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Biology and Biochemistry

D-Index
88
Citations
40909
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2642
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Overview

Tsvee Lapidot is affiliated with the Weizmann Institute of Science in Israel. Their research spans primarily within the fields of Medicine and Immunology and Microbiology, with significant contributions particularly in Immunology and Hematology. They have engaged in numerous studies that explore aspects of the immune system, hematopoietic stem cell transplantation, and related biological processes.

The main research topics of Tsvee Lapidot include:

  • Immune Response and Inflammation
  • Hematopoietic Stem Cell Transplantation
  • Immune cells in cancer
  • Neonatal Respiratory Health Research
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Mesenchymal stem cell research
  • Immune responses and vaccinations

Tsvee Lapidot has published in various peer-reviewed journals, with frequent appearances in notable venues such as:

  • Blood
  • Immunity
  • Leukemia
  • Blood Science
  • Cell

Recent papers by Tsvee Lapidot cover a range of topics in the immune and hematopoietic systems. These include:

  • Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs (2022, Cell)
  • Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling (2020, Nature Communications)
  • Bone marrow regeneration requires mitochondrial transfer from donor Cx43-expressing hematopoietic progenitors to stroma (2020, Blood)
  • Bacterial infection disrupts established germinal center reactions through monocyte recruitment and impaired metabolic adaptation (2022, Immunity)
  • Classical monocyte ontogeny dictates their functions and fates as tissue macrophages (2024, Immunity)

Collaboration is a notable aspect of Tsvee Lapidot's research career. Frequent coauthors include:

  • Montaser Haddad
  • Órit Kollet
  • Eman Khatib-Massalha
  • Ekaterina Petrovich-Kopitman
  • Steffen Jung

The subfields closely connected with their work are Immunology, Hematology, Pulmonary and Respiratory Medicine, Molecular Biology, and Surgery, indicating a multidisciplinary approach to understanding disease mechanisms and therapeutic strategies within medical science.

Best Publications

  • A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

    Tsvee Lapidot;Christian Sirard;Josef Vormoor;Barbara Murdoch

  • Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4

    Amnon Peled;Isabelle Petit;Orit Kollet;Michal Magid

  • G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4

    Isabelle Petit;Martine Szyper-Kravitz;Arnon Nagler;Meir Lahav

  • Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally

    Eugene E Varfolomeev;Marcus Schuchmann;Victor Luria;Nuchanard Chiannilkulchai

  • How do stem cells find their way home

    Tsvee Lapidot;Ayelet Dar;Orit Kollet

  • Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells.

    Tsvee Lapidot;Isabelle Petit

  • The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34(+) cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice.

    Amnon Peled;Orit Kollet;Tanya Ponomaryov;Isabelle Petit

  • Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy

    André Larochelle;Josef Vormoor;Josef Vormoor;Helmut Hanenberg;Jean C.Y. Wang

  • Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells

    Orit Kollet;Ayelet Dar;Shoham Shivtiel;Alexander Kalinkovich

  • HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver.

    Orit Kollet;Shoham Shivtiel;Yuan Qing Chen;Jenny Suriawinata

  • Cancer stem cell definitions and terminology: the devil is in the details

    Peter Valent;Dominique Bonnet;Ruggero De Maria;Tsvee Lapidot

  • Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function

    Tanya Ponomaryov;Amnon Peled;Isabelle Petit;Russell S. Taichman

  • The chemokine SDF-1 stimulates integrin-mediated arrest of CD34+ cells on vascular endothelium under shear flow

    Amnon Peled;Valentin Grabovsky;Liliana Habler;Judith Sandbank

  • Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in SCID mice

    Tsvee Lapidot;Francoise Pflumio;Monica Doedens;Barbara Murdoch

  • The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID and NOD/SCID/B2m(null) mice.

    T Lapidot;O Kollet

  • Distinct bone marrow blood vessels differentially regulate haematopoiesis

    Tomer Itkin;Shiri Gur-Cohen;Joel A. Spencer;Amir Schajnovitz

  • CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow.

    Abraham Avigdor;Polina Goichberg;Shoham Shivtiel;Ayelet Dar

  • CXCR4 regulates migration and development of human acute myelogenous leukemia stem cells in transplanted NOD/SCID mice.

    Sigal Tavor;Isabelle Petit;Svetlana Porozov;Abraham Avigdor;Abraham Avigdor

  • Stromal-derived factor-1 promotes the growth, survival, and development of human bone marrow stromal stem cells

    Angela Kortesidis;Andrew Zannettino;Sandra Isenmann;Songtao Shi

  • Subsecond Induction of α4 Integrin Clustering by Immobilized Chemokines Stimulates Leukocyte Tethering and Rolling on Endothelial Vascular Cell Adhesion Molecule 1 under Flow Conditions

    Valentin Grabovsky;Sara Feigelson;Chun Chen;Diederik A. Bleijs

Frequent Co-Authors

Orit Kollet
Orit Kollet Weizmann Institute of Science
Arnon Nagler
Arnon Nagler Sheba Medical Center
John E. Dick
John E. Dick Princess Margaret Cancer Centre
Michel Revel
Michel Revel Weizmann Institute of Science
Amnon Peled
Amnon Peled Hebrew University of Jerusalem
Ronen Alon
Ronen Alon Weizmann Institute of Science
Wolfram Ruf
Wolfram Ruf Johannes Gutenberg University of Mainz
Yair Reisner
Yair Reisner The University of Texas MD Anderson Cancer Center
Ralf H. Adams
Ralf H. Adams Max Planck Society
Charles T. Esmon
Charles T. Esmon Oklahoma Medical Research Foundation

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