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Immunology

D-Index
64
Citations
10954
World Ranking
2971
National Ranking
110

Overview

Bert A. 't Hart is affiliated with the University of Amsterdam in the Netherlands. Their research primarily focuses on the fields of Medicine and Biochemistry, Genetics, and Molecular Biology, with significant contributions to subfields including Pathology and Forensic Medicine, Biophysics, Developmental Neuroscience, Immunology, and Molecular Biology.

The scientist's main topics of study center around Multiple Sclerosis research, with additional focus areas such as neurogenesis and neuroplasticity mechanisms, peripheral neuropathies and disorders, immune response and inflammation, gut microbiota and health, neuroinflammation and neurodegeneration mechanisms, and cytokine signaling pathways and interactions.

Among recent publications, the following notable papers demonstrate the scope of their research:

  • "Enhanced axonal response of mitochondria to demyelination offers neuroprotection: implications for multiple sclerosis," 2020, Acta Neuropathologica
  • "Bacterial Peptidoglycan as a Driver of Chronic Brain Inflammation," 2020, Trends in Molecular Medicine
  • "Multiple sclerosis is linked to MAPKERK overactivity in microglia," 2021, Journal of Molecular Medicine
  • "Mechanistic underpinning of an inside-out concept for autoimmunity in multiple sclerosis," 2021, Annals of Clinical and Translational Neurology
  • "Multiple sclerosis and drug discovery: A work of translation," 2021, EBioMedicine

Frequent collaborators have included:

  • Antonio Luchicchi
  • Geert J. Schenk
  • Jon D. Laman
  • Moses Rodriguez
  • Jeroen Geurts

Publication venues consistently featuring their work include:

  • Acta Neuropathologica
  • Annals of Clinical and Translational Neurology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Preprints.org
  • Trends in Molecular Medicine

Bert A. 't Hart's research outputs integrally address various aspects of neuroimmunology and neuropathology, particularly related to autoimmune mechanisms and neurodegenerative processes in multiple sclerosis. The multidisciplinary and collaborative nature of their work is reflected in the variety of coauthors and specialized journals publishing their findings.

Best Publications

  • SELF- AND NONSELF-RECOGNITION BY C-TYPE LECTINS ON DENDRITIC CELLS

    Teunis B H Geijtenbeek;Sandra J van Vliet;Anneke Engering;Bert A 't Hart

  • Why primate models matter

    Kimberley A. Phillips;Karen L. Bales;Karen L. Bales;John P. Capitanio;John P. Capitanio;Alan Conley

  • Asymptomatic synovitis precedes clinically manifest arthritis

    Maarten C. Kraan;Hans Versendaal;Margreet Jonker;Barry Bresnihan

  • Transfer of Central Nervous System Autoantigens and Presentation in Secondary Lymphoid Organs

    Alex F. de Vos;Marjan van Meurs;Herbert P. Brok;Leonie A. Boven

  • Human neural stem cells ameliorate autoimmune encephalomyelitis in non-human primates

    Stefano Pluchino;Angela Gritti;Erwin Blezer;Stefano Amadio

  • Reactive oxygen species are involved in the pathogenesis of experimental allergic encephalomyelitis in Lewis rats.

    Sigrid R. Ruuls;Jan Bauer;Karin Sontrop;Ingeborg Huitinga

  • Metabolic activation of natural phenols into selective oxidative burst agonists by activated human neutrophils

    Unknown

  • Prevention of Experimental Autoimmune Encephalomyelitis in the Common Marmoset (Callithrix jacchus) Using a Chimeric Antagonist Monoclonal Antibody Against Human CD40 Is Associated with Altered B Cell Responses

    L Boon;H P Brok;J Bauer;A Ortiz-Buijsse

  • The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis

    Maarten Van Roy;Cedric Ververken;Els Beirnaert;Sven Hoefman

  • Antiarthritic activity of the newly developed neutrophil oxidative burst antagonist apocynin

    Bert A. 'T Hart;Jos M. Simons;Knaan-Shanzer Shoshan;Nicolaas P.M. Bakker

  • EAE : imperfect but useful models of multiple sclerosis

    Bert A. ’t Hart;Bruno Gran;Robert Weissert

  • Prevention of experimental autoimmune encephalomyelitis in common marmosets using an anti-IL-12p40 monoclonal antibody.

    Herbert P. M. Brok;Marjan van Meurs;Erwin Blezer;Allen Schantz

  • Surgical excision of CNS-draining lymph nodes reduces relapse severity in chronic-relapsing experimental autoimmune encephalomyelitis

    Marloes van Zwam;Ruth Huizinga;Ruth Huizinga;Nicole Heijmans;Marjan van Meurs

  • Myelin/Oligodendrocyte Glycoprotein-Induced Autoimmune Encephalomyelitis in Common Marmosets: The Encephalitogenic T Cell Epitope pMOG24–36 Is Presented by a Monomorphic MHC Class II Molecule

    Herbert P.M. Brok;Antonio Uccelli;Nicole Kerlero de Rosbo;Ronald E. Bontrop

  • Brain antigens in functionally distinct antigen-presenting cell populations in cervical lymph nodes in MS and EAE

    Marloes van Zwam;Ruth Huizinga;Ruth Huizinga;Marie-José Melief;Annet F. Wierenga-Wolf

  • Animal models for arthritis: innovative tools for prevention and treatment

    G. Kollias;P. Papadaki;F. Apparailly;M.J. Vervoordeldonk

  • Effects of apocynin, a drug isolated from the roots of Picrorhiza kurroa, on arachidonic acid metabolism

    Ferdi Engels;Bastien F. Renirie;Bert A. 't Hart;Rudi P. Labadie

  • TLR Triggering on Tolerogenic Dendritic Cells Results in TLR2 Up-Regulation and a Reduced Proinflammatory Immune Program

    Sonia Chamorro;Juan J. García-Vallejo;Wendy W. J. Unger;Rosette J. Fernandes

  • The marmoset monkey: a multi-purpose preclinical and translational model of human biology and disease

    Bert A. ’t Hart;David H. Abbott;Katsuki Nakamura;Eberhard Fuchs

  • Expression of accessory molecules and cytokines in acute EAE in marmoset monkeys (Callithrix jacchus)

    Jon D Laman;Marjan van Meurs;Marc M Schellekens;Mark de Boer

  • CNS myelin induces regulatory functions of DC-SIGN-expressing, antigen-presenting cells via cognate interaction with MOG

    J. J. Garcia-Vallejo;J. M. Ilarregui;H. Kalay;S. Chamorro

  • Modelling of multiple sclerosis: lessons learned in a non-human primate

    Bert A 't Hart;Jon D Laman;Jan Bauer;Erwin Blezer

Frequent Co-Authors

Jon D. Laman
Jon D. Laman University Medical Center Groningen
Jan Bauer
Jan Bauer Medical University of Vienna
Bruno Gran
Bruno Gran University of Nottingham
Sandra Amor
Sandra Amor University of Amsterdam
Ronald E. Bontrop
Ronald E. Bontrop Utrecht University
Louis Boon
Louis Boon University of Amsterdam
Robert Weissert
Robert Weissert University of Regensburg
Yvette van Kooyk
Yvette van Kooyk Vrije Universiteit Amsterdam
David Baker
David Baker University of Washington
Bart J. L. Eggen
Bart J. L. Eggen University Medical Center Groningen

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Related Online Degrees & Career Pathways

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Each pathway offers unique advantages depending on your career goals and background, helping to bridge the gap between immunology theory and hands-on patient care or research.

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