His primary scientific interests are in Tissue factor, Cell biology, Signal transduction, Thrombin and Biochemistry. His Tissue factor study combines topics in areas such as Serine protease, Cancer research, Angiogenesis, Thromboplastin and Immunology. Wolfram Ruf has included themes like Cancer cell and Metastasis in his Cancer research study.
Vascular remodelling in the embryo, Small intestine and Gut flora is closely connected to Cell surface receptor in his research, which is encompassed under the umbrella topic of Cell biology. The various areas that he examines in his Signal transduction study include Endocrinology, Protease-Activated Receptor 1, Molecular biology, Internal medicine and Growth factor. Many of his studies on Thrombin involve topics that are commonly interrelated, such as Cell signaling.
Wolfram Ruf focuses on Tissue factor, Cell biology, Cancer research, Signal transduction and Biochemistry. Wolfram Ruf has researched Tissue factor in several fields, including Immunology, Molecular biology, Thrombin and Thromboplastin. His Cell biology study combines topics from a wide range of disciplines, such as Receptor, Integrin and Endothelial protein C receptor.
His Cancer research research is multidisciplinary, incorporating elements of Cancer cell, Cancer and Metastasis. His work deals with themes such as Endocrinology, Internal medicine, Cytokine, Phosphorylation and Protease-activated receptor, which intersect with Signal transduction. His study in Biochemistry is interdisciplinary in nature, drawing from both Factor VII and Factor X.
Wolfram Ruf mainly investigates Tissue factor, Cell biology, Cancer research, Signal transduction and Internal medicine. His Tissue factor research integrates issues from Inflammation, Cell signaling, Protease-activated receptor and Thromboplastin. Wolfram Ruf combines subjects such as Endothelial protein C receptor, Integrin and Transcription factor with his study of Cell biology.
His Cancer research research incorporates themes from Cell and Metastasis. His studies deal with areas such as Endocrinology and Cardiology as well as Internal medicine. The concepts of his Coagulation study are interwoven with issues in Hemostasis, Thrombosis and Thrombin.
His primary areas of investigation include Tissue factor, Cancer research, Cell biology, Thromboplastin and Coagulation. The Tissue factor study combines topics in areas such as Inflammation, PTEN and Proteases. His research investigates the connection with Proteases and areas like Protease-activated receptor which intersect with concerns in Innate immune system.
The Cancer research study which covers Signal transduction that intersects with Immunotherapy, Cytotoxic T cell and Tissue factor pathway inhibitor. His studies in Cell biology integrate themes in fields like Endothelial protein C receptor and Integrin. His research on Coagulation also deals with topics like
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Activation of Endothelial Cell Protease Activated Receptor 1 by the Protein C Pathway
Matthias Riewald;Ramona J. Petrovan;Aaron Donner;Barbara M. Mueller.
The structural biology of expression and function of tissue factor.
Thomas S Edgington;Nigel Mackman;Korbinian Brand;Wolfram Ruf.
Thrombosis and Haemostasis (1991)
Lethal E. coli septic shock is prevented by blocking tissue factor with monoclonal antibody.
F. B. Taylor;A. Chang;W. Ruf;J. H. Morrissey.
Circulatory shock (1991)
Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasis.
Barbara M. Mueller;Ralph A. Reisfeld;Thomas S. Edgington;Wolfram Ruf.
Proceedings of the National Academy of Sciences of the United States of America (1992)
A ROLE FOR TISSUE FACTOR IN CELL ADHESION AND MIGRATION MEDIATED BY INTERACTION WITH ACTIN-BINDING PROTEIN 280
Ilka Ott;Edgar G. Fischer;Yohei Miyagi;Barbara M. Mueller.
Journal of Cell Biology (1998)
Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor
Matthias Riewald;Wolfram Ruf.
Proceedings of the National Academy of Sciences of the United States of America (2001)
Regulation of angiogenesis by tissue factor cytoplasmic domain signaling
Mattias Belting;Michael I Dorrell;Staffan Sandgren;Edith Aguilar.
Nature Medicine (2004)
Disulfide isomerization switches tissue factor from coagulation to cell signaling.
Jasimuddin Ahamed;Henri H. Versteeg;Marjolein Kerver;Vivien M. Chen.
Proceedings of the National Academy of Sciences of the United States of America (2006)
Inhibition of tissue factor signaling suppresses tumor growth
Henri H. Versteeg;Florence Schaffner;Marjolein Kerver;Helle H. Petersen.
STRUCTURAL BIOLOGY OF TISSUE, FACTOR, THE INITIATOR OF THROMBOGENESIS IN VIVO
Wolfram Ruf;Thomas S. Edgington.
The FASEB Journal (1994)
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