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Best Scientists
2025
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Biology and Biochemistry
Canada
2026

D-Index & Metrics

Best Scientists

D-Index
206
Citations
172880
World Ranking
235
National Ranking
6

Biology and Biochemistry

D-Index
209
Citations
178850
World Ranking
26
National Ranking
1

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Canada Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Biology and Biochemistry in Canada Leader Award
  • 2023 - Research.com Biology and Biochemistry in Canada Leader Award
  • 2022 - Research.com Biology and Biochemistry in Canada Leader Award
  • 2021 - Szent-Györgyi Prize for Progress in Cancer Research, National Foundation for Cancer Research (NFCR)
  • 2004 - Paul Ehrlich and Ludwig Darmstaedter Prize
  • 1996 - Alfred P. Sloan Jr. Prize, General Motors Cancer Research Foundation
  • 1996 - Robert L. Noble Prize, Canadian Cancer Society
  • 1995 - King Faisal Prize
  • 1989 - Canada Gairdner International Award

Overview

Tak W. Mak is affiliated with the Princess Margaret Cancer Centre in Canada and has a research focus spanning biochemistry, genetics, molecular biology, and medicine. Their scholarly contributions include an extensive body of work within these fields, with specific emphasis on molecular biology, immunology, oncology, genetics, and cancer research.

Their research addresses several main topics, including:

  • Glioma Diagnosis and Treatment
  • Immune Cell Function and Interaction
  • Microtubule and mitosis dynamics
  • Epigenetics and DNA Methylation
  • Acute Myeloid Leukemia Research
  • Immune cells in cancer
  • DNA Repair Mechanisms

Tak W. Mak has published frequently in scientific journals recognized within the biomedical research community. Their most common publication venues include:

  • Cell Death and Differentiation
  • Cancer Research
  • Proceedings of the National Academy of Sciences
  • Neuro-Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)

Among the recent publications linked to their area of activity are several papers notable for citation impact and topical relevance, including:

  • "Beyond immune checkpoint blockade: emerging immunological strategies," 2021, Nature Reviews Drug Discovery
  • "Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles," 2022, Science Immunology
  • "An aberrant STAT pathway is central to COVID-19," 2020, Cell Death and Differentiation
  • "Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function," 2020, Cell Metabolism
  • "Tumour predisposition and cancer syndromes as models to study gene-environment interactions," 2020, Nature reviews. Cancer

Collaborative efforts feature prominently in Tak W. Mak's research profile, with frequent co-authors including:

  • Jérôme Fortin, with 20 joint publications
  • Andrew Wakeham, with 18 joint publications
  • Mark R. Bray, with 18 joint publications
  • David W. Cescon, with 13 joint publications
  • Jillian Haight, with 12 joint publications

Throughout their career, Tak W. Mak has been recognized with multiple scientific awards, including:

  • Szent-Györgyi Prize for Progress in Cancer Research, National Foundation for Cancer Research (NFCR), 2021
  • Paul Ehrlich and Ludwig Darmstaedter Prize, 2004
  • Robert L. Noble Prize, Canadian Cancer Society, 1996
  • Alfred P. Sloan Jr. Prize, General Motors Cancer Research Foundation, 1996
  • King Faisal Prize, 1995
  • Canada Gairdner International Award, 1989

Best Publications

  • OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

    Young-Yun Kong;Hiroki Yoshida;Ildiko Sarosi;Hong-Lin Tan

  • Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4

    Paul Waterhouse;Josef M. Penninger;Emma Timms;Andrew Wakeham

  • Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

    Vuk Stambolic;Vuk Stambolic;Akira Suzuki;Akira Suzuki;José Luis de la Pompa;José Luis de la Pompa

  • Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

    Takeshi Takahashi;Tomoyuki Tagami;Sayuri Yamazaki;Toshimitsu Uede

  • Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts.

    Hiroshi Takayanagi;Sunhwa Kim;Takako Koga;Takako Koga;Hiroshi Nishina

  • Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

    Nicholas Joza;Nicholas Joza;Santos A. Susin;Eric Daugas;William L. Stanford

  • DNA damage-induced activation of p53 by the checkpoint kinase Chk2.

    Atsushi Hirao;Young-Yun Kong;Shuhei Matsuoka;Andrew Wakeham

  • Differential T cell costimulatory requirements in CD28-deficient mice

    Arda Shahinian;Klaus Pfeffer;Kelvin P. Lee;Thomas M. Kündig

  • Differential requirement for caspase 9 in apoptotic pathways in vivo

    Razqallah Hakem;Razqallah Hakem;Anne Hakem;Anne Hakem;Gordon S Duncan;Gordon S Duncan;Jeffrey T Henderson

  • An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid.

    Mathias Chamaillard;Masahito Hashimoto;Yasuo Horie;Junya Masumoto

  • A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains

    Yusuke Yanagi;Yasunobu Yoshikai;Kathleen Leggett;Stephen P. Clark

  • TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

    Mark A. Lomaga;Wen Chen Yeh;Ildiko Sarosi;Gordon S. Duncan

  • Apaf1 is required for mitochondrial pathways of apoptosis and brain development.

    Hiroki Yoshida;Hiroki Yoshida;Young-Yun Kong;Young-Yun Kong;Ritsuko Yoshida;Ritsuko Yoshida;Andrew J Elia;Andrew J Elia

  • Profound block in thymocyte development in mice lacking p56lck.

    T. J. Molina;K. Kishihara;D. P. Siderovskid;W. van Ewijk

  • Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

    Keisuke Ito;Atsushi Hirao;Fumio Arai;Sahoko Matsuoka

  • Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration

    Takehiko Sasaki;Junko Irie-Sasaki;Junko Irie-Sasaki;Russell G. Jones;Antonio J. Oliveira-dos-Santos

  • Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors

    Akinori Takaoka;Hideyuki Yanai;Seiji Kondo;Gordon Duncan

  • Regulation of PTEN transcription by p53.

    V. Stambolic;D. MacPherson;D. Sas;Y. Lin

  • FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis

    Wen-Chen Yeh;José Luis de la Pompa;Mila E. McCurrach;Hong-Bing Shu

  • Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes

    Minna Woo;Razqallah Hakem;Maria S. Soengas;Gordon S. Duncan

Frequent Co-Authors

Andrew Wakeham
Andrew Wakeham Princess Margaret Cancer Centre
Gordon S. Duncan
Gordon S. Duncan University Health Network
Pamela S. Ohashi
Pamela S. Ohashi Princess Margaret Cancer Centre
Josef M. Penninger
Josef M. Penninger University of British Columbia
Akira Suzuki
Akira Suzuki Kobe University
Andrew J. Elia
Andrew J. Elia Princess Margaret Cancer Centre
Vuk Stambolic
Vuk Stambolic University of Toronto
Takehiko Sasaki
Takehiko Sasaki Tokyo Medical and Dental University
Gerry Melino
Gerry Melino University of Rome Tor Vergata
Razqallah Hakem
Razqallah Hakem University of Toronto

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