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Biology and Biochemistry

D-Index
62
Citations
15573
World Ranking
10685
National Ranking
110

Overview

Bo T. Porse is affiliated with the University of Copenhagen in Denmark and has an extensive publication record spanning multiple fields within biochemistry, genetics, molecular biology, and medicine.

Their research outputs focus strongly on molecular biology and hematology, with additional work in spectroscopy, genetics, and immunology. The main scientific areas covered include acute myeloid leukemia research, advanced proteomics techniques and applications, single-cell and spatial transcriptomics, epigenetics and DNA methylation, mass spectrometry techniques and applications, cancer genomics and diagnostics, and RNA modifications in cancer.

Key recent papers authored by Bo T. Porse include:

  • Quantitative single-cell proteomics as a tool to characterize cellular hierarchies, 2021, Nature Communications
  • Basement membrane stiffness determines metastases formation, 2021, Nature Materials
  • Real-Time Search-Assisted Acquisition on a Tribrid Mass Spectrometer Improves Coverage in Multiplexed Single-Cell Proteomics, 2022, Molecular & Cellular Proteomics
  • Exploration of cell state heterogeneity using single-cell proteomics through sensitivity-tailored data-independent acquisition, 2023, Nature Communications
  • BloodSpot 3.0: a database of gene and protein expression data in normal and malignant haematopoiesis, 2023, Nucleic Acids Research

Frequent coauthors include:

  • Erwin M. Schoof
  • Benjamin Furtwängler
  • Nil Üresin
  • Mikkel Bruhn Schuster
  • Kim Theilgaard-Mönch

The publication venues in which Bo T. Porse commonly publishes their research are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Experimental Hematology
  • Molecular & Cellular Proteomics
  • Haematologica

Their work integrates advanced methodologies in proteomics and mass spectrometry to investigate cellular heterogeneity and cancer biology, particularly focusing on blood-related diseases and cellular mechanisms at the single-cell level.

Best Publications

  • Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors

    Franziska Paul;Yaâara Arkin;Amir Giladi;Diego Adhemar Jaitin

  • Bone Marrow-Derived Macrophages (BMM): Isolation and Applications

    Joachim Weischenfeldt;Bo Porse

  • The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

    Adrian P. Bracken;Daniela Kleine-Kohlbrecher;Nikolaj Dietrich;Diego Pasini

  • Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block

    Peggy Kirstetter;Kristina Anderson;Bo T Porse;Sten Eirik W Jacobsen

  • The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery

    Hendrik G. Stunnenberg;Martin Hirst

  • EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas

    Faizaan Mohammad;Simon Weissmann;Benjamin Leblanc;Deo P Pandey

  • Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes

    Diego Pasini;Martina Malatesta;Hye Ryung Jung;Julian Walfridsson

  • E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo.

    Bo T. Porse;Thomas Å. Pedersen;Xiufeng Xu;Bo Lindberg

  • BloodSpot: a database of gene expression profiles and transcriptional programs for healthy and malignant haematopoiesis.

    Frederik Otzen Bagger;Damir Sasivarevic;Sina Hadi Sohi;Linea Gøricke Laursen

  • BLUEPRINT to decode the epigenetic signature written in blood

    David Adams;Lucia Altucci;Stylionos E. Antonarakis;Juan Ballesteros

  • Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells.

    Peggy Kirstetter;Mikkel B Schuster;Oksana Bereshchenko;Susan Moore

  • NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements

    Joachim Weischenfeldt;Inge Damgaard;David Bryder;Kim Theilgaard-Mönch

  • PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2

    Sika Zheng;Erin E Gray;Geetanjali Chawla;Bo Torben Porse

  • Quantitative single-cell proteomics as a tool to characterize cellular hierarchies.

    Erwin M. Schoof;Benjamin Furtwängler;Nil Üresin;Nicolas Rapin

  • microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus.

    Eleonora Leucci;Francesca Patella;Francesca Patella;Johannes Waage;Kim Holmstrøm

  • Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis

    Kasper D. Rasmussen;Guangshuai Jia;Jens V. Johansen;Marianne T. Pedersen

  • The functional consequences of intron retention: Alternative splicing coupled to NMD as a regulator of gene expression

    Ying Ge;Bo T. Porse

  • Disease evolution and outcomes in familial AML with germline CEBPA mutations

    Kiran Tawana;Jun Wang;Aline Renneville;Aline Renneville;Csaba Bödör

  • Effect of Apolipoprotein M on High Density Lipoprotein Metabolism and Atherosclerosis in Low Density Lipoprotein Receptor Knock-out Mice

    Christina Christoffersen;Matti Jauhiainen;Markus Moser;Bo Porse

  • Erratum: Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors (Cell (2015) 163 (1663-1677))

    Franziska Paul;Ya'Ara Arkin;Amir Giladi;Diego Adhemar Jaitin

Frequent Co-Authors

Roger A. Garrett
Roger A. Garrett University of Copenhagen
Niels Borregaard
Niels Borregaard University of Copenhagen
Claus Nerlov
Claus Nerlov University of Oxford
Ole Winther
Ole Winther Technical University of Denmark
Kristian Helin
Kristian Helin Institute of Cancer Research
Lars Bullinger
Lars Bullinger Charité - University Medicine Berlin
John E. Dick
John E. Dick Princess Margaret Cancer Centre
Sten Eirik W. Jacobsen
Sten Eirik W. Jacobsen University of Oxford
Albin Sandelin
Albin Sandelin University of Copenhagen
Jude Fitzgibbon
Jude Fitzgibbon Queen Mary University of London

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