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Biology and Biochemistry
Canada
2023
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Medicine
Canada
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
112
Citations
81476
World Ranking
878
National Ranking
19

Medicine

D-Index
112
Citations
81456
World Ranking
5044
National Ranking
194

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Canada Leader Award
  • 2023 - Research.com Medicine in Canada Leader Award
  • 2022 - Research.com Biology and Biochemistry in Canada Leader Award
  • 2014 - Fellow of the Royal Society, United Kingdom
  • 2004 - Fellow of the Royal Society of Canada Academy of Science

Overview

John E. Dick is affiliated with the Princess Margaret Cancer Centre in Canada. Their research primarily focuses on medicine and biochemistry, genetics, and molecular biology, with particular expertise in hematology, molecular biology, cancer research, immunology, and genetics.

The scientist's work covers a range of key topics including acute myeloid leukemia research, hematopoietic stem cell transplantation, cancer genomics and diagnostics, single-cell and spatial transcriptomics, acute lymphoblastic leukemia research, immune cell function and interaction, and histone deacetylase inhibitors research.

Recent publications by John E. Dick include:

  • Quantitative single-cell proteomics as a tool to characterize cellular hierarchies, 2021, Nature Communications
  • A cellular hierarchy framework for understanding heterogeneity and predicting drug response in acute myeloid leukemia, 2022, Nature Medicine
  • CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells, 2020, Blood
  • Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia, 2021, Cancer Discovery
  • Mutational Landscape and Patterns of Clonal Evolution in Relapsed Pediatric Acute Lymphoblastic Leukemia, 2020, Blood Cancer Discovery

Their frequent co-authors include Andy G.X. Zeng, Mark D. Minden, Véronique Voisin, Jessica McLeod, and Olga I. Gan.

John E. Dick has published extensively in several venues, most notably Blood, bioRxiv (Cold Spring Harbor Laboratory), Experimental Hematology, Blood Cancer Discovery, and Cell Stem Cell.

Awards conferred to John E. Dick include Fellow of the Royal Society of Canada in 2004, recognized by the Academy of Science, and Fellow of the Royal Society in the United Kingdom in 2014.

Best Publications

  • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

    Dominique Bonnet;John E. Dick

  • A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

    Tsvee Lapidot;Christian Sirard;Josef Vormoor;Barbara Murdoch

  • A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

    Catherine A. O’Brien;Aaron Pollett;Steven Gallinger;John E. Dick;John E. Dick

  • Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells.

    Michael F. Clarke;John E. Dick;Peter B. Dirks;Connie J. Eaves

  • Evolution of the Cancer Stem Cell Model

    Antonija Kreso;John E. Dick

  • The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

    Jinghui Zhang;Li Ding;Linda Holmfeldt;Gang Wu

  • Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

    Liran I. Shlush;Sasan Zandi;Amanda Mitchell;Weihsu Claire Chen

  • Targeting of CD44 eradicates human acute myeloid leukemic stem cells

    Liqing Jin;Kristin J Hope;Qiongli Zhai;Florence Smadja-Joffe

  • Stem cell concepts renew cancer research.

    John E. Dick

  • Mass cytometry: technique for real time single cell multitarget immunoassay based on inductively coupled plasma time-of-flight mass spectrometry.

    Dmitry R. Bandura;Vladimir I. Baranov;Olga I. Ornatsky;Alexei Antonov

  • Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity.

    Kristin J Hope;Liqing Jin;John E Dick

  • Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice

    Mickie Bhatia;Jean C. Y. Wang;Ursula Kapp;Dominique Bonnet

  • Stem cell gene expression programs influence clinical outcome in human leukemia

    Kolja Eppert;Katsuto Takenaka;Eric R Lechman;Levi Waldron

  • Hematopoiesis: A Human Perspective

    Sergei Doulatov;Faiyaz Notta;Faiyaz Notta;Elisa Laurenti;Elisa Laurenti;John E. Dick;John E. Dick

  • Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment.

    Faiyaz Notta;Sergei Doulatov;Sergei Doulatov;Elisa Laurenti;Elisa Laurenti;Armando Poeppl

  • Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy

    André Larochelle;Josef Vormoor;Josef Vormoor;Helmut Hanenberg;Jean C.Y. Wang

  • A newly discovered class of human hematopoietic cells with SCID-repopulating activity

    Mickie Bhatia;Dominique Bonnet;Dominique Bonnet;Barbara Murdoch;Olga I. Gan

  • Cancer stem cells: lessons from leukemia

    Jean C.Y. Wang;John E. Dick

  • Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer

    Antonija Kreso;Antonija Kreso;Catherine A. O'Brien;Catherine A. O'Brien;Peter van Galen;Olga I. Gan

  • Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/Wv mice

    John E. Dick;Maria Cristina Magli;Dennis Huszar;Robert A. Phillips

Frequent Co-Authors

Mark D. Minden
Mark D. Minden Princess Margaret Cancer Centre
James A. Kennedy
James A. Kennedy Princess Margaret Cancer Centre
Mathieu Lupien
Mathieu Lupien Princess Margaret Cancer Centre
Gary D. Bader
Gary D. Bader University of Toronto
Charles G. Mullighan
Charles G. Mullighan St. Jude Children's Research Hospital
Tsvee Lapidot
Tsvee Lapidot Weizmann Institute of Science
Aaron D. Schimmer
Aaron D. Schimmer Princess Margaret Cancer Centre
John Douglas Mcpherson
John Douglas Mcpherson University of California, Davis
Cynthia J. Guidos
Cynthia J. Guidos University of Toronto
Lincoln Stein
Lincoln Stein Ontario Institute for Cancer Research

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