World's Best Scientists 2026 revealed!
Hellmut G. Augustin

Hellmut G. Augustin

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Biology and Biochemistry
Germany
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
102
Citations
34582
World Ranking
1381
National Ranking
88

Medicine

D-Index
102
Citations
34125
World Ranking
7732
National Ranking
438

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2025 - Research.com Biology and Biochemistry in Germany Leader Award

Overview

Hellmut G. Augustin is affiliated with Heidelberg University in Germany and has a significant research presence in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work is prominently positioned at the intersection of molecular biology, oncology, and immunology, reflecting a multidisciplinary approach to complex biomedical challenges.

The scientist's research spans several focused subfields with a strong emphasis on molecular biology, oncology, immunology, cancer research, and cardiovascular medicine. Their investigations often explore fundamental biological processes and disease mechanisms.

Key topics of research addressed by Augustin include:

  • Angiogenesis and VEGF in Cancer
  • Cancer Cells and Metastasis
  • Epigenetics and DNA Methylation
  • Lipid metabolism and disorders
  • Liver Disease Diagnosis and Treatment
  • Lymphatic System and Diseases
  • Single-cell and spatial transcriptomics

Frequent publication venues for their research include:

  • Cancer Research
  • The Journal of Experimental Medicine
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • Developmental Cell

Among recent published papers by Hellmut G. Augustin are notable contributions such as:

  • "A systems view of the vascular endothelium in health and disease", 2024, Cell
  • "NASH limits anti-tumour surveillance in immunotherapy-treated HCC", 2021, Nature
  • "Visceral obesity and insulin resistance associate with CD36 deletion in lymphatic endothelial cells", 2021, Nature Communications
  • "STAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis", 2021, Science Signaling
  • "A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie-Wnt signaling axis in the liver", 2021, Developmental Cell

Their research network includes collaborations with frequent co-authors such as Mahak Singhal, Nicolas Gengenbacher, Carolin Mogler, Moritz Jakab, and Mathias Heikenwälder, reflecting ongoing cooperative efforts in related scientific areas.

Best Publications

  • Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

    Hellmut G. Augustin;Gou Young Koh;Gavin Thurston;Kari Alitalo

  • NASH limits anti-tumour surveillance in immunotherapy-treated HCC

    Dominik Pfister;Dominik Pfister;Nicolás Gonzalo Núñez;Roser Pinyol;Olivier Govaere

  • Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation.

    Ulrike Fiedler;Yvonne Reiss;Marion Scharpfenecker;Verena Grunow

  • Heterogeneity of Angiogenesis and Blood Vessel Maturation in Human Tumors: Implications for Antiangiogenic Tumor Therapies

    Anne Eberhard;Sebastian Kahlert;Valentin Goede;Bernhard Hemmerlein

  • The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies.

    Ulrike Fiedler;Marion Scharpfenecker;Stefanie Koidl;Anja Hegen

  • Angiopoietins: a link between angiogenesis and inflammation.

    Ulrike Fiedler;Hellmut G. Augustin

  • A novel vascular endothelial growth factor encoded by Orf virus, VEGF‐E, mediates angiogenesis via signalling through VEGFR‐2 (KDR) but not VEGFR‐1 (Flt‐1) receptor tyrosine kinases

    Marlene Meyer;Matthias Clauss;Albrecht Lepple-Wienhues;Johannes Waltenberger

  • Integration of endothelial cells in multicellular spheroids prevents apoptosis and induces differentiation

    Thomas Korff;Hellmut G. Augustin

  • Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology

    Hellmut G. Augustin;Hellmut G. Augustin;Gou Young Koh

  • Consensus guidelines for the use and interpretation of angiogenesis assays

    Patrycja Nowak-Sliwinska;Kari Alitalo;Elizabeth Allen;Andrey Anisimov

  • Tensional forces in fibrillar extracellular matrices control directional capillary sprouting

    Thomas Korff;Hellmut G. Augustin

  • The role of the Angiopoietins in vascular morphogenesis

    Markus Thomas;Markus Thomas;Hellmut G. Augustin;Hellmut G. Augustin

  • Blood vessel maturation in a 3-dimensional spheroidal coculture model: direct contact with smooth muscle cells regulates endothelial cell quiescence and abrogates VEGF responsiveness

    Thomas Korff;Sarah Kimmina;Georg Martiny-Baron;Hellmut G. Augustin

  • Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling

    Moritz Felcht;Robert Luck;Alexander Schering;Philipp Seidel

  • The Tie-2 ligand angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism

    Marion Scharpfenecker;Ulrike Fiedler;Yvonne Reiss;Hellmut G. Augustin

  • Differentiation of endothelial cells: analysis of the constitutive and activated endothelial cell phenotypes.

    Hellmut G. Augustin;Detlef H. Kozian;Robert C. Johnson

  • Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia

    Keizo Kanasaki;Kristin Palmsten;Hikaru Sugimoto;Shakil Ahmad

  • Analysis of blood vessel maturation processes during cyclic ovarian angiogenesis.

    Valentin Goede;Tobias Schmidt;Sarah Kimmina;Detlef Kozian

  • Induction of inflammatory angiogenesis by monocyte chemoattractant protein‐1

    Valentin Goede;Laura Brogelli;Marina Ziche;Hellmut G. Augustin

  • THE TIE2-LIGAND ANGIOPOIETIN-2 IS STORED IN AND RAPIDLY RELEASED UPON STIMULATION FROM ENDOTHELIAL CELL WEIBEL-PALADE BODIES

    Ulrike Fiedler;Marion Scharpfenecker;Stefanie Koidl;Anja Hegen

Frequent Co-Authors

Gou Young Koh
Gou Young Koh Korea Advanced Institute of Science and Technology
Sergij Goerdt
Sergij Goerdt Heidelberg University
Ralf H. Adams
Ralf H. Adams Max Planck Society
Jochen Utikal
Jochen Utikal German Cancer Research Center
Josep M. Llovet
Josep M. Llovet University of Barcelona
Mathias Heikenwalder
Mathias Heikenwalder German Cancer Research Center
Kari Alitalo
Kari Alitalo University of Helsinki
Stefanie Dimmeler
Stefanie Dimmeler Goethe University Frankfurt
Lars Zender
Lars Zender German Cancer Research Center
Markus Hecker
Markus Hecker University of Saskatchewan

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