His main research concerns Virology, Immunology, Genotype, Internal medicine and Allele. His Virology research is multidisciplinary, incorporating elements of Gene, Chemokine receptor and Severe acute respiratory syndrome coronavirus 2. The various areas that Thomas R. O'Brien examines in his Immunology study include Cell, Disease and Cohort.
Thomas R. O'Brien has researched Genotype in several fields, including Heteroduplex, Cytokine and Pathogenesis. His work in the fields of Internal medicine, such as Incidence, Confidence interval, Proportional hazards model and Hilar Cholangiocarcinomas, overlaps with other areas such as International Classification of Diseases for Oncology. His research in Allele intersects with topics in Promoter, Transcription factor and Interleukin 10.
His primary areas of study are Immunology, Virology, Internal medicine, Genotype and Hepatitis C virus. The study incorporates disciplines such as Odds ratio and Acquired immunodeficiency syndrome in addition to Immunology. His study in Virology is interdisciplinary in nature, drawing from both Antibody and Gene, Allele.
His studies deal with areas such as Gastroenterology and Hepatitis B virus as well as Internal medicine. His Hepatitis C virus study integrates concerns from other disciplines, such as Chronic infection, Viremia, Genome-wide association study and Cancer. His work deals with themes such as Epidemiology and Cohort study, which intersect with Incidence.
His scientific interests lie mostly in Hepatitis C virus, Virology, Internal medicine, Hepatocellular carcinoma and Gastroenterology. His work carried out in the field of Hepatitis C virus brings together such families of science as Cancer, Genome-wide association study, Host, Genetic association and Genotype. His studies in Genotype integrate themes in fields like Immunology and Allele.
His Immunology research is multidisciplinary, relying on both SNP and Single-nucleotide polymorphism. He combines subjects such as Homozygous genotype, Innate immune system and Pathogen with his study of Virology. While the research belongs to areas of Internal medicine, Thomas R. O'Brien spends his time largely on the problem of Hepatitis B virus, intersecting his research to questions surrounding Hepatitis C.
Thomas R. O'Brien focuses on Hepatitis B virus, Hepatitis C virus, Odds ratio, HBsAg and Immunology. His Hepatitis B virus research includes elements of Gastroenterology and Internal medicine, Hepatitis C. His Odds ratio research is multidisciplinary, incorporating perspectives in Case-control study, Physiology, Cohort and Confidence interval.
His Immunology study combines topics from a wide range of disciplines, such as Middle East respiratory syndrome, Genome-wide association study and Clinical trial. His study on Hepatitis D is covered under Virology. He is interested in Virus diseases, which is a branch of Virology.
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Contrasting Genetic Influence of CCR2 and CCR5 Variants on HIV-1 Infection and Disease Progression
Michael W. Smith;Michael Dean;Mary Carrington;Cheryl Winkler.
A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus
Ludmila Prokunina-Olsson;Brian Muchmore;Wei Tang;Ruth M Pfeiffer.
Nature Genetics (2013)
Genetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant
Cheryl Winkler;William Modi;Michael W. Smith;George W. Nelson.
New Testing Strategy to Detect Early HIV-1 Infection for Use in Incidence Estimates and for Clinical and Prevention Purposes
Robert S. Janssen;Glen A. Satten;Susan L. Stramer;Bhupat D. Rawal.
Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposure.
William A. Paxton;Scott R. Martin;Doris Tse;Thomas R. O'Brien.
Nature Medicine (1996)
Assessment of cumulative evidence on genetic associations: interim guidelines
John P A Ioannidis;Paolo Boffetta;Julian Little;Thomas R O'Brien.
International Journal of Epidemiology (2008)
GENETIC ACCELERATION OF AIDS PROGRESSION BY A PROMOTER VARIANT OF CCR5
Maureen P. Martin;Michael Dean;Michael W. Smith;Cheryl Winkler.
Reporting, Appraising, and Integrating Data on Genotype Prevalence and Gene-Disease Associations
Julian Little;Linda Bradley;Molly S Bray;Mindy Clyne.
American Journal of Epidemiology (2002)
Serum HIV-1 RNA levels and time to development of AIDS in the Multicenter Hemophilia Cohort Study
Thomas R. O'Brien;William A. Blattner;David Waters;M. Elaine Eyster.
Impact of Classification of Hilar Cholangiocarcinomas (Klatskin Tumors) on the Incidence of Intra- and Extrahepatic Cholangiocarcinoma in the United States
Tania M. Welzel;Katherine A. McGlynn;Ann W. Hsing;Thomas R. O'Brien.
Journal of the National Cancer Institute (2006)
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