World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
52
Citations
21580
World Ranking
16430
National Ranking
573

Overview

Gordon S. Duncan is affiliated with the University Health Network in Canada. Their research spans several interconnected fields, primarily focusing on immunology and microbiology, medicine, and biochemistry, genetics, and molecular biology. The scientist's work covers subfields including immunology, molecular biology, oncology, hematology, and biochemistry.

Their published output includes multiple research articles appearing in recognized scientific venues. Key recent papers include:

  • Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function, 2020, Cell Metabolism
  • IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interaction with the AITL microenvironment, 2023, Cancer Cell
  • Cholinergic control of Th17 cell pathogenicity in experimental autoimmune encephalomyelitis, 2022, Cell Death and Differentiation
  • Reply to: Questioning whether the IgM Fc receptor (FcμR) is expressed by innate immune cells, 2022, Nature Communications
  • Mutant IDH1 cooperates with NPM1c or FLT3 ITD to drive distinct myeloid diseases and molecular outcomes, 2025, Proceedings of the National Academy of Sciences

They have contributed to research topics including immunotherapy and immune responses, T-cell and B-cell immunology, epigenetics and DNA methylation, amino acid enzymes and metabolism, mast cells and histamine, lymphoma diagnosis and treatment, and vascular tumors and angiosarcomas.

Frequent coauthors collaborating with Gordon S. Duncan include Tak W. Mak, Jillian Haight, Parameswaran Ramachandran, Julie Leca, and François Lemonnier.

The scientist's publications have appeared repeatedly in venues such as Cell Metabolism, Cancer Cell, Cell Death and Differentiation, Proceedings of the National Academy of Sciences, and Nature Communications.

Best Publications

  • Differential requirement for caspase 9 in apoptotic pathways in vivo

    Razqallah Hakem;Razqallah Hakem;Anne Hakem;Anne Hakem;Gordon S Duncan;Gordon S Duncan;Jeffrey T Henderson

  • TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

    Mark A. Lomaga;Wen Chen Yeh;Ildiko Sarosi;Gordon S. Duncan

  • Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors

    Akinori Takaoka;Hideyuki Yanai;Seiji Kondo;Gordon Duncan

  • Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes

    Minna Woo;Razqallah Hakem;Maria S. Soengas;Gordon S. Duncan

  • Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

    Nobutaka Suzuki;Shinobu Suzuki;Gordon S. Duncan;Douglas G. Millar

  • T-cell co-stimulation through B7RP-1 and ICOS

    Steven K. Yoshinaga;John S. Whoriskey;Sanjay D. Khare;Ulla Sarmiento

  • ICOS is essential for effective T-helper-cell responses.

    Anna Tafuri;Arda Shahinian;Arda Shahinian;Friedhelm Bladt;Steve K. Yoshinaga

  • Bcl10 Is a Positive Regulator of Antigen Receptor–Induced Activation of NF-κ B and Neural Tube Closure

    Jürgen Ruland;Jürgen Ruland;Gordon S Duncan;Gordon S Duncan;Andrew Elia;Andrew Elia;Ivan del Barco Barrantes;Ivan del Barco Barrantes

  • The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses

    Woong-Kyung Suh;Beata U Gajewska;Hitoshi Okada;Matthew A Gronski

  • Regulation of T Cell Receptor Signaling by Tyrosine Phosphatase SYP Association with CTLA-4

    Luc E. M. Marengère;Paul Waterhouse;Gordon S. Duncan;Hans-Willi Mittrücker

  • Genetic evidence for functional redundancy of Platelet/Endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions.

    G S Duncan;D P Andrew;H Takimoto;H Takimoto;S A Kaufman

  • Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury

    Thorsten Berger;Atsushi Togawa;Gordon S. Duncan;Andrew J. Elia

  • Glutathione Primes T Cell Metabolism for Inflammation

    Tak W. Mak;Tak W. Mak;Melanie Grusdat;Gordon S. Duncan;Catherine Dostert

  • Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.

    Atsushi Hirao;Alison Cheung;Gordon Duncan;Pierre Marie Girard

  • Differential Requirement for Malt1 in T and B Cell Antigen Receptor Signaling

    Jürgen Ruland;Jürgen Ruland;Gordon S Duncan;Andrew Wakeham;Tak W Mak

  • Abnormal Development of Intestinal Intraepithelial Lymphocytes and Peripheral Natural Killer Cells in Mice Lacking the IL-2 Receptor β Chain

    Haruhiko Suzuki;Gordon S. Duncan;Hiroaki Takimoto;Tak W. Mak

  • RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis

    Anne Hakem;Otto Sanchez-Sweatman;Annick You-Ten;Gordon Duncan

  • iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS.

    David R. McIlwain;Philipp A. Lang;Philipp A. Lang;Thorsten Maretzky;Koichi Hamada

  • Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo.

    Michael Lohoff;Michael Lohoff;David Ferrick;David Ferrick;Hans-Willi Mittrücker;Gordon S Duncan

  • Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo

    Shintaro Kamizono;Shintaro Kamizono;Gordon S. Duncan;Markus G. Seidel;Akira Morimoto

Frequent Co-Authors

Tak W. Mak
Tak W. Mak Princess Margaret Cancer Centre
Tak W. Mak
Tak W. Mak Princess Margaret Cancer Centre
Andrew Wakeham
Andrew Wakeham Princess Margaret Cancer Centre
Pamela S. Ohashi
Pamela S. Ohashi Princess Margaret Cancer Centre
Andrew E. H. Elia
Andrew E. H. Elia Harvard University
Philipp A. Lang
Philipp A. Lang Heinrich Heine University Düsseldorf
Razqallah Hakem
Razqallah Hakem University of Toronto
Josef M. Penninger
Josef M. Penninger University of British Columbia
Michael Lohoff
Michael Lohoff Philipp University of Marburg
Andrew J. Elia
Andrew J. Elia Princess Margaret Cancer Centre

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