World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
96
Citations
34445
World Ranking
9645
National Ranking
374

Overview

C. René Leemans is affiliated with the University of Amsterdam in the Netherlands and specializes primarily in the field of Medicine, with a particular focus on Oncology. Their work spans several subfields including Otorhinolaryngology, Surgery, Pulmonary and Respiratory Medicine, and Radiology, Nuclear Medicine and Imaging. Over the course of their research career, the scientist has contributed to a broad range of cancer-related studies, with a notable emphasis on head and neck cancer.

The scientist's main research topics include:

  • Head and Neck Cancer Studies
  • Cancer survivorship and care
  • Radiomics and Machine Learning in Medical Imaging
  • Cancer Immunotherapy and Biomarkers
  • Head and Neck Surgical Oncology
  • Esophageal Cancer Research and Treatment
  • Cancer-related molecular mechanisms research

Their recent publications reflect this specialization, with works addressing clinical practice, diagnostics, and prognostic studies. Selected recent papers include:

  • "Head and neck squamous cell carcinoma," 2020, published in Nature Reviews Disease Primers
  • "Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up," 2020, published in Annals of Oncology
  • "Prognostic implications of p16 and HPV discordance in oropharyngeal cancer (HNCIG-EPIC-OPC): a multicentre, multinational, individual patient data analysis," 2023, published in The Lancet Oncology
  • "European white paper: oropharyngeal dysphagia in head and neck cancer," 2020, published in European Archives of Oto-Rhino-Laryngology
  • "Recommendations for head and neck surgical oncology practice in a setting of acute severe resource constraint during the COVID-19 pandemic: an international consensus," 2020, published in The Lancet Oncology

Frequent co-authors collaborating with this scientist include:

  • Ruud H. Brakenhoff
  • Irma M. Verdonck-de Leeuw
  • Femke Jansen
  • Robert P. Takes
  • Birgit I. Lissenberg-Witte

The scientist has published extensively in several academic journals, with repeated contributions to the following venues:

  • Oral Oncology
  • Supportive Care in Cancer
  • Cancers
  • Head & Neck
  • Radiotherapy and Oncology

Best Publications

  • Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach

    Hugo J W L Aerts;Emmanuel Rios Velazquez;Ralph T H Leijenaar;Chintan Parmar

  • The molecular landscape of head and neck cancer

    C. René Leemans;Peter J. F. Snijders;Ruud H. Brakenhoff

  • Prevalence of depression in cancer patients: a meta‐analysis of diagnostic interviews and self‐report instruments

    A M H Krebber;L M Buffart;G Kleijn;I C Riepma

  • Impact of Late Treatment-Related Toxicity on Quality of Life Among Patients With Head and Neck Cancer Treated With Radiotherapy

    Johannes A. Langendijk;Patricia Doornaert;Irma M. Verdonck-de Leeuw;Charles R. Leemans

  • A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen.

    Serge J. Smeets;Albertus T. Hesselink;Ernst Jan M. Speel;Annick Haesevoets

  • Regional lymph node involvement and its significance in the development of distant metastases in head and neck carcinoma.

    Charles R. Leemans;Rammohan Tiwari;J. P. Jos Nauta;Isaac Van der Waal

  • Recurrence at the primary site in head and neck cancer and the significance of neck lymph node metastases as a prognostic factor

    Charles R. Leemans;Rammohan Tiwari;Jos J. P. Nauta;Isaac Van Der Waal

  • The Mutational Landscape of Adenoid Cystic Carcinoma

    Allen S Ho;Kasthuri Kannan;David M Roy;Luc G T Morris

  • Intensity-modulated radiotherapy reduces radiation-induced morbidity and improves health-related quality of life: results of a nonrandomized prospective study using a standardized follow-up program.

    Marije R. Vergeer;Patricia A. H. Doornaert;Derek H. F. Rietveld;C. Rene Leemans

  • Screening for Distant Metastases in Patients With Head and Neck Cancer

    R de Bree;E E Deurloo;G B Snow;C R Leemans

  • Phase 3 Randomized Trial on Larynx Preservation Comparing Sequential vs Alternating Chemotherapy and Radiotherapy

    J.L. Lefebvre;F. Rolland;M. Tesselaar;E. Bardet

  • A phase I dose escalation study with anti-CD44v6 bivatuzumab mertansine in patients with incurable squamous cell carcinoma of the head and neck or esophagus

    Bernard M. Tijink;Jan Buter;Remco de Bree;Giuseppe Giaccone

  • Peripheral blood IFN-gamma-secreting Valpha24+Vbeta11+ NKT cell numbers are decreased in cancer patients independent of tumor type or tumor load.

    Johan W Molling;Wendy Kölgen;Hans J J van der Vliet;Martijn F Boomsma

  • Predictive modelling for swallowing dysfunction after primary (chemo)radiation: Results of a prospective observational study

    Miranda E.M.C. Christianen;Cornelis Schilstra;Ivo Beetz;Christina T. Muijs

  • Genome-wide DNA copy number alterations in head and neck squamous cell carcinomas with or without oncogene-expressing human papillomavirus

    S J Smeets;B J M Braakhuis;S Abbas;P J F Snijders

  • Effect of nutritional interventions on nutritional status, quality of life and mortality in patients with head and neck cancer receiving (chemo) radiotherapy: a systematic review

    Jacqueline A.E. Langius;Myrna C. Zandbergen;Simone E.J. Eerenstein;Maurits W. van Tulder

  • Critical weight loss is a major prognostic indicator for disease-specific survival in patients with head and neck cancer receiving radiotherapy.

    J. A. E. Langius;S. Bakker;D. H. F. Rietveld;H. M. Kruizenga

  • Impact of radiation-induced xerostomia on quality of life after primary radiotherapy among patients with head and neck cancer.

    Anke Petra Jellema;Anke Petra Jellema;Ben J. Slotman;Patricia Doornaert;C. René Leemans

  • Global incidence of oral and oropharynx cancer in patients younger than 45 years versus older patients: A systematic review.

    Aisha A. Hussein;Marco N. Helder;Jan G. de Visscher;C. René Leemans

  • A genetic progression model of oral cancer: current evidence and clinical implications.

    Boudewijn J. M. Braakhuis;C. René Leemans;Ruud H. Brakenhoff

Frequent Co-Authors

Remco de Bree
Remco de Bree Utrecht University
Johannes A. Langendijk
Johannes A. Langendijk University Medical Center Groningen
Otto S. Hoekstra
Otto S. Hoekstra Amsterdam UMC
Ben J. Slotman
Ben J. Slotman University of Amsterdam
Alessandra Rinaldo
Alessandra Rinaldo University of Udine
Peter J.F. Snijders
Peter J.F. Snijders Vrije Universiteit Amsterdam
Alfio Ferlito
Alfio Ferlito University of Udine
Pim Cuijpers
Pim Cuijpers Vrije Universiteit Amsterdam
Gordon B. Snow
Gordon B. Snow Amsterdam UMC
Ashok R. Shaha
Ashok R. Shaha Memorial Sloan Kettering Cancer Center

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