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Sirpa Jalkanen

Sirpa Jalkanen

D-Index & Metrics

Immunology

D-Index
104
Citations
31288
World Ranking
626
National Ranking
4

Medicine

D-Index
106
Citations
32449
World Ranking
6619
National Ranking
73

Research.com Recognitions

  • 2013 - Member of Academia Europaea
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Sirpa Jalkanen is affiliated with the University of Turku in Finland. Their research focuses primarily on the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology. Within these broader fields, they have contributed extensively to subfields including Immunology, Oncology, Molecular Biology, Physiology, and Genetics.

The scientist's work addresses key topics such as immune cells in cancer, the lymphatic system and diseases, cancer immunotherapy and biomarkers, single-cell and spatial transcriptomics, immune cell function and interaction, cancer hypoxia and metabolism, as well as genetic associations and epidemiology.

Sirpa Jalkanen has published papers in a variety of venues, with frequent contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • Scientific Reports
  • Angewandte Chemie International Edition
  • Cancers

Notable recent publications include:

  • "Lymphatic endothelial cells of the lymph node", 2020, Nature reviews. Immunology
  • "Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis", 2022, BMC Medicine
  • "A Single-Cell Transcriptional Roadmap of the Mouse and Human Lymph Node Lymphatic Vasculature", 2020, Frontiers in Cardiovascular Medicine
  • "Effect of Intravenous Interferon β-1a on Death and Days Free From Mechanical Ventilation Among Patients With Moderate to Severe Acute Respiratory Distress Syndrome", 2020, JAMA
  • "Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop", 2022, Cancer Cell

Frequent co-authors in their publications include:

  • Maija Hollmén
  • Marko Salmi
  • Akira Takeda
  • Juho Jalkanen
  • Veikko Salomaa

Throughout their career, Sirpa Jalkanen has been recognized by membership in prominent organizations such as the Academia Europaea since 2013 and the European Molecular Biology Organization (EMBO).

Best Publications

  • Lymphocyte recognition of high endothelium: antibodies to distinct epitopes of an 85-95-kD glycoprotein antigen differentially inhibit lymphocyte binding to lymph node, mucosal, or synovial endothelial cells.

    S Jalkanen;R F Bargatze;J de los Toyos;E C Butcher

  • Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors

    Ari V. Ahola-Olli;Peter Würtz;Aki S. Havulinna;Kristiina Aalto

  • Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectin.

    Sirpa Jalkanen;Markku Jalkanen

  • Yersinia antigens in synovial-fluid cells from patients with reactive arthritis.

    K Granfors;S Jalkanen;R von Essen;R Lahesmaa-Rantala

  • Vimentin function in lymphocyte adhesion and transcellular migration

    Mikko Nieminen;Tiina Henttinen;Tiina Henttinen;Marika Merinen;Fumiko Marttila-Ichihara

  • A lymphoid cell surface glycoprotein involved in endothelial cell recognition and lymphocyte homing in man.

    Sirpa T. Jalkanen;Sirpa T. Jalkanen;Robert F. Bargatze;Robert F. Bargatze;Lynne R. Herron;Lynne R. Herron;Eugene C. Butcher;Eugene C. Butcher

  • Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population

    Elaine T. Lim;Peter Würtz;Peter Würtz;Peter Würtz;Aki S. Havulinna;Priit Palta;Priit Palta

  • A distinct endothelial cell recognition system that controls lymphocyte traffic into inflamed synovium.

    S Jalkanen;AC Steere;RI Fox;EC Butcher

  • Cloning of Vascular Adhesion Protein 1 Reveals a Novel Multifunctional Adhesion Molecule

    David J. Smith;Marko Salmi;Petri Bono;Jukka Hellman

  • Salmonella lipopolysaccharide in synovial cells from patients with reactive arthritis.

    K. Granfors;S. Jalkanen;O. Mäki-Ikola;R. Lahesmaa-Rantala

  • A 90-kilodalton endothelial cell molecule mediating lymphocyte binding in humans

    Marko Salmi;Sirpa Jalkanen

  • Intratumoral lymphatics are essential for the metastatic spread and prognosis in squamous cell carcinomas of the head and neck region.

    Sanna-Mari Maula;Marjaana Luukkaa;Reidar Grénman;David Jackson

  • Cell-surface enzymes in control of leukocyte trafficking

    Marko Salmi;Sirpa Jalkanen

  • Macrophages, T cell receptor usage, and endothelial cell activation in the pancreas at the onset of insulin-dependent diabetes mellitus.

    A Hänninen;S Jalkanen;M Salmi;S Toikkanen

  • Biochemical properties of glycoproteins involved in lymphocyte recognition of high endothelial venules in man.

    S Jalkanen;M Jalkanen;R Bargatze;M Tammi

  • Induction and function of vascular adhesion protein-1 at sites of inflammation.

    M Salmi;K Kalimo;S Jalkanen

  • Homing of mucosal lymphocytes to the liver in the pathogenesis of hepatic complications of inflammatory bowel disease.

    Allister J Grant;Patricia F Lalor;Marko Salmi;Sirpa Jalkanen

  • Vascular Adhesion Protein-1 Mediates Adhesion and Transmigration of Lymphocytes on Human Hepatic Endothelial Cells

    Patricia F. Lalor;Sarah Edwards;Gillian McNab;Marko Salmi

  • The Biomarker GlycA Is Associated with Chronic Inflammation and Predicts Long-Term Risk of Severe Infection

    Scott C. Ritchie;Peter Würtz;Artika P. Nath;Gad Abraham

  • Circulating Form of Human Vascular Adhesion Protein-1 (VAP-1): Increased Serum Levels in Inflammatory Liver Diseases

    Riikka Kurkijärvi;David H. Adams;Rauli Leino;Timo Möttönen

  • Regulated expression of exon v6 containing isoforms of CD44 in man : downregulation during malignant transformation of tumors of squamocellular origin

    M Salmi;K Grön-Virta;P Sointu;R Grenman

  • Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population

    Elaine T. Lim;Peter Wuertz;Aki S. Havulinna;Priit Palta

Frequent Co-Authors

Marko Salmi
Marko Salmi University of Turku
Olli T. Raitakari
Olli T. Raitakari Turku University Hospital
Eugene C. Butcher
Eugene C. Butcher Stanford University
David H. Adams
David H. Adams Mount Sinai Hospital
Juhani Knuuti
Juhani Knuuti Turku University Hospital
Markus Perola
Markus Perola Finnish Institute for Health and Welfare
Kaisa Granfors
Kaisa Granfors University of Turku
Terho Lehtimäki
Terho Lehtimäki Tampere University
Johannes Kettunen
Johannes Kettunen University of Oulu
Samuli Ripatti
Samuli Ripatti University of Helsinki

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