrimers for the targeted delivery of antigens to dendritic cells.

    Juan J. García-Vallejo;Martino Ambrosini;Annemieke Overbeek;Wilhelmina E. van Riel

  • Bactericidal activity of LFchimera is stronger and less sensitive to ionic strength than its constituent lactoferricin and lactoferrampin peptides.

    Jan G.M. Bolscher;Regina Adão;Kamran Nazmi;Petra A.M. van den Keybus

  • Enzymatic amplification involving glycosyltransferases forms the basis for the increased size of asparagine-linked glycans at the surface of NIH 3T3 cells expressing the N-ras proto-oncogene.

    E. W. Easton;J. G. M. Bolscher;D. H. Van Den Eijnden

  • CNS myelin induces regulatory functions of DC-SIGN-expressing, antigen-presenting cells via cognate interaction with MOG

    J. J. Garcia-Vallejo;J. M. Ilarregui;H. Kalay;S. Chamorro

  • Sortase A as a tool for high-yield histatin cyclization

    Jan G. M. Bolscher;Menno J. Oudhoff;Kamran Nazmi;John M. Antos

  • Energy Depletion Protects Candida albicans against Antimicrobial Peptides by Rigidifying Its Cell Membrane

    Enno C. I. Veerman;Marianne Valentijn-Benz;Kamran Nazmi;Anita L. A. Ruissen

  • Structure-activity analysis of histatin, a potent wound healing peptide from human saliva: cyclization of histatin potentiates molar activity 1000-fold

    Menno J. Oudhoff;Kim L. Kroeze;Kamran Nazmi;Petra A. M. van den Keijbus

  • Ultrastructural effects of antimicrobial peptides from bovine lactoferrin on the membranes of Candida albicans and Escherichia coli.

    Marieke I.A. van der Kraan;Jan van Marle;Kamran Nazmi;Jasper Groenink

  • Novel lactoferrampin antimicrobial peptides derived from human lactoferrin.

    Evan F. Haney;Kamran Nazmi;Fanny Lau;Jan G.M. Bolscher

  • Chemical modification of the glucosidase inhibitor 1-deoxynojirimycin. Structure-activity relationships.

    A Tan;L van den Broek;S van Boeckel;H Ploegh

  • Lactoferrampin, an antimicrobial peptide of bovine lactoferrin, exerts its candidacidal activity by a cluster of positively charged residues at the C-terminus in combination with a helix-facilitating N-terminal part

    Marieke I A van der Kraan;Kamran Nazmi;Afke Teeken;Jasper Groenink

  • Reactive oxygen species play no role in the candidacidal activity of the salivary antimicrobial peptide histatin 5

    Enno C. I. Veerman;Kamran Nazmi;Wim van 't Hof;Jan G. M. Bolscher

  • A monoclonal antibody directed against high M(r) salivary mucins recognizes the SO3-3Gal beta 1-3GlcNAc moiety of sulfo-Lewis(a): a histochemical survey of human and rat tissue

    E. C. I. Veerman;J. G. M. Bolscher;B. J. Appelmelk;E. Bloemena

  • Interactions of histatin 5 and histatin 5-derived peptides with liposome membranes: surface effects, translocation and permeabilization

    Alice L Den Hertog;Harro W Wong Fong Sang;Ruud Kraayenhof;Jan G M Bolscher

Frequent Co-Authors

Enno C. I. Veerman
Enno C. I. Veerman Academic Center for Dentistry Amsterdam
Arie V. Nieuw Amerongen
Arie V. Nieuw Amerongen Academic Center for Dentistry Amsterdam
Susan Gibbs
Susan Gibbs Vrije Universiteit Amsterdam
David T.W. Wong
David T.W. Wong University of California, Los Angeles
David Elashoff
David Elashoff University of California, Los Angeles
Juan J. Garcia-Vallejo
Juan J. Garcia-Vallejo University of Amsterdam
C. René Leemans
C. René Leemans University of Amsterdam
Bastiaan P. Krom
Bastiaan P. Krom Academic Center for Dentistry Amsterdam
Bauke Ylstra
Bauke Ylstra Vrije Universiteit Amsterdam
Annemarie Poustka
Annemarie Poustka German Cancer Research Center

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