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Immunology

D-Index
64
Citations
18831
World Ranking
2902
National Ranking
192

Overview

Viktor Umansky is affiliated with Heidelberg University in Germany and works primarily in the fields of Immunology and Microbiology, Medicine, and Biochemistry, Genetics and Molecular Biology. Their research focuses on topics such as immune cells in cancer, cancer immunotherapy and biomarkers, immunotherapy and immune responses, immune cell function and interaction, immune response and inflammation, chemokine receptors and signaling, and histone deacetylase inhibitors research.

Their frequent coauthors include Jochen Utikal, Peter Altevogt, Christopher Groth, Ihor Arkhypov, and Daniel Novak. Viktor Umansky has published multiple articles in leading scientific journals, with recurrent contributions to the Journal for ImmunoTherapy of Cancer, International Journal of Molecular Sciences, Cancers, International Journal of Cancer, and Frontiers in Immunology.

Significant recent publications include the following:

  • IL-6 as a major regulator of MDSC activity and possible target for cancer immunotherapy, 2020, Cellular Immunology
  • Myeloid-derived suppressor cells in cancer and cancer therapy, 2024, Nature Reviews Clinical Oncology
  • IL-6 regulates CCR5 expression and immunosuppressive capacity of MDSC in murine melanoma, 2020, Journal for ImmunoTherapy of Cancer
  • Eosinophil accumulation predicts response to melanoma treatment with immune checkpoint inhibitors, 2020, OncoImmunology
  • STAT3 inhibitor Napabucasin abrogates MDSC immunosuppressive capacity and prolongs survival of melanoma-bearing mice, 2022, Journal for ImmunoTherapy of Cancer

The scientist's research extensively covers myeloid-derived suppressor cells (MDSC) and their role in cancer and cancer therapy, as well as the regulatory functions of IL-6 in immune responses related to cancer progression. Their work also encompasses studies on immune checkpoint inhibitors and molecular pathways that influence immune cell behavior in the tumor microenvironment.

Viktor Umansky's contributions mostly span immunology, oncology, and molecular biology subfields, highlighting the intersection of immune mechanisms and cancer biology. The body of work includes 42 publications in immunology, 22 in oncology, and 16 in molecular biology.

Best Publications

  • Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

    Vincenzo Bronte;Sven Brandau;Shu Hsia Chen;Mario P. Colombo

  • NASH limits anti-tumour surveillance in immunotherapy-treated HCC

    Dominik Pfister;Dominik Pfister;Nicolás Gonzalo Núñez;Roser Pinyol;Olivier Govaere

  • Immunosuppression mediated by myeloid-derived suppressor cells (MDSCs) during tumour progression

    Christopher Groth;Christopher Groth;Xiaoying Hu;Xiaoying Hu;Rebekka Weber;Rebekka Weber;Viktor Fleming;Viktor Fleming

  • Myeloid-Derived Suppressor Cells Hinder the Anti-Cancer Activity of Immune Checkpoint Inhibitors.

    Rebekka Weber;Rebekka Weber;Viktor Fleming;Viktor Fleming;Xiaoying Hu;Xiaoying Hu;Vasyl Nagibin;Vasyl Nagibin

  • Tumor-Infiltrating Monocytic Myeloid-Derived Suppressor Cells Mediate CCR5-Dependent Recruitment of Regulatory T Cells Favoring Tumor Growth

    Eva Schlecker;Ana Stojanovic;Christian Eisen;Christian Quack

  • The Role of Myeloid-Derived Suppressor Cells (MDSC) in Cancer Progression

    Viktor Umansky;Carolin Blattner;Christoffer Gebhardt;Jochen Utikal

  • Targeting Myeloid-Derived Suppressor Cells to Bypass Tumor-Induced Immunosuppression.

    Viktor Fleming;Viktor Fleming;Xiaoying Hu;Xiaoying Hu;Rebekka Weber;Rebekka Weber;Vasyl Nagibin;Vasyl Nagibin

  • Bone marrow as a priming site for T-cell responses to blood-borne antigen

    Markus Feuerer;Philipp Beckhove;Natalio Garbi;Yolanda Mahnke

  • NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo

    Tadepally Lakshmikanth;Shannon Burke;Talib Hassan Ali;Silvia Kimpfler

  • Chronic inflammation promotes myeloid-derived suppressor cell activation blocking antitumor immunity in transgenic mouse melanoma model

    Meyer C;Sevko A;Ramacher M;Bazhin Av

  • Myeloid Cells and Related Chronic Inflammatory Factors as Novel Predictive Markers in Melanoma Treatment with Ipilimumab.

    Christoffer Gebhardt;Alexandra Sevko;Huanhuan Jiang;Huanhuan Jiang;Ramtin Lichtenberger

  • SOX2 in development and cancer biology.

    Daniel Novak;Laura Hüser;Jonathan J. Elton;Viktor Umansky

  • Myeloid-derived suppressor cells in cancer and cancer therapy

    Unknown

  • CTLA-4 and PD-L1 Checkpoint Blockade Enhances Oncolytic Measles Virus Therapy

    Christine E Engeland;Christine E Engeland;Christian Grossardt;Rūta Veinalde;Sascha Bossow

  • IL-6 as a major regulator of MDSC activity and possible target for cancer immunotherapy

    Rebekka Weber;Christopher Groth;Samantha Lasser;Ihor Arkhypov

  • Antitumor effect of paclitaxel is mediated by inhibition of myeloid-derived suppressor cells and chronic inflammation in the spontaneous melanoma model.

    Alexandra Sevko;Alexandra Sevko;Tillmann Michels;Tillmann Michels;Melissa Vrohlings;Melissa Vrohlings;Ludmila Umansky

  • Body fluid exosomes promote secretion of inflammatory cytokines in monocytic cells via Toll-like receptor signaling.

    Niko P. Bretz;Johannes Ridinger;Anne-Kathleen Rupp;Katharina Rimbach

  • Extracellular vesicle-mediated transfer of functional RNA in the tumor microenvironment

    Kirsten Ridder;Alexandra Sevko;Janina Heide;Maria Dams

  • Tumor-derived microRNAs induce myeloid suppressor cells and predict immunotherapy resistance in melanoma

    Veronica Huber;Viviana Vallacchi;Viktor Fleming;Xiaoying Hu

  • Deciphering myeloid-derived suppressor cells: isolation and markers in humans, mice and non-human primates

    Luca Cassetta;Espen Sønderaal Bækkevold;Sven Brandau;Anna Bujko

  • Low-dose gemcitabine depletes regulatory T cells and improves survival in the orthotopic Panc02 model of pancreatic cancer.

    Ivan Shevchenko;Svetlana Karakhanova;Sabine Soltek;Julia Link

Frequent Co-Authors

Jochen Utikal
Jochen Utikal German Cancer Research Center
Philipp Beckhove
Philipp Beckhove German Cancer Research Center
Dirk Schadendorf
Dirk Schadendorf University of Duisburg-Essen
Michael R. Shurin
Michael R. Shurin University of Pittsburgh
Volker Schirrmacher
Volker Schirrmacher German Cancer Research Center
Masashi Kato
Masashi Kato Nagoya University
Hellmut G. Augustin
Hellmut G. Augustin Heidelberg University
Jens Werner
Jens Werner Ludwig-Maximilians-Universität München
Christine S. Falk
Christine S. Falk Hannover Medical School
Peter Altevogt
Peter Altevogt German Cancer Research Center

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