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Biology and Biochemistry

D-Index
71
Citations
22818
World Ranking
6551
National Ranking
467

Overview

Sergij Goerdt is affiliated with Heidelberg University in Germany, contributing extensively to the fields of medicine and biochemistry, genetics, and molecular biology. Their research spans several subfields including immunology, molecular biology, epidemiology, dermatology, and oncology.

The scientist's work covers a range of main topics, such as:

  • Cutaneous lymphoproliferative disorders research
  • Liver physiology and pathology
  • Liver disease diagnosis and treatment
  • Fungal infections and studies
  • T-cell and retrovirus studies
  • Cutaneous melanoma detection and management
  • Pancreatic function and diabetes

Recent papers authored or co-authored by Sergij Goerdt include:

  • "Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling," 2020, Journal of Hepatology
  • "Angiodiversity and organotypic functions of sinusoidal endothelial cells," 2021, Angiogenesis
  • "Targeting of Scavenger Receptors Stabilin-1 and Stabilin-2 Ameliorates Atherosclerosis by a Plasma Proteome Switch Mediating Monocyte/Macrophage Suppression," 2022, Circulation
  • "Tumor Cell-Derived Angiopoietin-2 Promotes Metastasis in Melanoma," 2020, Cancer Research
  • "ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver," 2022, Hepatology

Sergij Goerdt has collaborated frequently with a group of co-authors, including:

  • Cyrill Géraud
  • Kai Schledzewski
  • Philipp-Sebastian Koch
  • Manuel Winkler
  • Carsten Sticht

Their publications have appeared in several venues, with frequent contributions to:

  • European Journal of Cancer
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancers
  • Acta Dermato Venereologica
  • Journal of Hepatology

Best Publications

  • Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

    Peter J Murray;Judith E Allen;Subhra K Biswas;Edward A Fisher

  • Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling

    Moritz Felcht;Robert Luck;Alexander Schering;Philipp Seidel

  • Lymphatic endothelium-specific hyaluronan receptor LYVE-1 is expressed by stabilin-1+, F4/80+, CD11b+ macrophages in malignant tumours and wound healing tissue in vivo and in bone marrow cultures in vitro: implications for the assessment of lymphangiogenesis.

    K. Schledzewski;M. Falkowski;G. Moldenhauer;P. Metharom

  • Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1 alpha with a Th2-associated expression pattern.

    Vitam Kodelja;Carola Müller;Oliver Politz;Nahid Hakij

  • Stabilin-1 and −2 constitute a novel family of fasciclin-like hyaluronan receptor homologues

    Oliver Politz;Oliver Politz;Alexei Gratchev;Peter A. G. McCOURT;Kai Schledzewski

  • Mφ1 and Mφ2 can be re-polarized by Th2 or Th1 cytokines, respectively, and respond to exogenous danger signals

    Alexei Gratchev;Julia Kzhyshkowska;Kirsten Köthe;Isabelle Muller-Molinet

  • Differentiation and gene expression profile of tumor-associated macrophages

    Astrid Schmieder;Julia Michel;Kathrin Schönhaar;Sergij Goerdt

  • Human chitinases and chitinase-like proteins as indicators for inflammation and cancer

    Julia Kzhyshkowska;Alexei Gratchev;Sergij Goerdt

  • Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway

    Julia Kzhyshkowska;Srinivas Mamidi;Alexei Gratchev;Elisabeth Kremmer

  • Novel Function of Alternatively Activated Macrophages: Stabilin-1-Mediated Clearance of SPARC

    Julia Kzhyshkowska;Gail Workman;Marina Cardó-Vila;Wadih Arap

  • Stabilin-1, a homeostatic scavenger receptor with multiple functions.

    Julia Kzhyshkowska;A. Gratchev;S. Goerdt

  • Interleukin-4 and dexamethasone counterregulate extracellular matrix remodelling and phagocytosis in type-2 macrophages.

    A. Gratchev;J. Kzhyshkowska;J. Utikal;S. Goerdt

  • Expression of stabilin-2, a novel fasciclin-like hyaluronan receptor protein, in murine sinusoidal endothelia, avascular tissues, and at solid/liquid interfaces

    Martin Falkowski;Kai Schledzewski;Berit Hansen;Sergij Goerdt

  • Nickel chloride and cobalt chloride, two common contact sensitizers, directly induce expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and endothelial leukocyte adhesion molecule (ELAM-1) by endothelial cells

    Matthias Goebeler;Georg Meinardus-Hager;Johannes Roth;Sergij Goerdt

  • Knockout of HIF-1α in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses

    Christian Werno;Heidi Menrad;Andreas Weigert;Nathalie Dehne

  • Phenotypical and molecular profiling of the extraneuronal cholinergic system of the skin.

    Hjalmar Kurzen;Hans Berger;Claudia Jäger;Wolfgang Hartschuh

  • Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding

    Berit Hansen;Paola Longati;Kjetil Elvevold;Geir-Ivar Nedredal

  • Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors

    Kai Schledzewski;Cyrill Géraud;Bernd Arnold;Shijun Wang

  • Differential expression of a gene signature for scavenger/lectin receptors by endothelial cells and macrophages in human lymph node sinuses, the primary sites of regional metastasis.

    J. H. Martens;J. Kzhyshkowska;M. Falkowski-Hansen;K. Schledzewski

  • Expression of Osteoarthritis Marker YKL-39 is Stimulated by Transforming Growth Factor Beta (TGF-beta) and IL-4 in Differentiating Macrophages.

    Alexei Gratchev;Christina Schmuttermaier;Srinivas Mamidi;LiMing Gooi

Frequent Co-Authors

Jochen Utikal
Jochen Utikal German Cancer Research Center
Julia Kzhyshkowska
Julia Kzhyshkowska Heidelberg University
Matthias Goebeler
Matthias Goebeler University of Würzburg
Hellmut G. Augustin
Hellmut G. Augustin Heidelberg University
Bernd Arnold
Bernd Arnold German Cancer Research Center
Dirk Schadendorf
Dirk Schadendorf University of Duisburg-Essen
Constantin E. Orfanos
Constantin E. Orfanos Freie Universität Berlin
Peter H. Krammer
Peter H. Krammer German Cancer Research Center
Michael P. Schön
Michael P. Schön University of Göttingen
Elisabeth Kremmer
Elisabeth Kremmer Max Planck Society

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